Motegi H, Kufukihara K, Kitagawa S, Sekiguchi K, Hata J, Fujiwara H, Jinzaki M, Okano H, Nakamura M, Iguchi Y, Nakahara J. Non-lesional white matter changes depicted by q-space diffusional MRI correlate with clinical disabilities in multiple sclerosis. J Neurol Sci. 2024 Jan 15;456:122851. doi: 10.1016/j.jns.2023.122851. Epub 2023 Dec 20.
PMID: 38181653

Yamaguchi S, Irie J, Mitsuishi M, Uchino Y, Nakaya H, Takemura R, Inagaki E, Kosugi S, Okano H, Yasui M, Tsubota K, Hayashi K, Yoshino J, Itoh H. Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men. Endocr J. 2024 Feb 28;71(2):153-169. doi: 10.1507/endocrj.EJ23-0431. Epub 2024 Jan 6.
PMID: 38191197

Sawant N, Watanabe A, Ueda H, Okano H, Morita M. Incomplete accumulation of perilesional reactive astrocytes exacerbates wound healing after closed-head injury by increasing inflammation and BBB disruption. Exp Neurol. 2024 Apr;374:114700. doi: 10.1016/j.expneurol.2024.114700. Epub 2024 Jan 23.
PMID: 38272160

Supakul S, Oyama C, Hatakeyama Y, Maeda S, Okano H. Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models. Regen Ther. 2024 Jan 12;25:250-263. doi: 10.1016/j.reth.2023.12.018.
PMID: 38293585

Yano-Nashimoto S, Truzzi A, Shinozuka K, Murayama AY, Kurachi T, Moriya-Ito K, Tokuno H, Miyazawa E, Esposito G, Okano H, Nakamura K, Saito A, Kuroda KO. Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style. Commun Biol. 2024 Feb 20;7(1):212. doi: 10.1038/s42003-024-05875-6.
PMID: 38378797

Takada R, Toritsuka M, Yamauchi T, Ishida R, Kayashima Y, Nishi Y, Ishikawa M, Yamamuro K, Ikehara M, Komori T, Noriyama Y, Kamikawa K, Saito Y, Okano H, Makinodan M. Granulocyte macrophage colony-stimulating factor-induced macrophages of individuals with autism spectrum disorder adversely affect neuronal dendrites through the secretion of pro-inflammatory cytokines. Mol Autism. 2024 Feb 21;15(1):10. doi: 10.1186/s13229-024-00589-2.
PMID: 38383466

Supakul S, Murakami R, Oyama C, Shindo T, Hatakeyama Y, Itsuno M, Bannai H, Shibata S, Maeda S, Okano H. Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease. Inflamm Regen. 2024 Feb 28;44(1):8. doi: 10.1186/s41232-023-00310-5.
PMID: 38419091

Oshiro H, Hata J, Nakashima D, Oshiro R, Hayashi N, Haga Y, Hagiya K, Yoshimaru D, Okano H. Restricted diffusion characteristics in oscillating gradient spin echo with mesoscopic phantom. Heliyon. 2024 Feb 18;10(4):e26391. doi: 10.1016/j.heliyon.2024.e26391.
PMID: 38434080

Tashiro S, Shibata S, Nagoshi N, Zhang L, Yamada S, Tsuji T, Nakamura M, Okano H. Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies. Cells. 2024 Feb 27;13(5):412. doi: 10.3390/cells13050412.
PMID: 38474376

Okano Y, Kase Y, Suematsu Y, Nakamura M, Okano H. Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflamm Regen. 2024 Mar 13;44(1):10. doi: 10.1186/s41232-024-00322-9.
PMID: 38475915

Kaizuka T, Suzuki T, Kishi N, Tamada K, Kilimann MW, Ueyama T, Watanabe M, Shimogori T, Okano H, Dohmae N, Takumi T. Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development. Nat Commun. 2024 Mar 28;15(1):2496. doi: 10.1038/s41467-024-46529-9.
PMID: 38548776

Homma H, Yoshioka Y, Fujita K, Shirai S, Hama Y, Komano H, Saito Y, Yabe I, Okano H, Sasaki H, Tanaka H, Okazawa H. Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Commun Biol. 2024 Apr 9;7(1):413. doi:10.1038/s42003-024-06066-z.
PMID: 38594382

Sogabe K, Hata J, Yoshimaru D, Hagiya K, Okano HJ, Okano H. Structural MRI analysis of age-related changes and sex differences in marmoset brain volume. Neurosci Res. 2024 Sep;206:20-29. doi: 10.1016/j.neures.2024.04.003. Epub 2024 Apr 16.
PMID: 38636670

Murakami R, Watanabe H, Hashimoto H, Kashiwagi-Hakozaki M, Hashimoto T, Karch CM; Dominantly Inherited Alzheimer Network (DIAN),; Iwatsubo T, Okano H. Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models. J Neurosci. 2024 Jun 12;44(24):e1709232024. doi: 10.1523/JNEUROSCI.1709-23.2024.
PMID: 38649269 プレスリリース

Kanemura Y, Yamamoto A, Katsuma A, Fukusumi H, Shofuda T, Kanematsu D, Handa Y, Sumida M, Yoshioka E, Mine Y, Yamaguchi R, Okada M, Igarashi M, Sekino Y, Shirao T, Nakamura M, Okano H. Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Pluripotent Stem Cell-Derived Formation of Synaptic Structures in Rodent Ischemic Stroke Brains. Cells. 2024 Apr 12;13(8):671. doi: 10.3390/cells13080671.
PMID: 38667286

Hashimoto S, Nagoshi N, Nakamura M, Okano H. Clinical application and potential pluripotent effects of hepatocyte growth factor in spinal cord injury regeneration. Expert Opin Investig Drugs. 2024 Jul;33(7):713-720. doi:10.1080/13543784.2024.2360191. Epub 2024 May 29.
PMID: 38783527

Masano Y, Saegusa C, Ishikawa M, Matsunaga T, Okano H, Fujioka M. Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA. Stem Cell Res. 2024 Aug;78:103452. doi: 10.1016/j.scr.2024.103452. Epub 2024 May 25.
PMID: 38815527

Saegusa C, Mutai H, Saeki T, Matsuzaki S, Mizukoshi A, Kitajiri SI, Matsunaga T, Hosoya M, Okano H, Fujioka M. Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene. Stem Cell Res. 2024 Sep;79:103489. doi: 10.1016/j.scr.2024.103489. Epub 2024 Jul 8.
PMID: 39002249

Hayakawa-Yano Y, Furukawa T, Matsuo T, Ogasawara T, Nogami M, Yokoyama K, Yugami M, Shinozaki M, Nakamoto C, Sakimura K, Koyama A, Ogi K, Onodera O, Takebayashi H, Okano H, Yano M. Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2401531121. doi: 10.1073/pnas.2401531121. Epub 2024 Sep 3.
PMID: 39226364 プレスリリース

Yoshimaru D, Tsurugizawa T, Hata J, Muta K, Marusaki T, Hayashi N, Shibukawa S, Hagiya K, Okano H, Okano HJ. Similarity and characterization of structural and functional neural connections within species under isoflurane anesthesia in the common marmoset. Neuroimage. 2024 Oct 15;300:120854. doi: 10.1016/j.neuroimage.2024.120854. Epub 2024 Sep 14.
PMID: 39278381

Okuno T, Hata J, Kawai C, Okano H, Woodward A. A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State fMRI. J Neurosci. 2024 Nov 6;44(45):e0389242024. doi: 10.1523/JNEUROSCI.0389-24.2024.
PMID: 39299799

Okano Y, Okano H, Kase Y. Spinal cord injury regenerative therapy development: integration of design of experiments. Neural Regen Res. 2024 Sep 1;20(9):2571-2573. doi: 10.4103/NRR.NRR-D-24-00553. Epub 2024 Jul 29.
PMID: 39503418

Rusch RM, Inagaki E, Taniguchi H, Sakakura S, Tamai R, Nonaka H, Shimizu S, Sato S, Ogawa Y, Masatoshi H, Negishi K, Okano H, Shimmura S. Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation. Ocul Surf. 2024 Nov 13;34:523-534. doi: 10.1016/j.jtos.2024.11.001. Epub ahead of print.
PMID: 39542088

Nagoshi N, Hashimoto S, Okano H, Nakamura M. Regenerative medicine for spinal cord injury using induced pluripotent stem cells: from animals to humans. Pain. 2024 Nov 1;165(11S):S76-S81. doi: 10.1097/j.pain.0000000000003306.
PMID: 39560418

Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. A framework for neural organoids, assembloids and transplantation studies. Nature. 2024 Dec 9. doi: 10.1038/s41586-024-08487-6. Epub ahead of print.
PMID: 39653126

Itsuno M, Tanabe H, Sano E, Sasaki T, Oyama C, Bannai H, Saito K, Nakata K, Endoh-Yamagami S, Okano H, Maeda S. MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis. Regen Ther. 2024 Dec 24;28:201-213. doi: 10.1016/j.reth.2024.12.009.
PMID: 39811068

Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets.
Kurachi T, Shinozuka K, Yoshihara C, Yano-Nashimoto S, Murayama AY, Hata J, Haga Y, Okano H, Kuroda KO.
Commun Biol. 2023 Dec 5;6(1):1231. doi: 10.1038/s42003-023-05593-5.
PMID: 38052969

Urine-derived cells from the aged donor for the 2D/3D modeling of neural cells via iPSCs.
Supakul S, Hatakeyama Y, Leventoux N, Itsuno M, Numata N, Hiramine H, Morimoto S, Iwata A, Maeda S, Okano H.
Aging Brain. 2023 Nov 19;4:100101. doi: 10.1016/j.nbas.2023.100101. eCollection 2023.
PMID: 38045491

Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy.
Sakakura S, Inagaki E, Sayano T, Yamazaki R, Fusaki N, Hatou S, Hirayama M, Tsubota K, Negishi K, Okano H, Shimmura S.
Regen Ther. 2023 Nov 10;24:592-601. doi: 10.1016/j.reth.2023.11.001. eCollection 2023 Dec.
PMID: 38034859

Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis.
Okano H, Morimoto S, Kato C, Nakahara J, Takahashi S.
J Neurochem. 2023 Dec;167(5):603-614. doi: 10.1111/jnc.16005. Epub 2023 Nov 12.
PMID: 37952981

A shift of brain network hub after spinal cord injury.
Matsubayashi K, Shinozaki M, Hata J, Komaki Y, Nagoshi N, Tsuji O, Fujiyoshi K, Nakamura M, Okano H.
Front Mol Neurosci. 2023 Oct 17;16:1245902. doi: 10.3389/fnmol.2023.1245902. eCollection 2023.
PMID: 37915973

Proteomic characterization of aging-driven changes in the mouse brain by co-expression network analysis.
Tsumagari K, Sato Y, Aoyagi H, Okano H, Kuromitsu J.
Sci Rep. 2023 Oct 24;13(1):18191. doi: 10.1038/s41598-023-45570-w.
PMID: 37875604

Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation.
Suematsu Y, Nagoshi N, Shinozaki M, Kase Y, Saijo Y, Hashimoto S, Shibata T, Kajikawa K, Kamata Y, Ozaki M, Yasutake K, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H.
Inflamm Regen. 2023 Oct 16;43(1):50. doi: 10.1186/s41232-023-00298-y.
PMID: 37845736 プレスリリース

Regenerative medicine strategies for chronic complete spinal cord injury.
Hashimoto S, Nagoshi N, Nakamura M, Okano H.
Neural Regen Res. 2024 Apr;19(4):818-824. doi: 10.4103/1673-5374.382230.
PMID: 37843217

Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis.
Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, Takubo K, Kubota Y.
Nat Cell Biol. 2023 Oct;25(10):1415-1425. doi: 10.1038/s41556-023-01240-7. Epub 2023 Oct 5.
PMID: 37798545

Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Abe Y, Yagishita S, Sano H, Sugiura Y, Dantsuji M, Suzuki T, Mochizuki A, Yoshimaru D, Hata J, Matsumoto M, Taira S, Takeuchi H, Okano H, Ohno N, Suematsu M, Inoue T, Nambu A, Watanabe M, Tanaka KF.
Cell Rep Med. 2023 Oct 17;4(10):101208. doi: 10.1016/j.xcrm.2023.101208. Epub 2023 Sep 28.
PMID: 37774703

Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study.
Sasaki T, Nishimoto Y, Hirata T, Abe Y, Hirose N, Takayama M, Takebayashi T, Okano H, Arai Y.
Elife. 2023 Sep 28;12:e86309. doi: 10.7554/eLife.86309.
PMID: 37768324

The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration.
Ono-Minagi H, Nohno T, Serizawa T, Usami Y, Sakai T, Okano H, Ohuchi H.
Int J Mol Sci. 2023 Sep 5;24(18):13692. doi: 10.3390/ijms241813692.
PMID: 37761995

Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines.
Yokota M, Yoshino Y, Hosoi M, Hashimoto R, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M.
Front Cell Dev Biol. 2023 Sep 8;11:1171440. doi: 10.3389/fcell.2023.1171440. eCollection 2023.
PMID: 37745304

Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice.
Katada Y, Yoshida K, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Kandori H, Tsubota K, Kurihara T.
iScience. 2023 Aug 25;26(10):107716. doi: 10.1016/j.isci.2023.107716. eCollection 2023 Oct 20.
PMID: 37720108

Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing.
Yoshimatsu S, Okahara J, Yoshie J, Igarashi Y, Nakajima R, Sanosaka T, Qian E, Sato T, Kobayashi H, Morimoto S, Kishi N, Pillis DM, Malik P, Noce T, Okano H.
Cell Rep Methods. 2023 Sep 25;3(9):100590. doi: 10.1016/j.crmeth.2023.100590. Epub 2023 Sep 14.
PMID: 37714158

Gene therapy using genome-edited iPS cells for targeting malignant glioma.
Tamura R, Miyoshi H, Imaizumi K, Yo M, Kase Y, Sato T, Sato M, Morimoto Y, Sampetrean O, Kohyama J, Shinozaki M, Miyawaki A, Yoshida K, Saya H, Okano H, Toda M.
Bioeng Transl Med. 2022 Sep 10;8(5):e10406. doi: 10.1002/btm2.10406. eCollection 2023 Sep.
PMID: 37693056

Distribution of macrophages in the developing cochlea of the common marmoset, a primate model animal.
Hosoya M, Kitama T, Shimanuki MN, Nishiyama T, Oishi N, Okano H, Ozawa H.
Front Immunol. 2023 Aug 22;14:1229414. doi: 10.3389/fimmu.2023.1229414. eCollection 2023.
PMID: 37675123

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.
Watanabe H, Murakami R, Tsumagari K, Morimoto S, Hashimoto T, Imaizumi K, Sonn I, Yamada K, Saito Y, Murayama S, Iwatsubo T, Okano H.
Stem Cell Reports. 2023 Aug 14:S2213-6711(23)00301-6. doi: 10.1016/j.stemcr.2023.08.002. Online ahead of print.
PMID: 37657448 プレスリリース

Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula.
Kobayashi H, Ueda K, Morimoto S, Ishikawa M, Leventoux N, Sasaki R, Hirokawa Y, Kokubo Y, Okano H.
Neurol Sci. 2023 Aug 24. doi: 10.1007/s10072-023-07000-7. Online ahead of print.
PMID: 37615876

A Review of Treatment Methods Focusing on Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation for Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Nakamura M, Okano H, Nagoshi N.
Medicina (Kaunas). 2023 Jul 1;59(7):1235. doi: 10.3390/medicina59071235.
PMID: 37512047

Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal.
Hosoya M, Iwabu K, Kitama T, Nishiyama T, Oishi N, Okano H, Ozawa H.
Sci Rep. 2023 Jul 21;13(1):11789. doi: 10.1038/s41598-023-39003-x.
PMID: 37479821

LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Li D, Johmura Y, Morimoto S, Doi M, Nakanishi K, Ozawa M, Tsunekawa Y, Inoue-Yamauchi A, Naruse H, Matsukawa T, Takeshita Y, Suzuki N, Aoki M, Nishiyama A, Zeng X, Konishi C, Suzuki N, Nishiyama A, Harris AS, Morita M, Yamaguchi K, Furukawa Y, Nakai K, Tsuji S, Yamazaki S, Yamanashi Y, Shimada S, Okada T, Okano H, Toda T, Nakanishi M.
Nat Aging. 2023 Aug;3(8):1001-1019. doi: 10.1038/s43587-023-00464-4. Epub 2023 Jul 20.
PMID: 37474791

Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.
Kawamura Y, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T, Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K.
EMBO J. 2023 Aug 15;42(16):e111133. doi: 10.15252/embj.2022111133. Epub 2023 Jul 11.
PMID: 37431790

The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain.
Skibbe H, Rachmadi MF, Nakae K, Gutierrez CE, Hata J, Tsukada H, Poon C, Schlachter M, Doya K, Majka P, Rosa MGP, Okano H, Yamamori T, Ishii S, Reisert M, Watakabe A.
PLoS Biol. 2023 Jun 29;21(6):e3002158. doi: 10.1371/journal.pbio.3002158. eCollection 2023 Jun.
PMID: 37384809

Mapping of Notch signaling in the developing organ of Corti in common marmosets.
Hosoya M, Fujioka M, Okano H, Ozawa H.
Front Neuroanat. 2023 Jun 7;17:1188886. doi: 10.3389/fnana.2023.1188886. eCollection 2023.
PMID: 37351521

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.
Katada Y, Kunimi H, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tanaka KF, Tsubota K, Kurihara T.
Mol Ther Methods Clin Dev. 2023 May 12;30:1-13. doi: 10.1016/j.omtm.2023.05.011. eCollection 2023 Sep 14.
PMID: 37324975

Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms.
Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H.
Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721. Epub 2023 Jun 14.
PMID: 37315111

Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation.
Isoda M, Sanosaka T, Tomooka R, Mabuchi Y, Shinozaki M, Andoh-Noda T, Banno S, Mizota N, Yamaguchi R, Okano H, Kohyama J.
Commun Biol. 2023 Jun 7;6(1):611. doi: 10.1038/s42003-023-04995-9.
PMID: 37286713

Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H.
Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017.
PMID: 37267913 プレスリリース

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling.
Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Shimul RI, Niwa JI, Katsuno M, Sobue G, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y.
Sci Rep. 2023 May 25;13(1):8146. doi: 10.1038/s41598-023-34445-9.
PMID: 37231024

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain.
Watakabe A, Skibbe H, Nakae K, Abe H, Ichinohe N, Rachmadi MF, Wang J, Takaji M, Mizukami H, Woodward A, Gong R, Hata J, Van Essen DC, Okano H, Ishii S, Yamamori T.
Neuron. 2023 May 9:S0896-6273(23)00338-0. doi: 10.1016/j.neuron.2023.04.028. Online ahead of print.
PMID: 37196659

Dissecting calvarial bones and sutures at single-cell resolution.
Li B, Li J, Fan Y, Zhao Z, Li L, Okano H, Ouchi T.
Biol Rev Camb Philos Soc. 2023 May 12. doi: 10.1111/brv.12975. Online ahead of print.
PMID: 37171117

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.
Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group.
J Neurol Neurosurg Psychiatry. 2023 May 4:jnnp-2022-330851. doi: 10.1136/jnnp-2022-330851. Online ahead of print.
PMID: 37142397

Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes.
Kondo T, Ebinuma I, Tanaka H, Nishikawa Y, Komiya T, Ishikawa M, Okano H.
Int J Mol Sci. 2023 Apr 10;24(8):6987. doi: 10.3390/ijms24086987.
PMID: 37108151

Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range.
Hata J, Nakae K, Tsukada H, Woodward A, Haga Y, Iida M, Uematsu A, Seki F, Ichinohe N, Gong R, Kaneko T, Yoshimaru D, Watakabe A, Abe H, Tani T, Hamda HT, Gutierrez CE, Skibbe H, Maeda M, Papazian F, Hagiya K, Kishi N, Ishii S, Doya K, Shimogori T, Yamamori T, Tanaka K, Okano HJ, Okano H.
Sci Data. 2023 Apr 27;10(1):221. doi: 10.1038/s41597-023-02121-2.
PMID: 37105968 プレスリリース

The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: the second phase of the archive of digital records.
Sakai T, Hata J, Shintaku Y, Ohta H, Sogabe K, Mori S, Miyabe-Nishiwaki T, Okano HJ, Hamada Y, Hirabayashi T, Minamimoto T, Sadato N, Okano H, Oishi K.
Neuroimage. 2023 Apr 7:120096. doi: 10.1016/j.neuroimage.2023.120096. Online ahead of print.
PMID: 37031828 プレスリリース

Neuroprotective effects of genome-edited human iPS cell-derived neural stem/progenitor cells on traumatic brain injury.
Imai R, Tamura R, Yo M, Sato M, Fukumura M, Takahara K, Kase Y, Okano H, Toda M.
Stem Cells. 2023 Apr 8:sxad028. doi: 10.1093/stmcls/sxad028. Online ahead of print.
PMID: 37029780 プレスリリース

A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1.
Qian E, Uemura M, Kobayashi H, Nakamura S, Ozawa F, Yoshimatsu S, Ishikawa M, Onodera O, Morimoto S, Okano H.
Inflamm Regen. 2023 Apr 3;43(1):23. doi: 10.1186/s41232-023-00273-7.
PMID: 37009886

Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids.
Kodera T, Takeuchi RF, Takahashi S, Suzuki K, Kassai H, Aiba A, Shiozawa S, Okano H, Osakada F.
Biochem Biophys Res Commun. 2023 May 21;657:119-127. doi: 10.1016/j.bbrc.2023.03.019. Epub 2023 Mar 11.
PMID: 37002985

Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review.
Inoue M, Yamaguchi R, He CCJ, Ikeda A, Okano H, Kohyama J.
Stem Cell Investig. 2023 Mar 10;10:6. doi: 10.21037/sci-2022-037. eCollection 2023.
PMID: 36970397

The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D cultures.
Kase Y, Sonn I, Goto M, Murakami R, Sato T, Okano H.
Exp Neurol. 2023 Mar 11;363:114379. doi: 10.1016/j.expneurol.2023.114379. Online ahead of print.
PMID: 36914084

Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.
Tamura R, Iwanami A, Ohara K, Nishimoto M, Pareira ES, Miwa T, Tsuzaki N, Kuranari Y, Morimoto Y, Toda M, Okano H, Nakamura M, Yoshida K, Sasaki H.
Brain Tumor Pathol. 2023 Mar 9. doi: 10.1007/s10014-023-00453-w. Online ahead of print.
PMID: 36892668
Influence of Diffusion Time and Temperature on Restricted Diffusion Signal: A Phantom Study.
Oshiro H, Hata J, Nakashima D, Hayashi N, Haga Y, Hagiya K, Yoshimaru D, Okano H.
Magn Reson Med Sci. 2023 Feb 8. doi: 10.2463/mrms.mp.2022-0103. Online ahead of print.
PMID: 36754420

Epigenetic profile of Japanese supercentenarians: a cross-sectional study.
Komaki S, Nagata M, Arai E, Otomo R, Ono K, Abe Y, Ohmomo H, Umekage S, Shinozaki NO, Hachiya T, Sutoh Y, Otsuka-Yamasaki Y, Arai Y, Hirose N, Yoneyama A, Okano H, Sasaki M, Kanai Y, Shimizu A.
Lancet Healthy Longev. 2023 Feb;4(2):e83-e90. doi: 10.1016/S2666-7568(23)00002-8.
PMID: 36738748

Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury.
Hashimoto S, Nagoshi N, Shinozaki M, Nakanishi K, Suematsu Y, Shibata T, Kawai M, Kitagawa T, Ago K, Kamata Y, Yasutake K, Koya I, Ando Y, Minoda A, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H.
Biomaterials. 2023 Apr;295:122002. doi: 10.1016/j.biomaterials.2023.122002. Epub 2023 Jan 26.
PMID: 36736008 プレスリリース

Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury.
Shibata T, Tashiro S, Shibata S, Shinozaki M, Shindo T, Hashimoto S, Kawai M, Kitagawa T, Ago K, Matsumoto M, Nakamura M, Okano H, Nagoshi N.
Stem Cells Transl Med. 2023 Mar 3;12(2):83-96. doi: 10.1093/stcltm/szac089.
PMID: 36647673 プレスリリース

Generation of two induced pluripotent stem cell lines from individuals without auditory disorders.
Okura S, Ishii H, Suzuki A, Saegusa C, Fujiki K, Sugano K, Suzuki N, Saeki T, Matsuzaki S, Ozawa H, Fujioka M, Hosoya M, Okano H.
Stem Cell Res. 2023 Mar;67:103017. doi: 10.1016/j.scr.2023.103017. Epub 2023 Jan 4.
PMID: 36630839