Department of Molecular Imaging, Clinical Collaboration Unit,
School of Medical Sciences, Fujita Health University

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Introduction

lecular imaging is a diagnostic imaging technique that provides a detailed picture of what is going on in the body at the molecular and cellular levels. While other imaging modalities such as X-rays, computed tomography (CT), and ultrasound provide images of body structures, molecular imaging allows us to see how the body functions and measure chemical and biological processes. Molecular imaging includes diagnostic imaging techniques such as MRI and nuclear medicine, which can help catch diseases in their early stages and pinpoint the exact location of tumors. In molecular imaging, our goal is to develop and evaluate these imaging methods, develop new diagnostic indices by image analysis, and clarify their relationship to prognosis.

Members

Faculty members

Radiological technology

• Takatsu, Y., Ueyama, T., Iwasaki, T. et al.
  Simulation of time–intensity curve based on k-space filling in breast dynamic contrast-enhanced three-dimensional magnetic resonance imaging.
  Radiol Phys Technol (2024). https://doi.org/10.1007/s12194-024-00793-y
• Shiiba, T., Watanabe, M.Stability of radiomic features from positron emission tomography images: a phantom study comparing advanced reconstruction algorithms and ordered subset expectation maximization. Phys Eng Sci Med (2024). https://doi.org/10.1007/s13246-024-01416-x

• Takatsu Y, Nakamura M, Suzuki Y, Miyati T. Dependence of apparent diffusion coefficient on slice position in magnetic resonance diffusion imaging. Magn Reson Imaging. 2023;99:41-47. doi:10.1016/j.mri.2023.01.009
• Naoya Kuga, Takuro Shiiba, Tatsuhiko Sato, Shintaro Hashimoto & Yasuyoshi Kuroiwa. Experimental and computational verifications of the dose calculation accuracy of PHITS for high-energy photon beam therapy, Journal of Nuclear Science and Technology, DOI: 10.1080/00223131.2023.2275737

• Takatsu Y, Nakamura M, Suzuki Y, Miyati T. Dependence of apparent diffusion coefficient on slice position in magnetic resonance diffusion imaging. Magn Reson Imaging. 2023;99:41-47. doi:10.1016/j.mri.2023.01.009
• Takatsu, Y., Yoshida, R., Yamatani, Y. et al. Can magnetic resonance imaging after cranioplasty using titanium mesh detect brain tumors?. Phys Eng Sci Med (2022). https://doi.org/10.1007/s13246-022-01200-9
• Yasuo Takatsu, Masafumi Nakamura, Hajime Sagawa, Yuichi Suzuki, Nobuyuki Mori, Shunichi Motegi, Tosiaki Miyati. Differences in apparent diffusion coefficients between normal brain echo- planar images and turbo spin-echo diffusion-weighted images with distortion correction. 149:110202, 2022.
• Yasuo Takatsu, Kenichirou Yamamura, Yuya Yamatani, Daisuke Takahashi, Rei Yoshida, Masaki Asahara, Michitaka Honda, Tosiaki Miyati. Echo‑planar imaging is superior to fast spin‑echo diffusion‑weighted imaging for cranioplasty using titanium mesh in brain magnetic resonance imaging: a phantom study. Radiological Physics and Technology (in press),
• Shiiba T, Sekikawa Y, Tateoka S, et al. Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom. EJNMMI Phys. 2022;9(1):48. Published 2022 Jul 30. doi:10.1186/s40658-022-00477-9
• Shiiba, T., Takano, K., Takaki, A. et al. Dopamine transporter single-photon emission computed tomography-derived radiomics signature for detecting Parkinson’s disease. EJNMMI Res 12, 39 (2022). https://doi.org/10.1186/s13550-022-00910-1

• Yasuo Takatsu, Masafumi Nakamura, Satoshi Kobayashi, Tosiaki Miyati.Prediction of sufficient liver enhancement in the gadoxetate disodium-enhanced hepatobiliary phase by transitional phase images and albumin–bilirubin grade. Magnetic Resonance in Medical Sciences, 20:152-159, 2021,
• Yasuo Takatsu, Tsuyoshi Ueyama, Takahiro Iwasaki, Masaki Asahara, Michitaka Honda, Tosiaki Miyati. Effects of k-space orders on the time-intensity curves in dynamic contrast-enhanced magnetic resonance imaging of the breast based on simulation study. Magnetic Resonance Imaging. 79:85-96, 2021,
• Yasuo Takatsu, Rei Yoshida, Kenichirou Yamamura, Yuya Yamatani, Tsuyoshi Ueyama, Tetsuya Kimura, Yuriko Nohara, Tomohiro Sahara, Kengo Nishiyama, Tosiaki Miyati. Three-dimensional gradient echo sequence is useful for suppressing the radiofrequency shielding effect of a titanium mesh. Magnetic Resonance in Medical Sciences, 20:182-189, 2021,
• Yasuo Takatsu, Masafumi Nakamura, Takanobu Yamashiro, Atsushi Ikemoto, Satoshi Sawa, Masanobu Nakamura, Tosiaki Miyati. Evaluation of contrast and denoising effects related to imaging parameters of compressed sensitivity encoding in contrast‑enhanced magnetic resonance imaging. Radiological Physics and Technology, 14:193-202, 2021,
• Yasuo Takatsu, Masafumi Nakamura, Toshiki Shiozaki, Shoko Narukami, Tosiaki Miyati, Satoshi Kobayashi. Assessment of the cut-off value of quantitative livereportal vein contrast ratio in the hepatobiliary phase of liver MRI. Clinical Radiology, 76:551.e17-551.e24, 2021,
• Eisuke Sato, Kei Fukuzawa, Hiroyuki Takashima, Yuya Yamatani, Yasuo Takatsu, Junichi Hata, Keigo Hikishima, Kenta Miwa. Evaluation of a polyethylene glycol phantom for measuring apparent diffusion coefficients using three 3.0 T MRI systems. Applied Magnetic Resonance, 52:619-631, 2021,

• Shiiba, T, Arimura, Y, Nagano M, Takahashi T, Takaki A. Improvement of classification performance of Parkinson's disease using shape features for machine learning on dopamine transporter single photon emission computed tomography. PLoS ONE, 15(1), e0228289, 2020.
• Takano K, Yamada M. Contrast-enhanced magnetic resonance imaging evidence for the role of astrocytic aquaporin-4 water channels in glymphatic influx and interstitial solute transport. Magnetic Resonance Imaging, 71,11–16, 2020.
• Yasuo Takatsu, Hajime Sagawa, Masafumi Nakamura, Yuichi Suzuki, Tosiaki Miyati. Diffusion-weighted breast magnetic resonance imaging with distortion correction using non-rigid image registration: A clinical study. Radiological Physics and Technology, 13:210–218, 2020,

1. Shirakawa, S., K. Tsukamoto, H. Azuma, K. Nakashima, M. Tsujimoto, K. Takano, and M. Yamada. Nonuniform sampling pitch acquisition method in myocardial single-photon emission computed tomography. Nuclear medicine communications, 40(8), 792–801, 2019.

1. Yamada M, Takano K, Kawai Y, Kato R. Hemodynamic-based Mapping of Neural Activity in Medetomidine-sedated Rats using a 1.5T Compact Magnetic Resonance Imaging System: A Preliminary Study. Magn Reson Med Sci. 2015;14(3): 243-250.

1. Umezawa E, Yoshikawa M, Ohno K, Yoshikawa E, Yamaguchi K. Multi-shelled q-ball imaging: moment-based orientation distribution function. Magnetic Resonance in Medical Sciences 2010;9(3):119-129. DOI: 10.2463/mrms.9.119

1. Umezawa E, Yoshikawa M, Yamaguchi K, Ueoku S, Tanaka E. qQ-Space space imaging using small magnetic field gradient. Magnetic Resonance in Medical Sciences 2006;5(4):179-189. DOI: 10.2463/mrms.5.179

1. Yasuo Taktsu. Contrast-Free Tumor Classification in Liver MRI. ICMRI2023, Nov. 3–4, Seoul, Korea.
2. Takuya Shimozono and Takuro Shiiba. Magnetic Resonance T1w/T2w Ratio-Based Radiomics Score for Predicting Clinical Motor Outcomes in Parkinson’s Disease. AAPM 65th Annual Meeting, July 23–27, Houston, TX, USA  
3. Takuro Shiiba. Does radiomics score obtained from dopamine transporter SPECT reflect the severity of Parkinson's disease? SNMMI2023, June 24–27, Chicago IL, USA

1. Yasuo Takatsu, Masafumi Nakamura, Hajime Sagawa, Yuichi Suzuki, Nobuyuki Mori, Shunichi Motegi, Tosiaki Miyati. New reference ADC data for the normal brain with distortion correction in TSE- and EPI-DWI. Joint Annual Meeting ISMRM-ESMEMB ISMRT31st Annual Meetig, 2022.05.07-12　London

2. Yasuo Takatsu, Rei Yoshida, Yuya Yamatani, Mikihisa Kanno, Tosiaki Miyati. Brain Tumor Detectability on the Radio Frequency-Shielding Effect; A Phantom Study. the 10th International Congress on MRI & 27th Annual Scientific Meeting of KSMRM (ICMRI 2022), 2022.11.04-05 Seoul.

1. Takuro Shiiba, Yuya Sekikawa, Takuro Shiiba, Shinji Tateoka, Nobutaka Shinohara, Yuuki Inoue, Yasuyoshi Kuroiwa, Yuya Sekikawa, Takashi Tanaka, Yasushi Kihara, Takuroh Imamura. Impact of SwiftScan technique on quantitative bone single photon emission computed tomography. Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021, June 11-15, 2021, WEB.
2. Yuya Sekikawa, Takuro Shiiba, Shinji Tateoka, Nobutaka Shinohara, Yuuki Inoue, Yasuyoshi Kuroiwa, Takashi Tanaka, Yasushi Kihara, Takuroh Imamura. The impact of acquisition time on quantitative bone single photon emission computed tomography using the SwiftScan technique. Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021, June 11-15, 2021, WEB.
3. Yasuo Takatsu, Masafumi Nakamura, Satoshi Kobayashi, Tosiaki MiyatiInvestigation of new assessment method for the liver magnetic resonance imaging. ISMRM & SMRT Virtual Conference & Exhibition. 2021.05.15-20 On line
4. Yasuo Takatsu, Kenichiro Yamamura, Yuya Yamatani, Daisuke Takahashi, Rei Yoshida, Masaki Asahara, Michitaka Honda, Tosiaki Miyati. Influence of Radiofrequency-Shielding Effect of a Titanium Mesh in Magnetic Resonance Diffusion-Weighted Imaging. the 9th International Congress on MRI & 26th Annual Scientific Meeting of KSMRM (ICMRI 2021) 2021.11.05-06 Seoul

1. Takuro Shiiba, Masahiro Harada, Kaito Ijima. Feasibility of Applying Super-Resolution Techniques Using Deep Learning to SPECT Images. European congress of radiology (ECR) 2021, March 3–7, 2021, WEB.
2. Takuro Shiiba, Akihiro Takaki. Feasibility of Improvement of Prediction Performance for Motor Function Prognosis in Parkinson‘s Disease Using Dopamine Transporter SPECT Image Features. 76th Japanese Society of Radiological Technology，May 23-June 17, 2020，WEB.
3. Yasuo Takatsu, Hajime Sagawa, Masafumi Nakamura, Yuichi Suzuki, Tosiaki Miyati. Effectiveness of distortion correction for diffusion-weighted imaging using clinical images. ISMRM & SMRT Virtual Conference & Exhibition, 2020.08.08-14　On line
4. Yasuo Takatsu, Rei Yoshida, Kinichiro Yamamura, Yuya Yamatani, Tosiaki Miyati. Useful sequence for suppressing the radiofrequency shielding effect of a titanium mesh. ISMRM & SMRT Virtual Conference & Exhibition, 2020.08.08-14　On line

1. Takuro Shiiba, Akihiro Takaki. Comparison of diagnostic performance of deep convolutional neural network using fine-tuning and feature extraction on dopamine transporter single photon emission tomography images. Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019, June 22–25,2019, Anaheim, CA, USA.
2. Takuro Shiiba, Yuka Nakamura, Taichi Nakamura, Akihiro Takaki. Development of classification method using automatic shape extraction for dopamine transporter SPECT image. 75th Japanese Society of Radiological Technology，April 11th–14, 2019，Yokohama.

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