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ホーム >  研究部門紹介 >  神経・腫瘍のシグナル解析プロジェクト研究部門

神経・腫瘍のシグナル解析プロジェクト研究部門


神経・腫瘍のシグナル解析プロジェクト部門ホームページ

生体内で細胞は、細胞内外の情報を受け取り、隣り合う細胞や細胞外の基質と接着することで、特有の形態を呈し極性を獲得している。これらの過程は細胞が臓器や組織で特有の機能を発揮するために必須であり、生命活動の根本とも言える。これらの過程に異常が生じると精神神経疾患、癌、循環器疾患など多様な疾患が引き起こされる。すなわち、細胞形態、運動、接着、極性の制御機構を解明することは、生物の基本的な成り立ちを明らかにするだけでなく、様々な疾患の原因や治療法を確立する上で欠くことができない。我々の研究室では、細胞の形態、運動、接着、極性の分子機構を解明することにより、精神神経疾患、癌、循環器疾患の病態を細胞レベルから解き明かすことを目標にしている。


研究内容

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代表的な業績

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20. Hamaguchi, T., Nakamuta, S., Funahashi, Y., Takano, T., Nishioka, T., Hasanuzzaman, SM., Yura, Y., Kaibuchi, K., and Amano, M. In vivo Screening for Substrates of Protein Kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. Cell Struct Funct 40(1):1-12. (2015)

21. Namba, T., Kibe, Y., Funahashi, Y., Nakamuta, S., Takano, T., Ueno, T., Shimada, A., Kozawa, S., Okamoto, M., Shimoda, Y., Oda, K., Wada, Y., Masuda, T., Sakakibara, A., Igarashi, M., Miyata, T., Faivre-Sarrailh, C., Takeuchi, K., and Kaibuchi, K. Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron 81, 814-829. (2014)

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24. Funahashi, Y., Namba, T., Fujisue, S., Itoh, N., Nakamuta, S., Kato, K., Shimada, A., Xu, C., Shan, W., Nishioka, T., and Kaibuchi, K. ERK2-mediated phosphorylation of Par3 regulates neuronal polarization. J Neurosci 33, 13270-13285. (2013)

25. Nakayama, M., Nakayama, A., van Lessen, M., Yamamoto, H., Hoffmann, S., Drexler, HC., Itoh, N., Hirose, T., Breier, G., Vestweber, D., Cooper, JA., Ohno, S., Kaibuchi, K., and Adams, RH. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 15(3):249-260. (2013)

26. Wang, S., Watanabe, T., Matsuzawa, K., Katsumi, A., Kakeno, M., Matsui, T., Ye F.,Sato, K., Murase, K., Sugiyama,e I., Kimura, K., Mizoguchi, A., Matsuda, M., Ginsberg, MH., Collard, JG., and Kaibuchi, K. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J. Cell. Biol 199(2):331-345. (2012)

27. Kato, K., Yazawa, T., Taki, K., Mori, K., Wang, S., Nishioka, T., Hamaguchi, T., Itoh, T.,Takenawa, T., Kataoka, C., Matsuura, Y., Amano, M., Murohara, T., and Kaibuchi, K. The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. Mol Biol Cell 23(13):2593-2604. (2012)

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30. Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, MR., Tokumitsu, H., Soderling, TR., Sakakibara, A., Miyata, T., Kamiguchi, H., and Kaibuchi, K. Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca2+/Calmodulin-Dependent Protein Kinases. Science Signaling ra76. (2011)

31. Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Menager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, R. A., Fukuda, M., and Kaibuchi, K. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell 16 (5), 675-686. (2009)

32. Watanabe, T., Noritake, J., Kakeno, M., Matsui, T., Harada, T., Wang, S., Itoh, N., Sato, K., Matsuzawa, K., Iwamatsu, A., Galjart, N., and Kaibuchi, K. Phosphorylation of CLASP2 by GSK-3β regulates its interaction with IQGAP1, EB1 and microtubules. J Cell Sci 122(16):2969-2979. (2009)

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35. Taya, S., Shinoda, T., Tsuboi, D., Asaki, J., Nagai, K., Hikita, T., Kuroda, S., Kuroda, K., Shimizu, M., Hirotsune, S., Iwamatsu, A., and Kaibuchi, K. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci 27(1):15-26. (2007)

36. Shinoda, T., Taya, S., Tsuboi, D., Hikita, T., Matsuzawa, R., Kuroda, S., Iwamatsu, A., and Kaibuchi, K. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J Neurosci 27(1):4-14. (2007)

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39. Nishimura, T., Yamaguchi, T., Kato, K., Yoshizawa, M., Nabeshima, Y., Ohno, S., Hoshino, M., and Kaibuchi, K. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol 7(3):270-277. (2005)

40. Arimura, N., Ménager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., Morone, N., Usukura, J., and Kaibuchi, K. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol 25(22):9973-9984. (2005)

41. Watanabe, T., Wang, S., Noritake, J., Sato, K., Fukata, M., Takefuji, M., Nakagawa, M., Izumi, N., Akiyama, T., and Kaibuchi, K. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 7(6):871-883. (2004)

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44. Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F., and Kaibuchi, K. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109, 873-885. (2002)

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