Shingo Hatakeyama   Kazuhiro Sugihara   Toshiaki K Shibata   Jun Nakayama   Tomoya O Akama   Naoaki Tamura   Shuk-Man Wong   Andrey A Bobkov   Yutaka Takano   Chikara Ohyama   Minoru Fukuda   Michiko N Fukuda   
Proc. Natl. Acad. Sci. USA (PNAS) 108(49) 19587-92 2011年12月 [査読有り]
Although numerous carbohydrates play significant roles in mammalian cells, carbohydrate-based drug discovery has not been explored due to the technical difficulty of chemically synthesizing complex carbohydrate structures. Previously, we identifie...
Shingo Hatakeyama   Kazuhiro Sugihara   Jun Nakayama   Tomoya O Akama   Shuk-Man Annie Wong   Hiroto Kawashima   Jianing Zhang   David F Smith   Chikara Ohyama   Minoru Fukuda   Michiko N Fukuda   
Proc. Natl. Acad. Sci. USA (PNAS) 106(9) 3095-100 2009年3月 [査読有り]
Cell surfaces of epithelial cancer are covered by complex carbohydrates, whose structures function in malignancy and metastasis. However, the mechanism underlying carbohydrate-dependent cancer metastasis has not been defined. Previously, we identi...
Kazuhiro Sugihara   Daijiro Sugiyama   James Byrne   Don P Wolf   Kevin P Lowitz   Yoichi Kobayashi   Maryam Kabir-Salmani   Daita Nadano   Daisuke Aoki   Shiro Nozawa   Jun Nakayama   Tomas Mustelin   Erkki Ruoslahti   Naoto Yamaguchi   Michiko N Fukuda   
Proc. Natl. Acad. Sci. USA (PNAS) 104(10) 3799-804 2007年3月 [査読有り]
During human embryo implantation, trophectoderm mediates adhesion of the blastocyst to the uterine epithelium. The rapid growth of the embryo and invasion of the maternal tissue suggest adhesion-induced activation of the embryonal cells. We show h...
Tomoya O Akama   Hiroaki Nakagawa   Kazuhiro Sugihara   Sonoko Narisawa   Chikara Ohyama   Shin-Ichiro Nishimura   Deborah A O'Brien   Kelley W Moremen   Jose Luis Millan   Michiko N Fukuda   
Science 295(5552) 124-7 2002年1月 [査読有り]
Spermatogenesis is a precisely regulated process in which the germ cells closely interact with Sertoli cells. The molecular basis of this cell-cell adhesion is unknown. Here, we demonstrate that targeted disruption of Man2a2, a gene encoding alpha...