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成果報告


 当拠点を利用して発表された研究論文リストです。

2020年

  1. Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice. Ryuichi Nakajima, Satoko Hattori, Teppei Funasaka, Freesia L. Huang, *Tsuyoshi Miyakawa. Neuropsychopharmacol Rep. 2020 Dec. doi:10.1002/npr2.12150.

  2. Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons. Uyeda A, Onishi K, Hirayama T, Hattori S, Miyakawa T, Yagi T, Yamamoto N, *Sugo N. J Neurosci. 2020 Nov. doi: 10.1523/JNEUROSCI.0319-20.2020.

  3. Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning. *Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa, *Keiichi I. Nakayama. Mol Brain. 2020 Nov. 13: 146. doi: 10.1186/s13041-020-00693-3.

  4. Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice. Arima-Yoshida F, Raveau M, Shimohata A, Amano K, Fukushima A, Watanave M, Kobayashi S, Hattori S, Usui M, Sago H, Mataga N, Miyakawa T, *Yamakawa K, *Manabe T. Sci Rep. 2020 Aug. 10: 14187. doi: 10.1038/s41598-020-71085-9.

  5. Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model. Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata JI, Niikura T, Yasui M. Acta Neuropathol Commun. 2020 May. 8(1):67. doi: 10.1186/s40478-020-00936-3.

  6. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. Nakagawa T, Hattori S, Nobuta R, Kimura R, Nakagawa M, Matsumoto M, Nagasawa Y, Funayama R, Miyakawa T, Inada T, Osumi N, Nakayama KI, *Nakayama K. iScience. 2020 Apr. 23(4):101030. doi: 10.1016/j.isci.2020.101030.

  7. Tsukushi is essential for the development of the inner ear. Tsukushi is essential for the development of the inner ear. Miwa T, Ohta K, Ito N, Hattori S, Miyakawa T, Takeo T, Nakagata N, Song WJ, Minoda R. Mol Brain. 2020 Mar. 13(1):29. doi.org/10.1186/s13041-020-00570-z.

2019年

  1. Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1. Isokawa M, *Sassa T, Hattori S, Miyakawa T, Kihara A. FASEB Bioadv. 2019 Nov. 1(12):747-759. doi.org/10.1096/fba.2019-00067.

  2. Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice. Shoji H, *Miyakawa T. Neuropsychopharmacol Rep. 2019 Dec. doi: 10.1002/npr2.12093.

  3. Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity. Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, *Yamakawa K. Mol Autism. 2019 Mar. 10:15. doi: 10.1186/s13229-019-0265-5.

  4. Age-related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program. Shoji H, *Miyakawa T. Neuropsychopharmacol Rep. 2019 Feb. 39(2). doi: 10.1002/npr2.12052. [Epub ahead of print]

  5. Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice. Nakajima R, Takao K, Hattori S, Shoji H, Komiyama NH, Grant SGN, *Miyakawa T. Neuropsychopharmacol Rep. 2019 Jul. 39(3). doi: 10.1002/npr2.12073.

  6. Open source code for behavior analysis in rodents. Hattori S, Okumura Y, Takao K, Yamaguchi Y, *Miyakawa T. Neuropsychopharmacol Rep. 2019 Jan. 39(3) 67-69. doi: 10.1002/npr2.12047. [Epub ahead of print]

  7. Acquired expression of mutant Mitofusin 2 causes progressive neurodegeneration and abnormal behavior. *Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Mito T, Matsumoto H, Miyakawa T, Nakada K. J Neurosci. 2019 Jan. 39 (9) 1588-1604. pii: 2139-18. doi: 10.1523/JNEUROSCI.2139-18.2018. [Epub ahead of print]

2018年

  1. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. *Katano T, Takao K, Abe M, Yamazaki M, Watanabe M, Miyakawa T, Sakimura K, Ito S. Mol Brain. 2018 Oct. 11(1):63. doi.org/10.1186/s13041-018-0407-2.

  2. Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. *Kobayashi K, Takagi T, Ishii S, Suzuki H, Miyakawa T. Mol Brain. 2018 Oct. 11(1):56. doi: 10.1186/s13041-018-0400-9.

  3. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Andoh C, Nishitani N, Hashimoto E, Nagai Y, Takao K, Miyakawa T, Nakagawa T, Mori Y, Nagayasu K, *Shirakawa H, Kaneko S. Brain Research. 2019 Feb. pii: S0006-8993(18)30496-7. 1704:68-77. doi: 10.1016/j.brainres.2018.09.031. (Epub ahead 2018 Sep)

  4. Comprehensive behavioral analysis of indoleamine 2,3-dioxygenase knockout mice. Hirata N, Hattori S, Shoji H, Funakoshi H, *Miyakawa T. Neuropsychopharmacol Rep. 2018 Sep. 38(3):133-144. doi: 10.1002/npr2.12019.

  5. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. Kanetake T, *Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, *Kihara A. FASEB J. 2018 Dec. 7:fj201800291R. doi: 10.1096/fj.201800291R.

  6. Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study. Shoji H, *Miyakawa T. Mol Brain. 2018 Jul. 11(1):42. doi: 10.1186/s13041-018-0382-7.

  7. Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein. Hagihara H, Fujita M, Umemori J, Hashimoto M, *Miyakawa T. Mol Brain. 2018 Jul. 11(1):38. doi: 10.1186/s13041-018-0378-3

  8. Dissociated Role of D-Serine in Extinction During Consolidation vs. Reconsolidation of Context Conditioned Fear. Inoue R, Talukdar G, Takao K, Miyakawa T, *Mori H. Front Mol Neurosci.2018 May. 11:161. doi: 10.3389/fnmol.2018.00161.

  9. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain. Maeta K, Hattori S, Ikutomo J, Edamatsu H, Bilasy SE, Miyakawa T, *Kataoka T. Mol Brain. 2018 May. 11(1):27. doi: 10.1186/s13041-018-0370-y.

  10. Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory. Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, *Tanaka T. PLoS One. 2018 Apr. 13(4):e0196587. doi: 10.1371/journal.pone.0196587.

  11. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Hattori S, Takao K, Funakoshi H, *Miyakawa T. Neuropsychopharmacol Rep. 2018 Jan. doi: 10.1002/npr2.12006.

  12. Decreased brain pH as a shared endophenotype of psychiatric disorders. Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, *Miyakawa T. Neuropsychopharmacol. 2017 Aug. 43, 459–468. doi: 10.1038/npp.2017.167.

  13. Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice. Shoji H, Irino Y, Yoshida M, *Miyakawa T. Neuropsychopharmacol Rep. 2018 Jan. doi: 10.1002/npr2.12002.

2017年


  1. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Yoshioka N, Miyata S, Tamada A, Watanabe Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, *Igarashi M. Mol Brain. 2017 Oct. 10(1):47. doi: 10.1186/s13041-017-0328-5.

  2. Arid1b haploinsufficiency causes abnormal brain gene expression and autism-related behaviors in mice. Shibutani M, Horii T, Shoji H, Morita S, Kimura M, Terawaki N, Miyakawa T, *Hatada I. Int J Mol Sci. 2017 Aug. 18(9), 1872. doi:10.3390/ijms18091872.

  3. Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice. Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, *Tomiyama T. Acta Neuropathol Commun.2017 Jul. 5(1):59. doi: 10.1186/s40478-017-0461-5.

  4. Comprehensive behavioral analysis of activating transcription factor 5-deficient mice. *Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y. Front Behav Neurosci.2017 Jul. 11:125. doi: 10.3389/fnbeh.2017.00125.

  5. Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice. *Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, *Takeichi M. Sci Rep. 2017 Jul. 7(1):5801. doi: 10.1038/s41598-017-06374-x.

  6. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, *Hashimoto H, Shirahige K, *Yamashita T. J Exp Med. 2017 May. 214(5):1431-1452. doi: 10.1084/jem.20161517.

  7. Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K. Exp Neurol. 2017 Jul. pii: S0014-4886(17)30069-9. doi: 10.1016/j.expneurol.2017.03.009.

  8. Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis. Ueda H, Sasaki K, Halder SK, Dequchi Y, Takao K, Miyakawa T, Tajima A. J Neurochem. 2017 Apr. pii: S0014-4886(17)30069-9. doi: 10.1111/jnc.13963.

2016年


  1. QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T. PLoS One. 2016 Nov 11;11(11):e0164716. doi: 10.1371/journal.pone.0164716.

  2. Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice. Morishita Y, Yoshioka Y, Takimura Y, Shimizu Y, Namba Y, Nojiri N, Ishizaka T, Takao K, Yamashita F, Takuma K, Ago Y, Nagano K, Mukai Y, Kamada H, Tsunoda S, Saito S, Matsuda T, Hashida M, Miyakawa T, Higashisaka K, Tsutsumi Y. ACS Nano. 2016 Aug 7. 10(9):8180-91. doi: 10.1021/acsnano.6b01782.

  3. CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI. Nature. 2016 Sep 7; 537: 675–679. doi: 10.1038/nature19357.

  4. Cohort Removal Induces Changes in Body Temperature, Pain Sensitivity, and Anxiety-Like Behavior. Takao K, Shoji H, Hattori S, Miyakawa T. Front Behav Neurosci. 2016 Jun 3;10:99. doi: 10.3389/fnbeh.2016.00099. eCollection 2016.

  5. Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders. Sakai K, Shoji H, Kohno T, Miyakawa T, Hattori M. Sci Rep. 2016 Jun 27;6:28636. doi: 10.1038/srep28636.

  6. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Ip JY, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, Abe T, Takao K, Miyakawa T, Blencowe BJ, Nakagawa S. Sci Rep. 2016 Jun 2;6:27204. doi: 10.1038/srep27204.

  7. Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery. Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A. J Biol Chem. 2016 May 27;291(22):11676-88. doi: 10.1074/jbc.M116.714030. Epub 2016 Apr 6.

  8. Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model. Hagihara H, Horikawa T, Nakamura HK, Umemori J, Shoji H, Kamitani Y, Miyakawa T. Cell Rep. 2016 Mar 29;14(12):2784-96. doi: 10.1016/j.celrep.2016.02.067.

  9. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Ohashi R, Takao K, Miyakawa T, Shiina N. Sci Rep. 2016 Feb 11;6:20775. doi: 10.1038/srep20775.

  10. Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse. Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A. Mol Brain. 2016 Feb 9;9(1):15. doi: 10.1186/s13041-016-0196-4.

  11. Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. Shoji H, Takao K, Hattori S, Miyakawa T. Mol Brain. 2016 Jan 28;9(1):11. doi: 10.1186/s13041-016-0191-9.

  12. Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders. Imai H, Shoji H, Ogata M, Kagawa Y, Owada Y, Miyakawa T, Sakimura K, Terashima T, Katsuyama Y. Cereb Cortex. 2016 Jan 12. pii: bhv334. doi: 10.1093/cercor/bhv334.

2015年

  1. Comprehensive Behavioral Analysis of Male Ox1r (-/-) Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior. Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T. Front Behav Neurosci. 2015 Dec 10;9:324. doi: 10.3389/fnbeh.2015.00324.

  2. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M. Nat Commun. 2015 Dec 10;6:10090. doi:10.1038/ncomms10090.

  3. TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y. Pflugers Arch. 2015 Dec;467(12):2495-507. doi: 10.1007/s00424-015-1726-0.

  4. Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. Nakao A, Miki T, Shoji H, Nishi M, Takeshima H, Miyakawa T, Mori Y. Front Behav Neurosci. 2015 Jun 16;9:141. doi: 10.3389/fnbeh.2015.00141.

  5. IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Kawaai K, Mizutani A, Shoji H, Ogawa N, Ebisui E, Kuroda Y, Wakana S, Miyakawa T, Hisatsune C, Mikoshiba K. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5515-20. doi: 10.1073/pnas.1503310112.