循環器
日本における先天性心疾患の割合は約100人に1人から1.5人へと増加傾向です。小児循環器グループでは、当院産科と協力の元、妊娠中期の始まり（在胎14-15週～）から胎児心エコーを行うことが可能で、可及的速やかな心疾患患児の管理を行っています。当院では現在、小児循環器の外科的な治療を行っていないため、出産早期に外科的な治療が必要と考えられる胎児では妊娠後期（在胎30週前後）に、適切な医療機関に母胎搬送しております。内科的な管理が優先される患児の場合は当院の周産母子センターで出産、管理を行っています。その後は、疾患により様々な経過を辿りますが、小児科外来を中心に、必要な場合は入院管理も行いながら適宜適切な内科的、外科的な治療を行っていきます。心内修復術が施行された患児や心不全、不整脈の治療を行っている患児が高校生になると、当院循環器内科、心臓血管外科、産婦人科などと協力して、成人先天性心疾患外来を通じて、生涯に渡る診療を行っていくことを目指しております。
2020年4月からは「小児循環器学会認定 小児循環器専門医修練施設群」に認定され、今後は小児科専門医取得後、最短3年目で小児循環器専門医受験資格を獲得できます。2021年4月からは「成人先天性心疾患学会認定 成人先天性心疾患専門医連携修練施設」の認定を目指して、現在準備中です。
研究に関しては、（１）心電図におけるHR variabilityを様々な疾患に応用した電気生理学的研究、（２）産科・新生児グループ・分子遺伝学研究室と協力して胎児・新生児循環の解析、遺伝学的解析、（３）各種小児心筋症の研究、特に拘束型心筋症の動物モデルの研究、（４）Canon Aplio i-900シリーズを用いた心機能解析、（５）川崎病の冠動脈発症に関する研究、を行っております。
2020年4月からは「小児循環器学会認定 小児循環器専門医修練施設群」に認定され、今後は小児科専門医取得後、最短3年目で小児循環器専門医受験資格を獲得できます。2021年4月からは「成人先天性心疾患学会認定 成人先天性心疾患専門医連携修練施設」の認定を目指して、現在準備中です。
研究に関しては、（１）心電図におけるHR variabilityを様々な疾患に応用した電気生理学的研究、（２）産科・新生児グループ・分子遺伝学研究室と協力して胎児・新生児循環の解析、遺伝学的解析、（３）各種小児心筋症の研究、特に拘束型心筋症の動物モデルの研究、（４）Canon Aplio i-900シリーズを用いた心機能解析、（５）川崎病の冠動脈発症に関する研究、を行っております。
スタッフ
- 畑忠善（ばんたね病院 臨床検査科 教授）
- 齋藤和由（講師）
- 内田英利（講師）
- 小島有紗（助教）
- 鈴木大次郎（岡崎医療センター 助教）
業績（過去3年間 英文）
Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- and Post-Diagnostic Phases in Children and Adolescents. Yoshinaga M, Horigome H, Ayusawa M, Yasuda K, Kogaki S, Doi S, Tateno S, Ohta K, Hokosaki T, Nishihara E, Iwamoto M, Sumitomo N, Ushinohama H, Izumida N, Tauchi N, Kato Y, Kato T, Chisaka T, Higaki T, Yoneyama T, Abe K, Nozaki Y, Komori A, Kawai S, Ninomiya Y, Tanaka Y, Nuruki N, Sonoda M, Ueno K, Hazeki D, Nomura Y, Sato S, Hirono K, Hosokawa S, Takechi F, Ishikawa Y, Hata T, Ichida F, Ohno S, Makita N, Horie M, Matsushima S, Tsutsui H, Ogata H, Takahashi H, Nagashima M. Circ J. 2021 Dec 24;86(1):118-127. doi: 10.1253/circj.CJ-21-0376. Epub 2021 Oct 6.
Sodium-containing versus sodium-trace preparations of IVIG for children with Kawasaki disease in the acute phase. Suzuki T, Michihata N, Aso S, Yoshikawa T, Saito K, Matsui H, Fushimi K, Yasunaga H. Eur J Pediatr. 2021 Nov;180(11):3279-3286. doi: 10.1007/s00431-021-04096-x. Epub 2021 May 10.
A double heterozygous variant in MYH6 and MYH7 associated with hypertrophic cardiomyopathy in a Japanese Family. Suzuki T, Saito K, Yoshikawa T, Hirono K, Hata Y, Nishida N, Yasuda K, Nagashima M. Journal of Cardiology Cases. 2021 Oct 20. doi: https://doi.org/10.1016/j.jccase.2021.09.01
Coronary Artery Z Score is Associated with Postoperative Outcomes in Patients with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery. Suzuki T, Saito K, Yoshikawa T, Okada N, Yasuda K, Murayama H. Pediatr Cardiol. 2021 Sep 29. doi: 10.1007/s00246-021-02741-8.
Diagnostic value of P-waves in children with idiopathic restrictive cardiomyopathy. Muraji S, Sumitomo N, Imamura T, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Yoshinaga M, Nakano S. Heart Vessels. 2021 Aug;36(8):1141-1150.
Myocardial repolarization time, J-point to T-peak and T-peak to T-end intervals, have different heart rate dependency and autonomic nerve interference in healthy prepubertal children. Kusuki K, Mizutani Y, Tsuchiya Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Hosoi M, Matsuura H, Sadanaga T, Hata T. J Electrocardiol. 2021 Jul-Aug 67: 119-123.
Reversible left ventricular noncompaction caused by hypertensive hydrocephalus: a pediatric case report. Kato R, Taneichi H, Takarada S, Okabe M, Miyao N, Nakaoka H, Ibuki K, Ozawa S, Adachi Y, Yoshimura N, Saito K, Ichida F, Hirono K. BMC Pediatr. 2021 Apr 28;21(1):205. doi: 10.1186/s12887-021-02680-6.
Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children. Imamura T, Sumitomo N, Muraji S, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Makiyama T, Yoshinaga M. Int J Cardiol. 2021 Jan 15;323:168-174.
A significance of school screening electrocardiogram in the patients with ventricular noncompaction. Hirono K, Miyao N, Yoshinaga M, Nishihara E, Yasuda K, Tateno S, Ayusawa M, Sumitomo N, Horigome H, Iwamoto M, Takahashi H, Sato S, Kogaki S, Ohno S, Hata T, et al. Heart Vessels. 2020 Jul;35(7):985-995. doi: 10.1007/s00380-020-01571-7.
Reliability of serological tests for COVID-19: comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. Fujigaki H, Takemura M, Osawa M, Sakurai A, Nakamoto K, Seto K, Fujita T, Hata T, Akiyama H, Doi Y, Saito K. Heliyon. 2020 Sep 10;6(9):e04929. doi: 10.1016/j.heliyon.2020.e04929. eCollection 2020 Sep.
Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children. Imamura T, Sumitomo N, Muraji S, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Makiyama T, Yoshinaga M. Int J Cardiol. 2020 Aug 30:S0167-5273(20)33715-3. doi: 10.1016/j.ijcard.2020.08.088. Online ahead of print.
High-dose versus low-dose intravenous immunoglobulin for treatment of children with Kawasaki disease weighing 25 kg or more. Suzuki T, Michihata N, Yoshikawa T, Hata T, Matsui H, Fushimi K, Yasunaga H. Eur J Pediatr. 2020 Aug 29. doi: 10.1007/s00431-020-03794-2. Online ahead of print.PMID: 32862279
QT Variability Index is Correlated with Autonomic Nerve Activity in Healthy Children. Kusuki H, Tsuchiya Y, Mizutani Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Kojima A, Uchida H, Kojima N, Saito K, Sadanaga T, Hata T. Pediatr Cardiol. 2020 Jun 22. doi: 10.1007/s00246-020-02399-8. Online ahead of print.
Evaluation of Perinatal Autonomic Development in Infants Using the QT/RR Variability Ratio. Mizutani Y, Kojima A, Tsuchiya Y, Kusuki H, Sugimoto K, Osakabe K, Ichino N, Fujino M, Saito K, Miyata M, Sadanaga T, Hata T. Fujita Med J. 2019
Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10. Hirono K, Saito K, Munkhsaikhan U, Xu F, Wang C, Lu L, Ichida F, Towbin JA, Purevjav E. Circ J. 2019 Jun 26. doi: 10.1253
Sodium-containing versus sodium-trace preparations of IVIG for children with Kawasaki disease in the acute phase. Suzuki T, Michihata N, Aso S, Yoshikawa T, Saito K, Matsui H, Fushimi K, Yasunaga H. Eur J Pediatr. 2021 Nov;180(11):3279-3286. doi: 10.1007/s00431-021-04096-x. Epub 2021 May 10.
A double heterozygous variant in MYH6 and MYH7 associated with hypertrophic cardiomyopathy in a Japanese Family. Suzuki T, Saito K, Yoshikawa T, Hirono K, Hata Y, Nishida N, Yasuda K, Nagashima M. Journal of Cardiology Cases. 2021 Oct 20. doi: https://doi.org/10.1016/j.jccase.2021.09.01
Coronary Artery Z Score is Associated with Postoperative Outcomes in Patients with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery. Suzuki T, Saito K, Yoshikawa T, Okada N, Yasuda K, Murayama H. Pediatr Cardiol. 2021 Sep 29. doi: 10.1007/s00246-021-02741-8.
Diagnostic value of P-waves in children with idiopathic restrictive cardiomyopathy. Muraji S, Sumitomo N, Imamura T, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Yoshinaga M, Nakano S. Heart Vessels. 2021 Aug;36(8):1141-1150.
Myocardial repolarization time, J-point to T-peak and T-peak to T-end intervals, have different heart rate dependency and autonomic nerve interference in healthy prepubertal children. Kusuki K, Mizutani Y, Tsuchiya Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Hosoi M, Matsuura H, Sadanaga T, Hata T. J Electrocardiol. 2021 Jul-Aug 67: 119-123.
Reversible left ventricular noncompaction caused by hypertensive hydrocephalus: a pediatric case report. Kato R, Taneichi H, Takarada S, Okabe M, Miyao N, Nakaoka H, Ibuki K, Ozawa S, Adachi Y, Yoshimura N, Saito K, Ichida F, Hirono K. BMC Pediatr. 2021 Apr 28;21(1):205. doi: 10.1186/s12887-021-02680-6.
Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children. Imamura T, Sumitomo N, Muraji S, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Makiyama T, Yoshinaga M. Int J Cardiol. 2021 Jan 15;323:168-174.
A significance of school screening electrocardiogram in the patients with ventricular noncompaction. Hirono K, Miyao N, Yoshinaga M, Nishihara E, Yasuda K, Tateno S, Ayusawa M, Sumitomo N, Horigome H, Iwamoto M, Takahashi H, Sato S, Kogaki S, Ohno S, Hata T, et al. Heart Vessels. 2020 Jul;35(7):985-995. doi: 10.1007/s00380-020-01571-7.
Reliability of serological tests for COVID-19: comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. Fujigaki H, Takemura M, Osawa M, Sakurai A, Nakamoto K, Seto K, Fujita T, Hata T, Akiyama H, Doi Y, Saito K. Heliyon. 2020 Sep 10;6(9):e04929. doi: 10.1016/j.heliyon.2020.e04929. eCollection 2020 Sep.
Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children. Imamura T, Sumitomo N, Muraji S, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Makiyama T, Yoshinaga M. Int J Cardiol. 2020 Aug 30:S0167-5273(20)33715-3. doi: 10.1016/j.ijcard.2020.08.088. Online ahead of print.
High-dose versus low-dose intravenous immunoglobulin for treatment of children with Kawasaki disease weighing 25 kg or more. Suzuki T, Michihata N, Yoshikawa T, Hata T, Matsui H, Fushimi K, Yasunaga H. Eur J Pediatr. 2020 Aug 29. doi: 10.1007/s00431-020-03794-2. Online ahead of print.PMID: 32862279
QT Variability Index is Correlated with Autonomic Nerve Activity in Healthy Children. Kusuki H, Tsuchiya Y, Mizutani Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Kojima A, Uchida H, Kojima N, Saito K, Sadanaga T, Hata T. Pediatr Cardiol. 2020 Jun 22. doi: 10.1007/s00246-020-02399-8. Online ahead of print.
Evaluation of Perinatal Autonomic Development in Infants Using the QT/RR Variability Ratio. Mizutani Y, Kojima A, Tsuchiya Y, Kusuki H, Sugimoto K, Osakabe K, Ichino N, Fujino M, Saito K, Miyata M, Sadanaga T, Hata T. Fujita Med J. 2019
Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10. Hirono K, Saito K, Munkhsaikhan U, Xu F, Wang C, Lu L, Ichida F, Towbin JA, Purevjav E. Circ J. 2019 Jun 26. doi: 10.1253