Metastatic progression remains the major cause of death in human breast cancer. Cancer cells with cancer stem cell (CSC) properties drive initiation and growth of metastases at distant sites. We have previously established the breast cancer patien...
Everolimus (EVE), an inhibitor of mammalian target of rapamycin, is an emerging second-line therapeutic option for hormone therapy-resistant breast cancers. However, some patients do not respond to EVE, whereas in others it exacerbates the disease...
The Journal of nutritional biochemistry 82 108386-108386 2020年8月 [査読有り]
Maternal fructose consumption affects the metabolic functions of offspring later in life. However, the molecular mechanism remains poorly understood. Differences of microRNA expression profile and DNA methylation status are a candidate mechanism t...
Cancer cells with cancer stem cell (CSC) properties initiate both primary tumor formation and metastases at distant sites. Acquisition of CSC properties is highly associated with epigenetic alterations, including those mediated by microRNAs (miRNA...
Biochemistry and biophysics reports 20 100671-100671 2019年12月 [査読有り]
Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are...
① 抗がん剤(脂肪細胞に高発現するアディプシンを標的とすることでがん幹細胞性を抑制する抗がん剤。日本特許取得)
② ヒト腫瘍異種移植マウス(PDX)。乳がん、大腸がんなど
本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進セン
ター(fuji-san@fujita-hu.ac.jp)まで