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Researcher Database
Name： Yoshiki Akatsuka, MD, PhD
Keyword： allogeneic hematopoietic cell transplanatation
GVHD
GVL
immunology
adoptive immunotherapy
vaccination with peptides
tumor antigen / immunology
E-Mail address： yakatsuk @ fujita-hu.ac.jp

Research Information (#1)
Research section-1： Identification of Novel Minor Histocompatibility Antigens relevant of Clinics
Research Information (#4)
Research section-4： Adoptive immunotherapy using CAR-T cells.

Organization / Department (#1)
Organization-1： Fujita Health University
Department(1) 1： School of Medicine
Position-1： Visiting Professor
Address-1： 1-98,Toyoake aichi JAPAN
Tel-1： 0562-93-9032
FAX-1： 0562-95-0016
Organization / Department (#2)
Organization-2： Aichi Cancer Center
Department(1) 2： Division of Immunology
Position-2： Visiting Scientist
Address-2： 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi
Tel-2： 052-762-6111　（X7045）
FAX-2： 052-764-2991

Academic Meeting / Research Meeting (#1)
Academic Meeting-1： The Japanese Society of Internal Medicine
Academic Meeting / Research Meeting (#2)
Academic Meeting-2： THE JAPANESE SOCIETY OF HEMATOLOGY
Academic Meeting / Research Meeting (#3)
Academic Meeting-3： Japanese Cancer Association
Academic Meeting / Research Meeting (#4)
Academic Meeting-4： The Japan Society for Hematopoietic Cell Transplantation
Academic Meeting / Research Meeting (#5)
Academic Meeting-5： Japanese Aｓsociation of Cancer Immunology
Academic Meeting / Research Meeting (#6)
Academic Meeting-6： American Society of Hematology
Academic Meeting / Research Meeting (#7)
Academic Meeting-7： The Japan Society of Transfusion and Cell Therapy
Academic Meeting / Research Meeting (#8)
Academic Meeting-8： Asia Pacific Blood ana Marrow Transplantation (APBMT) Group
Position Workgroups-8： ・Scientific committee (2016.11-)
・Editor-in-Chief (2016.11-)
Academic Meeting / Research Meeting (#9)
Academic Meeting-9： Society of Immunotherapy for Hematological Disorders (SIHDS)

Research History [Other] (#1)
Papers-1： 1) Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats. Matuo Y, Nishi N, Tanaka Y, Muguruma Y, Tanaka K, Akatsuka Y, Matsui SI, Sandberg AA, Wada F. Biochem Biophys Res Commun. 118(2): 467-473, 1984.

2) Detection of Philadelphia chromosome-positive acute lymphoblastic leukemia by polymerase chain reaction: possible eradication of minimal residual disease by marrow transplantation.Miyamura K, Tanimoto M, Morishima Y, Horibe K, Yamamoto K, Akatsuka Y, Kodera Y, Kojima S, Matsuyama K, Hirabayashi N, Yazaki M, Imai K, Onozawa Y, Kanamaru A, Mizutani S, Saito H. Blood. 79(5): 1366-1370, 1992.

3) Acute renal failure and degenerative tubular lesions associated with in situ formation of adenovirus immune complexes in a patient with allogeneic bone marrow transplantation. Yuzawa Y, Aoi N, Fukatsu A, Ichida S, Yoshida F, Akatsuka Y, Minami S, Kodera Y, Matsuo S. Transplantation. 55(1): 67-72, 1993.

4) Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia. Kubo K, Naoe T, Kiyoi H, Fukutani H, Kato Y, Oguri T, Yamamori S, Akatsuka Y, Kodera Y, Ohno R.Jpn J Cancer Res. 84(4): 379-387, 1993.

5) Retrovirus-mediated transfer of a hygromycin phosphotransferase-thymidine kinase fusion gene into human CD34+ bone　marrow cells. Akatsuka Y, Emi N, Kato H, Abe A, Tanimoto M, Lupton SD, Saito H. Int J Hematol. 60(4): 251-261, 1994.

6) Bone marrow transplantation for chronic myelogenous leukemia in blastic phase using a phenotypically identical unrelated volunteer donor. Akatsuka Y, Kodera Y, Yamamoto K, Minami S, Miyamura K, Morishita Y, Morishima Y, Saitoh H, Horibe K, Yamauchi T. Int J Hematol. 55(3): 249-253, 1992.
Research History [1996] (#3)
Papers-3： 1) T cell receptor clonal diversity following allogeneic marrow grafting. Akatsuka Y, Cerveny C, Hansen JA. Hum Immunol. 48(1-2): 125-134, 1996.
Research History [1997] (#4)
Papers-4： 1) Prolonged selective neutropenia after allogeneic bone marrow transplantation: possible effect of presensitization by donor lymphocytes prior to transplant.Towatari M, Miyamura K, Akatsuka Y, Yamamoto K, Minami S, Kodera Y. Int J Hematol. 66(4): 513-516, 1997.
Research History [1998] (#5)
Papers-5： 1) Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection. Martin PJ, Akatsuka Y, Hahne M, Sale G. Blood. 92(6): 2177-2181, 1998.
Research History [1999] (#6)
Papers-6： 1) Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition. Akatsuka Y, Martin EG, Madonik A, Barsoukov AA, Hansen JA. Tissue Antigens. 53(2): 122-134, 1999.

2) Immune response of post-transplant peripheral lymphocytes against the patient pre-B cell line, NAGL-1. Kasai M, Akatsuka Y, Emi N, Taji H, Kohno A, Abe A, Tanimoto M, Kodera Y, Saito H..Int J Hematol 69(2): 112-118, 1999.

3) Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells. Zhu L, Yu X, Akatsuka Y, Cooper JA, Anasetti C. Immunology. 97(1): 26-35, 1999.

4) A novel minor histocompatibility antigen recognized by HLA-A31 restricted cytotoxic T lymphocytes generated from HLA-identical bone marrow donor lymphocytes. Yazaki M, Takahashi T, Andho M, Akatsuka Y, Ito T, Miyake Y, Ito Y, Nakamura S, Wada Y. Bone Marrow Transplant. 24(2): 129-137, 1999.
Research History [2000] (#7)
Papers-7： 1) Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation. Lin MT, Tseng LH, Frangoul H, Gooley T, Pei J, Barsoukov A, Akatsuka Y, Hansen JA.. Blood. 95(12): 3832-3839, 2000.
Research History [2001] (#8)
Papers-8： 1. Brickner AG*, Warren EH*, Caldwell JA*, Akatsuka Y* (* contributed equally), Golovina TN, Zarling AL, Shabanowitz J, Eisenlohr LC, Hunt DF, Engelhard VH, Riddell SR. The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. J Exp Med 193:195-206, 2001.

2. Akatsuka Y, Warren EH, Brickner AG, Engelhard VH, Riddell SR. Determination of Intronic Sequences Adjacent to an Exon Using Polymerase Chain Reaction and Genomic DNA Library Constructed by TA Cloning. Anal Biochem 289:289-292, 2001.

3. Pei J, Akatsuka Y, Anasetti C, Lin MT, Petersdorf EW, Hansen JA, Martin PJ. Generation of HLA-C-specific cytotoxic T cells in association with marrow graft rejection: analysis of alloimmunity by T-cell　cloning and testing of T-cell-receptor rearrangements. Biol Blood Marrow Transplant 7:378-83, 2001.
Research History [2002] (#9)
Papers-9： 1. Kondo E, Topp MS, Kiem HP, Obata Y, Morishima Y, Kuzushima K, Tanimoto M, Harada M, Takahashi T, Akatsuka Y. Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells. J Immunol 169:2164-2171, 2002. (PubMed )

2. Mutimer HP, Akatsuka Y, Manley T, Chuang EL, Boeckh M, Harrington R, Jones T, Riddell SR. Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response. J Infect Dis 186:701-705, 2002. (PubMed )

3. Kuzushima K, Hayashi N, Kudoh A, Akatsuka Y, Tsujimura K, Morishima Y, Tsurumi T. Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells. Blood 101:1460-1468, 2002.

4. Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA. Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines. Tissue Antigens 59:502-511, 2002. (PubMed )

5. Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest. Transplantation 74:1773-1780, 2002. (PubMed )
Research History [2003] (#10)
Papers-10： 1. Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens. J Exp Med. 2003;197:1489-1500. (PubMed )

2. Miyazaki M, Akatsuka Y, Nishida T, Fujii N, Hiraki A, Ikeda K, Tsujimura K, Kuzushima K, Morishima Y, Sato S, Ueda R, Takahashi T. Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells. Clin Immunol. 2003;107:198-201. (PubMed )

3. Topp MS, Riddell SR, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD. Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production. J Exp Med. 2003;198:947-955. PubMed )

4. Tsujimura K, Obata Y, Kondo E, Nishida K, Matsudaira Y, Akatsuka Y, Kuzushima K, Takahashi T. Thymus leukemia antigen (TL)-specific cytotoxic T lymphocytes recognize the α1/α2 domain of TL free from antigenic peptides. Int Immunol. 2003; 15:1319-1326.

5. Akatsuka Y, Warren EH, Gooley TA, Brickner AG, Lin MT, Hansen JA, Martin PJ, Madtes DK, Engelhard VH, Takahashi T, Riddell SR. Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling. Br J Haematol. 2003;123:671-675. (PubMed )

6. Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant. Br J Haematol. 2004; 124:629-635. ）(PubMed )

7. Kondo E, Akatsuka Y, Kuzushima K, Tsujimura K, Asakura S, Tajima K, Kagami Y, Kodera Y, Tanimoto M, Morishima Y, Takahashi T. Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles. Blood. 2004;103:630-638. ）A href=http://www.ncbi.nlm.nih.gov/pubmed/12947002>PubMed )
Other-10： 1. Nakajima H, Akatsuka Y. The Fifth Nagoya International Blood And Marrow Transplantation Symposium: unlimited possibilities of hematopoietic cell transplantation: lessons from the past and prospects for the future. Int J Hematol. 2004;79:200-204.
Research History [2004] (#11)
Papers-11： 1 Torikai H, Akatsuka Y, Miyazaki M, Warren EH 3rd, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. J Immunol. 173:7046-54, 2004. (PubMed )

2. Ishida T, Iida S, Akatsuka Y, Ishii T, Miyazaki M, Komatsu H, Inagaki H, Okada N, Fujita T, Shitara K, Akinaga S, Takahashi T, Utsunomiya A, Ueda R. The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/ lymphoma. Clin Cancer Res. 10: 7529-39, 2004.
Research History [2005] (#12)
Papers-12： 1) Kondo E, Akatsuka Y, Nawa A, Kuzushima K, Tsujimura K, Tanimoto M, Kodera Y, Morishima Y, Kuzuya K, Takahashi T. Retroviral vector backbone immunogenicity: identification of cytotoxic T-cell epitopes in retroviral vector-packaging sequences. Gene Ther. 12: 252-258, 2005. (PubMed )

2) A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation. Terakura S, Murata M, Nishida T, Emi N, Akatsuka Y, Riddell SR, Morishima Y, Kodera Y, Naoe T. Br J Haematol. 129(2): 221-228, 2005.
Research History [2006] (#13)
Papers-13： 1. Ito Y, Kondo E, Demachi-Okamura A, Akatsuka Y, Tsujimura K, Tanimoto M, Morishima Y, Takahashi T, Kuzushima K.. Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation. J Virol. 80: 883-890, 2006.

2. Terakura S, Murata M, Nishida T, Emi N, Akatsuka Y, Morishima Y, Kodera Y, Naoe T. Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients. Bone Marrow Transplant. 37: 381-386, 2006.

3. Demachi-Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K.. Epstein-Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies. Eur J Immunol. 36: 593-602, 2006.

4. Torikai H, Akatsuka Y, Miyazaki M, Tsujimura A, Yatabe Y, Kawase T, Nakao Y, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. The human cathepsin H gene encodes two novel minor histocompatibility antigen epitopes restricted by HLA-A*3101 and -A*3303. Br J Haematol. 134: 406-416, 2006. (PubMed )

5. Naota H, Miyahara Y, Okumura S, Kuzushima K, Akatsuka,Y, Hiasa A, Kitano S, Takahashi T, Yuta A, Majima Y, Shiku H. Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells. J Immunol Methods. 314: 54-66, 2006.

6. Akatsuka Y, Torikai H, Inamoto Y, Tsujimura K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. Bone marrow may be a reservoir of long-lived memory T cells specific for minor histocompatibility antigen. Br J Haematol. 135: 408-417, 2006.

7. Tsujimura K, Obata Y, Matsudaira Y, Nishida K, Akatsuka Y, Ito Y, Demachi-Okamura A, Kuzushima K, Takahashi T. Characterization of murine CD160+ CD8+ T lymphocytes. Immunol Lett. 106: 48-56, 2006.
Research History [2007] (#14)
Papers-14： 1. Morishima S, Akatsuka Y, Nawa A, Kondo E, Kiyono T, Torikai H, Nakanishi T, Ito Y, Tsujimura K, Iwata K, Ito K, Kodera Y, Morishima Y, Kuzushima K, Takahashi T. Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-gamma on the presentation of a cryptic epitope. Int J Cancer. 120: 594-604, 2007.(PubMed )

2. Morishima Y, Yabe T, Matsuo K, Kashiwase K, Inoko H, Saji H, Yamamoto K, Maruya E, Akatsuka Y, Onizuka M, Sakamaki H, Sao H, Ogawa S, Kato S, Juji T, Sasazuki T, Kodera Y; Japan Marrow Donor Program. Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. Biol Blood Marrow Transplant. 13: 315-328, 2007.

3. Ito Y, Demachi-Okamura A, Ohta R, Akatsuka Y, Nishida K, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K. Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells. J Gen Virol. 88: 770-780, 2007.

4. Torikai H, AkatsukaY( contributed equally), Miyauchi H, Terakura S, Onizuka M, Tsujimura K, Miyamura K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. The HLA-A*0201-restricted minor histocompatibility antigen HA-1H peptide can also be presented by another HLA-A2 subtype, A*0206. Bone Marrow Transplant. 40: 165-74, 2007. (PubMed )

5. Kawase T, Akatsuka Y, Torikai H, Morishima S, Oka A, Tsujimura A, Miyazaki M, Tsujimura K, Miyamura K, Ogawa S, Inoko H, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen. Blood.110: 1055-63, 2007. (PubMed )

6. Akatsuka Y, Morishima Y, Kuzushima K, Kodera Y, Takahashi T. Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions. Cancer Sci. 98:1139-1146, 2007. (PubMed )
Research History [2008] (#15)
Papers-15： 1. Kawase T, Nannya Y, Torikai H, Yamamoto G, Onizuka M, Morishima S, Tsujimura K, Miyamura K, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y. Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA. Blood. 111:3286-94, 2008.(PubMed )


2. Demachi-Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K. Epstein-Barr virus nuclear antigen 1-specific CD4+ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells. Cancer Sci, 99: 1633-1642, 2008.

3. Rosinski KV, Fujii N, Mito JK, Koo KK, Xuereb SM, Sala-Torra O, Gibbs JS, Radich JP, Akatsuka Y, Van den Eynde BJ, Riddell SR, Warren EH. DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. Blood, 111: 4817-4826, 2008.

4. Lu X, Kondo Y, Takamatsu H, Ohata K, Yamazaki H, Takami A, Akatsuka Y, Nakao S. CD16+ CD56- NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect. Eur J Haematol, 81: 18-25, 2008.

5. Torikai H, Akatsuka Y, Yatabe Y, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation. Int J Hematol, 87:467-473, 2008. (PubMed )

6. Watanabe K, Suzuki S, Kamei M, Toji S, Kawase T, Takahashi T, Kuzushima K, Akatsuka Y. CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy. Int J Hematol, 88: 311-320, 2008. (PubMed )

7. Shimato S, Natsume A, Wakabayashi T, Tsujimura K, Nakahara N, Ishii J, Ito M, Akatsuka Y, Kuzushima K, Yoshida J. Identification of a human leukocyte antigen-A24-restricted T-cell epitope derived from interleukin-13 receptor alpha2 chain, a glioma-associated antigen. J Neurosurg. 109:117-122, 2008.
Research History [2009] (#16)
Papers-16： 1. Kamei M, Nannya Y, Torikai H, Kawase T, Taura K, Inamoto Y, Takahashi T, Yazaki M, Morishima S, Tsujimura K, Miyamura K, Ito T, Togari H, Riddell SR, Kodera Y, Morisima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y. HapMap scanning of novel human minor histocompatibility antigens. Blood. 113:5041-8, 2009.(PubMed )

2. Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S. Frequent inactivation of A20 in B-cell lymphomas. Nature. 459:712-6, 2009.

3. Taniguchi K, Shimazaki C, Ochiai N, Maruya E, Akatsuka Y, Ashihara E, Maekawa T, Taniwaki M, Saji H. Modified ELISPOT assay may predict T-cell hyporesponsiveness to non-inherited maternal antigens. Int J Lab Hematol. Int J Lab Hematol. 32(1 Pt 1):e163-8, 2010.
Research History [2010] (#17)
Papers-17： 1. Warren EH, Fujii N, Akatsuka Y, Chaney CN, Mito JK, Loeb KR, Gooley TA, Brown ML, Koo KK, Rosinski KV, Ogawa S, Matsubara A, Appelbaum FR, Riddell SR. Therapy of relapsed leukemia after allogeneic hematopoietic cell transplant with T cells specific for minor histocompatibility antigens. Blood. 115:3869-78, 2010. (PubMed )

2. Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, Yagasaki H, Saji H, Kato M, Ogawa S, Kojima S.: Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation. Blood. 115:3158-3161, 2010.
(PubMed )

3. Yasukawa M, Nagai K, Fujiwara H, Ochi T, Akatsuka Y, Mineno J, and Shiku H.: Allo-HLA reactivity of leukemia-specific cytotoxic T lymphocytes Blood e-letter (19 April 2010).

4. Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T.:The Human Cytomegalovirus UL76 Gene Regulates the Level of Expression of the UL77 Gene. PLoS ONE 5: e11901,2010. (PubMed )

Research History [2011] (#18)
Papers-18： 1. An J, Fujiwara H, Suemori K, Niiya T, Azuma T, Tanimoto K, Ochi T, Akatsuka Y, Mineno J, Ozawa H, Ishikawa F, Kuzushima K, Yasukawa M. Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis. Int J Hematol. 93(2):176-85, 2011. PMID: 21229399. (PubMed )

2. Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y. Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci. 102(7):1281-6, 2011. PMID: 21466613.（学位論文の１部）(PubMed )

3. Suzuki S, Yoshikawa T, Hirosawa T, Shibata K, Kikkawa F, Akatsuka Y, Nakatsura T. Glypican-3 could be an effective target for immunotherapy combined with chemotherapy against ovarian clear cell carcinoma. Cancer Sci. 102(9):1622-9, 2011. PMID: 21668581. (PubMed )
Research History [2012] (#19)
Papers-19： 1. Yamamoto Y, Tsuzuki S, Akahori Y, Ukai Y, Sumitomo M, Murayama Y, Yamamoto K, Inaguma Y, Tokuda M, Abe A, Akatsuka Y, Emi N, Kurosawa Y. Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling. Cancer Sci. 103:350-9, 2012. PMID: 22049994. (PubMed )

2. Okanami Y, Tsujimura K, Mizuno S, Tabata M, Isaji S, Akatsuka Y, Kuzushima K, Takahashi T, Uemoto S. Intracellular interferon-gamma staining analysis of donor-specific T-cell responses in liver transplant recipients. Transplant Proc. 44:548-54, 2012. PMID: 22410067. (PubMed )

3. Ochsenreither S, Majeti R, Schmitt T, Stirewalt D, Keilholz U, Loeb KR, Wood B, Choi YE, Bleakley M, Warren EH, Hudecek M, Akatsuka Y, Weissman IL, Greenberg PD. Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. Blood. 119:5492-501, 2012. PMID: 22529286. (PubMed )

4. Yamamura T, Hikita J, Bleakley M, Hirosawa T, Sato-Otsubo A, Torikai H, Hamajima T, Nannya Y, Demachi-Okamura A, Maruya E, Saji H, Yamamoto Y, Takahashi T, Emi N, Morishima Y, Kodera Y, Kuzushima K, Riddell SR, Ogawa S, Akatsuka Y. HapMap SNP Scanner: an online program to mine SNPs responsible for cell phenotype. Tissue Antigens. 80:119-125, 2012. PMID: 22568758. (>PubMed )

5. Machino T, Okoshi Y, Miyake Y, Akatsuka Y, Chiba S. HLA-C Matching Status Does Not Affect Rituximab-Mediated Antibody-Dependent Cellular Cytotoxicity by Allogeneic Natural Killer Cells. Immunol Invest. 2012; 41(8):831-846. PMID: 22676066. (PubMed )

6. Demachi-Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K. Autophagy creates a CTL epitope that mimics tumor-associated antigens. PLoS One. 2012;7(10):e47126. PMID:23071732. (PubMed )

7. Tamanaka T, Oka Y, Fujiki F, Tsuboi A, Katsuhara A, Nakajima H, Hosen N, Nishida S, Lin YH, Tachino S, Akatsuka Y, Kuzushima K, Oji Y, Kumanogoh A, Sugiyama H. Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor. Anticancer Res. 2012; 32(12): 5201-9. PMID:23225417. (PubMed )
Research History [2013] (#20)
Papers-20： 1. Okamoto A, Yanada M, Inaguma Y, Tokuda M, Morishima S, Kanie T, Yamamoto Y, Tsuzuki M, Akatsuka Y, Mizuta S, Okamoto M, Emi N. Differences in outcome for consecutive patients with diffuse large B-cell lymphoma before and after the advent of rituximab: a single-center experience. Hematology. 2013; 18:74-80. PMID:23320957.

2. Kondo S, Demachi-Okamura A, Hirosawa T, Maki H, Fujita M, Uemura Y, Akatsuka Y, Yamamoto E, Shibata K, Ino K, Kikkawa F, Kuzushima K.An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules.
Hum Immunol. 2013; 74: 1103-1110. PMID: 23806269. (PubMed )

3. Adoptive transfer of genetically engineered WT1-specific cytotoxic T lymphocytes does not induce renal injury. Asai H, Fujiwara H, Kitazawa S, Kobayashi N, Ochi T, Miyazaki Y, Ochi F, Akatsuka Y, Okamoto S, Mineno J, Kuzushima K, Ikeda H, Shiku H, Yasukawa M. J Hematol Oncol. 2014;7:3. PMID: 24393438. (PubMed )
Research History [2015] (#22)
Papers-22： 1) Zhang R, Liu T, Senju S, Haruta M, Hirosawa N, Suzuki M, Tatsumi M, Ueda N, Maki H, Nakatsuka R, Matsuoka Y, Sasaki Y, Tsuzuki S, Nakanishi H, Araki R, Abe M, Akatsuka Y, Sakamoto Y, Sonoda Y, Nishimura Y, Kuzushima K, Uemura Y. Generation of mouse pluripotent stem cell-derived proliferating myeloid cells as an unlimited source of functional antigen-presenting cells. Cancer Immunol Res. 2015 Feb 11. pii: canimm.0117.2014. [Epub ahead of print] PMID: 25672396.(PubMed )

2) Matsuura H, Akatsuka Y, Muramatsu C, Isogai S, Sugiura Y, Arakawa S, Murayama M, Kurahashi M, Takasuga H, Oshige T, Yuba T, Mizuta S, Emi N. Evaluation of the potassium adsorption capacity of a potassium adsorption filter during rapid blood transfusion. Vox Sang. 2015 Mar 6. doi: 10.1111/vox.12242. [Epub ahead of print] PMID: 25754102.(PubMed )

3) Inaguma Y, Akatsuka Y*, Hosokawa K, Maruyama H, Okamoto A, Katagiri T, Shiraishi K, Murayama Y, Tsuzuki-Iba S, Mizutani Y, Nishii C, Yamamoto N, Demachi-Okamura A,2 Kuzushima K, Ogawa S, Emi N and Nakao S. Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against hematopoietic progenitor cells from a patient with severe aplastic anemia. Br J Haematol. 2016 Jan;172(1):131-4. PMID: 25929998.(PubMed )
*Corresponding author.

4) Yanada M, Okamoto A, Inaguma Y, Tokuda M, Morishima S, Kanie T, Yamamoto Y, Mizuta S, Akatsuka Y, Okamoto M, Emi N. The fate of patients with acute myeloid leukemia not undergoing induction chemotherapy. Int J Hematol. 2015 Mar 31. [Epub ahead of print] PMID: 25822047

5) Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T. Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection.
Bone Marrow Transplant. 2015 Jun 1. doi:10.1038/bmt.2015.119. [Epub ahead of print] PMID: 26030050.(PubMed )

6) Okamoto A, Yanada M, Inaguma Y, Tokuda M, Morishima S, Kanie T, Yamamoto Y, Mizuta S, Akatsuka Y, Yoshikawa T, Mizoguchi Y, Nakamura S, Okamoto M, Emi N.
The prognostic significance of EBV DNA load and EBER status in diagnostic specimens from diffuse large B-cell lymphoma patients. Hematol Oncol. 2015 Jul 14. doi: 10.1002/hon.2245. [Epub ahead of print] PMID: 26177728.

7) Yamada E, Demachi-Okamura A, Kondo S, Akatsuka Y, Suzuki S, Shibata K, Kikkawa F, Kuzushima K. Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs. Tissue Antigens. 2015 Sep;86(3):164-71. doi: 10.1111/tan.12607. Epub 2015 Jul 28. PMID: 26216489.(PubMed )

8) Okamoto A, Yanada M, Miura H, Inaguma Y, Tokuda M, Morishima S, Kanie T, Yamamoto Y, Mizuta S, Akatsuka Y, Yoshikawa T, Mizoguchi Y, Nakamura S, Okamoto M, Emi N. Prognostic significance of Epstein-Barr virus DNA detection in pretreatment serum in diffuse large B-cell lymphoma. Cancer Sci. 2015 Nov;106(11):1576-81. doi: 10.1111/cas.12812. Epub 2015 Oct 7. PMID: 26353084.

9) Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, Ogawa S; Japan Marrow Donor Program. Genome-wide surveillance of mismatched alleles for graft-versus-host disease in stem cell transplantation. Blood. 2015 Dec 17;126(25):2752-63. doi: 10.1182/blood-2015-03-630707. Epub 2015 Oct 2. PMID: 26432889.(PubMed )

10) Abe A, Yamamoto Y, Iba S, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Kanie T, Tsuzuki M, Akatsuka Y, Mizuta S, Okamoto M, Kameyama T, Mayeda A, Emi N. NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214. Cytogenet Genome Res. 2015;146(4):279-84. doi: 10.1159/000441464. Epub 2015 Oct 31. PMID: 26517539.
Research History [2016] (#23)
Papers-23： 1) Kobayashi S, Ueda Y, Nannya Y, Shibayama H, Tamura H, Ogata K, Akatsuka Y, Usuki K, Ito Y, Okada M, Suzuki T, Hata T, Matsuda A, Tohyama K, Kakumoto K, Koga D, Mitani K, Naoe T, Sugiyama H, Takaku F. Prognostic significance of Wilms tumor 1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.
Cancer Biomark. 2016 Mar 31;17(1):21-32. PMID: 27062571
.(PubMed )

2) Yanada M, Yamamoto Y, Iba S, Okamoto A, Inaguma Y, Tokuda M, Morishima S, Kanie T, Mizuta S, Akatsuka Y, Okamoto M, Emi N. TP53 mutations in older adults with acute myeloid leukemia. Int J Hematol. 2016 Apr;103(4):429-35.

3) Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S. Aberrant PD-L1 expression through 3-UTR disruption in multiple cancers. Nature. 2016 May 23;534(7607):402-6. doi: 10.1038/nature18294. PMID: 27281199.

4) Abe A, Yamamoto Y, Iba S, Okamoto A, Tokuda M, Inaguma Y, Yanada M, Morishima S, Kanie T, Tsuzuki M, Akatsuka Y, Mizuta S, Okamoto M, Kameyama T, Mayeda A, Emi N. NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214. Genes Chromosomes Cancer. 2016 Mar;55(3):242-50. doi: 10.1002/gcc.22327.PMID: 26542893.

Tue Feb 19 13:50:45 JST 2019

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