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Researcher Database
Name: Shosuke Ito
Keyword: Melanin Neuromelanin Melanoma HPLC
E-Mail address: sito@fujita-hu.ac.jp

Research Information (#1)
Research section-1: Analytical Chemistry
Research Information (#2)
Research section-2: Dermatology
Research Information (#3)
Research section-3: Neurochemistry

Organization / Department (#1)
Organization-1: Fujita Health University
Department(1) 1: Faculty of Medical Technology
Position-1: Professor
Address-1: 1-98,Toyoake aichi JAPAN
Tel-1: 0562-93-2595
FAX-1: 0562-93-4595

Academic Meeting / Research Meeting (#1)
Academic Meeting-1: Japanese Chemical Society
Academic Meeting / Research Meeting (#2)
Academic Meeting-2: Japanese Cancer Association
Academic Meeting / Research Meeting (#3)
Academic Meeting-3: Society for Pigment Cell Research
Position Workgroups-3: Council Member
Academic Meeting / Research Meeting (#4)
Academic Meeting-4: European Society for Pigment Cell Research
Position Workgroups-4: Honorary Member
Academic Meeting / Research Meeting (#5)
Academic Meeting-5: PanAmerican Society for Pigment Cell Research
Academic Meeting / Research Meeting (#6)
Academic Meeting-6: Society for Investigative Dermatology

Research History [2004] (#11)
Papers-11: Naysmith L, Waterston K, Ha T, Flanagan N, Bisset Y, Ray A., Wakamatsu K, Ito S, Rees JL. Quantitative measures of the effect of the melanocortin 1 receptor (MC1R) on human pigmentary status. J Invest Dermatol 122: 423-428, 2004.

Yukitake J, Otake H, Inoue S, Wakamatsu K, Ito S. Comparison of in vivo anti-melanoma effect of enantiometic alpha-methyl- and alpha-ethyl-4-S-cysteiaminylphenol. Melanoma Res 14: 115-120, 2004.

McGraw KJ, Ito S, Wakamatsu K, Nolan PM, Jouventin P, Dobson FS, Austic RE, Safran RJ, Stiefferman LM, Hill GE, Parker RS. "You cannot always judge a plumage pigment by its color": carotenoid and melanin content of yellow- and brown-colored feathers in swallows, bluebirds, penguins, and domestic chicks. The Condor 106: 390-395, 2004.

Liu Y, Hong L, Kemp VR, Wakamatsu K, Ito S, Simon JD. Ion-exchange and adsorption of Fe(III) by sepia melanin. Pigment Cell Res 17: 262-269, 2004.

Hayashi H, Sone M, Ito S, Wakamatsu K, Kato M, Nakashima I, Nakashima T. A novel RFP-RET transgenic model with abundant eumelanin in the cochlea. Hearing Res 195: 35-40, 2004.

Rad HH, Yamashita T, Jin HY, Hirosaki K, Wakamatsu K, Ito S, Jimbow K. Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells. Exp Cell Res 298: 317-328, 2004.

Hirobe T, Takeuchi S, Hotta E, Wakamatsu K, Ito S. Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis. Pigment Cell Res 17: 506-514, 2004.

Nakatsura T, Kageshita T, Ito S, Wakamatsu K, Monji M, Ikuta Y, Senju S, Ono T, Nishimura Y. Identification of glypican-3 as a novel tumor marker for melanoma. Clin Cancer Res 10: 6612-6621, 2004.

Takeuchi S, Zhang W, Wakamatsu K, Ito S, Hearing VJ, Kraemer KH, Brash DE. Melanin acts as a potent UVB photosensitizer to cause a novel mode of cell death in murine skin. Proc Natl Acad Sci USA 101: 15076-15081, 2004.

Zucca FA, Giaveri G, Gallorini M, Alberini A, Toscani M, Locius R, Wilms H, Sulzer D, Ito S, Wakamatsu K, Zecca L. The neuromelanin of human substantia nigra: physiological and pathogenic aspects. Pigment Cell Res 17: 610-617, 2004.

Simon JD, Ito S. The chemical structure of melanin. Reply. Pigment Cell Res 17: 423-424, 2004.
Research History [2005] (#12)
Papers-12: Liu Y, Hong L, Wakamatsu K, Ito S, Adhyaru B, Bowers CR, Simon JD. Comparison of structural and chemical properties of black and red human hair melanosomes. Photochem Photobiol 81: 135-144, 2005.

Machida Y, Chiba T, Takayanagi A, Tanaka Y, Chiba T, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Takana K, Mizuno Y, Hattori N. Common anti-apoptotic roles of parkin and alpha-synclein in human dopaminergic cells. Biochem Biophys Res Commun 332: 233-240, 2005.

Adachi K, Wakamatsu K, Ito S, Miyamoto N, Nishioka T, Hirata T. An oxygen transporter hemocyanin acts on the late pathway of melanin synthesis. Pigment Cell Res 18: 214-219, 2005.

Hennessy A, Oh C, Diffey B, Wakamatsu K, Ito S, Rees J. Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation. Pigment Cell Res 18: 220-223, 2005.

Liu Y, Hong L, Wakamatsu K, Ito S, Adhyaru BB, Bowers CR, Simon JD. Comparisons of the structural and chemical properties of melanosomes isolated from RPE, iris and choroids of newborn and mature bovine eyes. Photochem Photobiol 81: 510-516, 2005.

Chintala S, Li W, Lamoreux ML, Ito S, Wakamatsu K, Sviderskoya EV, Bennett DC, Park Y-M, Gahl WA, Huizing M, Spritz RA, Ben S, Novak EK, Tan J, Swank RT. Slc7a11 controls the production of pheomelanin pigment and the proliferation of cultured cells. Proc Natl Acad Sci USA 102: 10964-10969, 2005.

Costin G-E, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Viera WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJ. Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis but do not affect intracellular trafficking of the mutant protein. Biochem J 391: 249-259, 2005.

Yang Y, Gehrke S., Haque ME, Imai Y, Kosek J, Yang L, Beal MF, Nishimura I, Wakamatsu K, Ito S, Takahashi R, Lu B. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and P13K/Akt signaling. Proc Natl Acad Sci USA 102: 13670-13675, 2005.

Adachi K, K. Kato, Wakamatsu K, Ito S, Ishimura K, Hirata T, Murata O, Kumai H. The colorimetric evaluation, histological analysis and chemical quantification of melanin content in "suntanned" fish. Pigment Cell Res 18: 465-468, 2005

Ikuta Y, Nakatsura T, Kageshita T, Fukushima S, Ito S, Wakamatsu K, Baba H, Nishimura Y. Highly sensitive diagnosis of melanoma at an early stage by detecting the serum SPARC and glypican-3 levels. Clin Cancer Res 11: 8079-8088, 2005.

Award-12: The Henry Stanley Raper Medal (International Federation of Pigment Cell Societies Scientific Award)
Research History [2006] (#13)
Papers-13: Beppu H, Shimpo K, Chihara T, Tamai I, Nomoto-Yamaji S, Ozaki S, Ito S, Kuzuya H. Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets. Phytomedicine 13:49-60 2006.

Wakamatsu K, Kavanagh R, kadekaro AL, Terzieva S, Sturm R, Leachman S, Abdel-Malek A, Ito S. Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin. Pigment Cell Res 19: 154-162, 2006.

Wakamatsu K, Takasaki A, KagedalB, Kageshita T, Ito S. Determination of eumelanin in human urine. Pigment Cell Res 19: 163-169, 2006.

Hirobe T, Wakamatsu K, Ito S, Kawa Y, Soma Y, Mizoguchi M. The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes. Europ J Cell Biol 85: 537-549, 2006.

Hauser J, Kadekaro AN, Kavanagh RJ, Wakamatsu K, Terzieva S, Schwemberger S, Babcock G, Ito S, Abdel-Malek AZ. Melanin content and the MC1R genotype independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment Cell Res 19: 303-314, 2006.

Gautam R, Novak EK, Tan J, Wakamatsu K, Ito S, Swank RT. Interaction of Hermansky-Pudlak syndrome genes in the regulation of lysosome-related organelles. Traffic 7: 779-792, 2006.

D!#%ap!#%Orazio JA, Nobuhisa T, Cui R, Arya M, Nishimura E, Spry M, Wakamatsu K, Granter S, Ito S, Fisher DE. Critical role for MC1R in UV tanning: molecular mimicking and skin protection. Nature, 443: 340-344, 2006.

Wakamatsu K, Ito S. Evaluation of melanin-related metabolites as markers of solar ultraviolet radiation. Pigment Cell Res 19: 460-464, 2006.

Kadekaro AL, Wakamatsu K, Ito S, Abdel-Malek ZA. Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair. Frontiers in Bioscience 11: 2157-2173. 2006.

Ito S. Encapsulation of a reactive core in neuromelanin. Proc Natl Acad Sci (USA) 103: 14647-14648, 2006.

Books-13: Ito S and Wakamatsu K. Chemistry of Melanins. In: Nordlund JJ, Boissy RE, Hearing VJ, King RA, Oetting WS, Ortonne JP. The Pigmentary System. Sec Ed. Blackwell Publishing, pp. 282-310, 2006.

Fri Jan 19 23:35:10 JST 2007

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