Lingquan Deng   Jeongmin Song   Xiang Gao   Jiawei Wang   Hai Yu   Xi Chen   Nissi Varki   Yuko Naito-Matsui   Jorge E. Galan   Ajit Varki   
CELL 159(6) 1290-1299 2014年12月 [査読有り]
Salmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid fever symptoms in experimental animals. Toxicity depends on toxin binding to terminally ...
Stefan Hutzler   Lamia Oezgoer   Yuko Naito-Matsui   Kathrin Klaesener   Thomas H. Winkler   Michael Reth   Lars Nitschke   
JOURNAL OF IMMUNOLOGY 192(11) 5406-5414 2014年6月 [査読有り]
Siglec-G is an inhibitory receptor on B1 cells. Siglec-G-deficient mice show a large B1 cell expansion, owing to higher BCR-induced Ca2+ signaling and enhanced cellular survival. It was unknown why Siglec-G shows a B1 cell-restricted inhibitory fu...
JOURNAL OF BIOLOGICAL CHEMISTRY 289(3) 1564-1579 2014年1月 [査読有り]
Background: Sialic acids play key roles in molecular recognition. Results: T-cell activation alters the principal sialic acid species profile, regulating expression of siglec ligands, T-cell activation per se, and T cell-B cell interactions. Concl...
Tadafumi S. Tochikura   Yuko Naito   Yasunori Kozutsumi   Tsutomu Hohdatsu   
RESEARCH IN VETERINARY SCIENCE 92(2) 327-332 2012年4月 [査読有り]
The infection of the feline T-lymphocyte cell line FeT-J with the feline immunodeficiency virus (FIV) Petaluma strain led to the establishment of nonvirus-producing cells. One clone (C15) obtained by limiting dilution was found to express FIV in r...
JOURNAL OF BIOLOGICAL CHEMISTRY 286(31) 27214-27224 2011年8月 [査読有り]
Cellular biosynthesis of macromolecules often involves highly branched enzyme pathways, thus cellular regulation of such pathways could be rather difficult. To understand the regulatory mechanism, a systematic approach could be useful. We genetica...