- A LANA peptide inhibits tumor growth by inducing CHD4 protein cleavage and triggers cell death.
Cell Chemical Biology 31 (11) 1909-1925.e7. 2024
PMID: 39488208
Hiroki Miura, Wang Kang Hsin, Tomoki Inagaki, Frank Chuang, Michiko Shimoda, Chie Izumiya, Tadashi Watanabe, Ryan R Davis, Clifford G Tepper, Somayeh Komaki, Ken-ichi Nakajima, Ashish Kumar, Yoshihiro Izumiya.
Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation.
PLoS Pathogens 20 (2) e1011954. 2024
PMID: 38300891
Ken Sagou, Yoshitaka Sato, Yusuke Okuno, Takahiro Watanabe, Tomoki Inagaki, Yashiro Motooka, Shinya Toyokuni, Takayuki Murata, Hitoshi Kiyoi, Hiroshi Kimura.
Kaposi’s sarcoma-associated herpesvirus terminal repeat regulates inducible lytic gene promoters.
Journal of Virology 98 (2) e01386-23. 2024
PMID: 38240593
Yoshihiro Izumiya, Adhraa Algalil, Jonna M. Espera, Hiroki Miura, Chie Izumiya, Tomoki Inagaki, Ashish Kumar.
Kaposi’s sarcoma-associated herpesvirus (KSHV) LANA prevents KSHV episomes from degradation.
Journal of Virology 98 (2) e01268-23. 2024
PMID: 38240588
Ken-ichi Nakajima, Tomoki Inagaki, Jonna Magdallene Espera, Yoshihiro Izumiya.
KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming.
PLoS Pathogens 19 (11) e1011771. 2023
PMID: 37934757
Tomoki Inagaki, Kang Hsin Wang, Ashish Kumar, Chie Izumiya, Hiroki Miura, Somayeh Komaki, Ryan R Davis, Clifford G Tepper, Harutaka Katano, Michiko Shimoda, Yoshihiro Izumiya.
KSHV uses vIL6 to expand infected immunosuppressive macrophages.
PLoS Pathogens 19 (10) e1011703. 2023
PMID: 37883374
Michiko Shimoda, Tomoki Inagaki, Ryan R. Davis, Alexander Merleev, Clifford G. Tepper, Emanual Maverakis, Yoshihiro Izumiya
KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin.
Journal of Virology 96 (14) e00565-22. 2022
PMID: 35867573
Mel Campbell, Chanikarn Chantarasrivong, Yuichi Yanagihashi, Tomoki Inagaki, Ryan R. Davis, Kazushi Nakano, Ashish Kumar, Clifford G. Tepper, Yoshihiro Izumiya
Epstein–Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection.
Cell Communication and Signaling 20 (1) 95. 2022
PMID: 35729616
Yoshitaka Sato, Masahiro Yaguchi, Yusuke Okuno, Hanako Ishimaru, Ken Sagou, Somi Ozaki, Takeshi Suzuki, Tomoki Inagaki, Miki Umeda, Takahiro Watanabe, Masahiro Fujimuro, Takayuki Murata, Hiroshi Kimura
KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.
Cell Reports 39 (6) 110788. 2022
PMID: 35545047
Ashish Kumar, Yuanzhi Lyu, Yuichi Yanagihashi, Chanikarn Chantarasrivong, Vladimir Majerciak, Michelle Salemi, Kang-Hsin Wang, Tomoki Inagaki, Frank Chuang, Ryan R. Davis, Clifford G. Tepper, Kazushi Nakano, Chie Izumiya, Michiko Shimoda, Ken-ichi Nakajima, Alexander Merleev, Zhi-Ming Zheng, Mel Campbell, Yoshihiro Izumiya
- Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication.
Nature Cell Biology 24 (11) 1595-1605. 2022
PMID: 36253535, 36810578 (Erratum)
Junichi Tanaka, Hidenobu Senpuku, Miho Ogawa, Rika Yasuhara, Shintaro Ohnuma, Koki Takamatsu, Takashi Watanabe, Yo Mabuchi, Shiro Nakamura, Shoko Ishida, Tomohiko Sadaoka, Takashi Takaki, Tatsuo Shirota, Toshikazu Shimane, Tomio Inoue, Takayoshi Sakai, Munemasa Mori, Takashi Tuji, Ichiro Saito, Kenji Mishima
A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation.
mBio 13 (4) e01864-22. 2022
PMID: 35916400
Tomohiko Sadaoka (corresponding author), Daniel P Depledge, Labchan Rajbhandari, Judith Breuer, Arun Venkatesan, Jeffrey I Cohen
Mutagenesis of the Varicella-Zoster Virus Genome Demonstrates That VLT and VLT-ORF63 Proteins Are Dispensable for Lytic Infection.
Viruses 13 (11) 2289. 2021
PMID: 34835095
Shirley E Braspenning, Robert Jan Lebbink, Daniel P Depledge, Claudia M E Schapendonk, Laura A Anderson, Georges M G M Verjans, #Tomohiko Sadaoka, #Werner J D Ouwendijk (#corresponding authors)
- Nectin-1 is an entry mediator for VZV infection of human neurons.
Journal of Virology 95 (22) e01227-21. 2021
PMID: 34468169
Labchan Rajbhandari, Priya Shukla, Balaji Jagdish, Abby Mandalla, Qingxue Li, Hojae Lee, Gabsang Lee, Tomohiko Sadaoka, Jeffrey I Cohen, Arun Venkatesan
Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection.
Frontiers in Microbiology 11 575255. 2021
PMID: 33613459
Tomoki Inagaki, Yoshitaka Sato, Jumpei Ito, Mitsuaki Takaki, Yusuke Okuno, Masayoshi Yaguchi, Masud H M, Takahiro Watanabe, Kei Sato, Shingo Iwami, Takayuki Murata and Hiroshi Kimura
Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency.
Nature Communications 11 (1) 6324. 2020
PMID: 33303747
*Werner J D Ouwendijk, *Daniel P Depledge (*first authors), Labchan Rajbhandari, Tihana Lenac Rovis, Stipan Jonjic, Judith Breuer, Arun Venkatesan, Georges M G M Verjans, Tomohiko Sadaoka (corresponding author)
Decoding the Architecture of the Varicella-Zoster Virus Transcriptome.
mBio 11 (5) e01568-20. 2020
PMID: 33024035
Shirley E Braspenning, Tomohiko Sadaoka, Judith Breuer, Georges M G M Verjans, #Werner J D Ouwendijk, #Daniel P Depledge (#corresponding authors)
Epstein-Barr virus tegument protein BGLF2 suppresses type I IFN signaling to promote EBV reactivation.
Journal of Virology 94 (11) e00258-20. 2020
PMID: 32213613
XueQiao Liu, Tomohiko Sadaoka, Tammy Krogmann, Jeffrey I Cohen
Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen.
Nature Communications 10 (1) 754. 2019
PMID: 30765700
Daniel P Depledge, Kalanghad Puthankalam Srinivas, Tomohiko Sadaoka, Devin Bready, Yasuko Mori, Dimitris G Placantonakis, Ian Mohr, Angus C Wilson
S-like-phase cyclin-dependent kinases stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcription.
Journal of Virology 93 e01707-01718. 2019
PMID: 30700607
Yoshitaka Sato, Takahiro Watanabe, Chihiro Suzuki, Yuichi Abe, H M Abdullah Al Masud, Tomoki Inagaki, Masahiro Yoshida, Takeshi Suzuki, Fumi Goshima, Jun Adachi, Takeshi, Tomonaga, Takayuki Murata, Hiroshi Kimura
A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61.
Nature Communications 9 (1) 167. 2018
PMID: 29563516
*Daniel P Depledge, *Werner J D Ouwendijk, *Tomohiko Sadaoka (*first authors), Shirley E Braspenning, Yasuko Mori, Randall J Cohrs, #Georges M G M Verjans, #Judith Breuer (#corresponding authors)
Human embryonic stem cell derived neurons are highly permissive for varicella-zoster virus lytic infection.
Journal of Virology 92 (1) e01108-17. 2018
PMID: 29046461
Tomohiko Sadaoka, Cindi Schwartz, Labchan Rajbhandari, Arun Venkatesan, Jeffrey I Cohen
Role of the JNK pathway in varicella-zoster virus lytic infection and reactivation.
Journal of Virology 91 (17) p. e00640-17. 2017
PMID: 28637759
*Sravya Kurapati, *Tomohiko Sadaoka (*first authors), Labchan Rajbhandari, Balaji Jagdish, Priya Shukla, Yong Jun Kim, Gabsang Lee, Jeffrey I Cohen, Arun Venkatesan
In vitro system using human neurons demonstrates that varicella-zoster vaccine virus is impaired for reactivation, but not latency.
Proceedings of the National Academy of Sciences of the United States of America 113 (17) E2403-2412. 2016
PMID: 27078099
Tomohiko Sadaoka, Daniel P Depledge, Labchan Rajbhandari, Arun Venkatesan, Judith Breuer, Jeffrey I Cohen
Identification of a novel mutation in MAGT1 and progressive multifocal leucoencephalopathy in a 58-year-old man with XMEN disease.
Journal of Clinical Immunology 35 112-118. 2015
PMID: 25504528
Fatima Dhalla, Sarah Murray, Ross Sadler, Benjamin Chaigne-Delalande, Tomohiko Sadaoka, Elizabeth Soilleux, Gulbu Uzel, Joanne Miller, Graham Peter Collins, Christian Simon Ross Hatton, Malini Bhole, Berne Ferry, Helen M Chapel, Jeffrey I Cohen, Smita Y Patel
Characterization of the human herpesvirus 6A U23 gene.
Virology 450-451 98-105. 2014
PMID: 24503071
Mayuko Hayashi, Kento Yoshida, Huamin Tang, Tomohiko Sadaoka, Akiko Kawabata, Chyntia Jasriwan, Yasuko Mori
Varicella-zoster virus ORF49 functions in the efficient production of progeny virus through its interaction with essential tegument protein ORF44.
Journal of Virology 88 (1) 188-201. 2014
PMID: 24155375
Tomohiko Sadaoka, Satoshi Serada, Junko Kato, Mayuko Hayashi, Yasuyuki Gomi, Tetsuji Naka, Koichi Yamanishi, Yasuko Mori
Characterization of the varicella-zoster virus ORF50 gene, which encodes glycoprotein M.
Journal of Virology 84 (7) 3488-3502. 2010
PMID: 20106918
Tomohiko Sadaoka, Tatsuya Yanagi, Koichi Yamanishi, Yasuko Mori
Varicella-zoster virus ORF1 gene product is a tail-anchored membrane protein localized to plasma membrane and trans-Golgi network in infected cells.
Virology 337 (2) 289-295. 2008
PMID: 18570967
Tetsuo Koshizuka, Tomohiko Sadaoka, Hironori Yoshii, Koichi Yamanishi, Yasuko Mori
Varicella-zoster virus glycoprotein M homolog is glycosylated, expressed on the viral envelope, and functions in viral cell-to-cell spread.
Journal of Virology 82 (2) 795-804. 2008
PMID: 17977964
*Yoshiaki Yamagishi, *Tomohiko Sadaoka (*first authors), Hironori Yoshii, Pranee Somboonthum, Takayoshi Imazawa, Kazuhiro Nagaike, Keiichi Ozono, Koichi Yamanishi, Yasuko Mori
Deletion in open reading frame 49 of varicella-zoster virus reduces virus growth in human malignant melanoma cells but not in human embryonic fibroblasts.
Journal of Virology 81 (22) 12654-12665. 2007
PMID: 17855513
Tomohiko Sadaoka, Hironori Yoshii, Takayoshi Imazawa, Koichi Yamanishi, Yasuko Mori
Human herpesvirus 7 U47 gene products are glycoproteins expressed in virions and associate with glycoprotein H.
Journal of General Virology 87 501-508. 2006
PMID: 16476971
Tomohiko Sadaoka, Koichi Yamanishi, Yasuko Mori
Human herpes virus 6 envelope cholesterol is required for virus entry.
Journal of General Virology 87 277-285. 2006
PMID: 16432b
012
Honglan Huang, Yongmei Li, Tomohiko Sadaoka, Huamin Tang, Takahito Yamamoto, Koichi Yamanishi, Yasuko Mori
Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2 into tetrameric complexes expressed on the viral envelope.
Journal of Virology 78 (15) 7969-7983. 2004
PMID: 15254169
Pilailuk Akkapaiboon, Yasuko Mori, Tomohiko Sadaoka, Sayoko Yonemoto, Koichi Yamanishi
Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46.
Journal of Virology 78 (9) 4609-4616. 2004
PMID: 15078943
Yasuko Mori, Pilailuk Akkapaiboon, Sayoko Yonemoto, Masato Koike, Masaya Takemoto, Tomohiko Sadaoka, Yumi Sasamoto, Shozo Konishi, Koichi Yamanishi
