The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host(1-5). Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonel...
Yuko Naito-Matsui Leela R. L. Davies Hiromu Takematsu Hsun-Hua Chou Pam Tangvoranuntakul Aaron F. Carlin Andrea Verhagen Charles J. Heyser Seung-Wan Yoo Biswa Choudhury James C. Paton Adrienne W. Paton Nissi M. Varki Ronald L. Schnaar Ajit Varki
JOURNAL OF BIOLOGICAL CHEMISTRY 292(7) 2557-2570 2017年2月 [査読有り]
All vertebrate cell surfaces display a dense glycan layer often terminated with sialic acids, which have multiple functions due to their location and diverse modifications. The major sialic acids in most mammalian tissues are N-acetylneuraminic ac...
Shoib Siddiqui Flavio Schwarz Stevan Springer Zahra Khedri Hai Yu Lingquan Deng Andrea Verhagen Yuko Naito-Matsui Weiping Jiang Daniel Kim Jie Zhou Beibei Ding Xi Chen Nissi Varki Ajit Varki
JOURNAL OF BIOLOGICAL CHEMISTRY 292(3) 1029-+ 2017年1月 [査読有り]
CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has been extensively studied,...
MOLECULAR BIOLOGY OF THE CELL 27(13) 2037-2050 2016年7月 [査読有り]
Endomitosis is a special type of mitosis in which only cytokinesis-the final step of the cell division cycle-is defective, resulting in polyploid cells. Although endomitosis is biologically important, its regulatory aspects remain elusive. Psychos...
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