Department of Preventive Medical Sciences,
Faculties of Medical Sciences, Fujita Health University

News & Topics

• 18 Jan 2024

• 12 May 2023

• 20 Apr 2020

• 4 Apr 2023

• 10 Apr 2022
　We have new members. (Mr.Okumiyama and Mr. Nakae, M1) 
• 25 Nov 2022

1.    Our research paper entitled “Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease” was published in Clinical Biochemistry. (here) 
2.    Dr. R Fujii's Editorial article entitled “Genetically instrumented public health: facing obesity to prevent chronic kidney disease” was published in Cardiovascular Research. (here) 

• 11 Oct 2022

• 8 Jun 2022

1.    Our research paper entitled “Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population” was published in Circulation: Genomic and Precision Medicine. (here) 
2.    Our research paper entitled “Increased risk of cancer mortality by smoking-induced aryl hydrocarbon receptor repressor DNA hypomethylation in Japanese population: A long-term cohort study” was published in Cancer Epidemiology. (here) 

• 10 Apr 2022

• 21 Dec 2021

• 30 Aug 2021

• 12 Aug 2021

• 22 Jun 2021

Introduction

In the Department of Preventive Medical Sciences, we conduct molecular epidemiological studies on the development of non-communicable diseases. For example, we are constructing risk model for disease onset using genetic information and analyzing biomarkers that mediate between exposure (life-style) and outcome (disease). Our goal is to contribute to preventive medicine by predicting the disease onset or elucidating the molecular mechanism.
If you are interested in Epidemiology, biomarker analysis, prevention of disease onset, and/or statistical analysis, welcome to visit our laboratory and join us.

Members

Faculty members

Medical Technology

• Japan Collaborative Cohort Study (JACC Study) here
• Research project for prospective Investigation of health problems Among Survivors of the Great East Japan Earthquake and Tsunami Disaster (RIAS Study) here

• Fujii R, Nakatochi M, Del Greco M F. Coffee Intake, Plasma Caffeine Levels, and Kidney Function: Two-Sample Mendelian Randomization Among East Asian and European Ancestries. Kidney Int Rep. 2024 Jan; in press.
• Mizuno G, Yamada H, Tsuboi Y, Munetsuna E, Yamazaki M, Ando Y, Kageyama I, Nouchi Y, Teshigawara A, Hattori Y, Fujii R, Ishikawa H, Hashimoto S, Ohashi K, Hamajima N, Suzuki K. Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan. J Nutr Health Aging. 2024 Jan;28(1):100013.
•  Sakaguchi E, Naruse H, Ishihara Y, Hattori H, Yamada A, Kawai H, Muramatsu T, Tsuboi Y, Fujii R, Suzuki K, Ishii J, Saito K, Sarai M, Yanase M, Ozaki Y, Izawa H. Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit. Sci Rep. 2024 Jan 2;14(1):75.
• Ando Y, Munetsuna E, Yamada H, Ikeya M, Teshigawara A, Kageyama I, Nouchi Y, Wakasugi T, Yamazaki M, Mizuno G, Tsuboi Y, Ishikawa H, Ohgami N, Suzuki K, Ohashi K. Impact of maternal fructose intake on liver stem/progenitor cells in offspring: Insights into developmental origins of health and disease. Life Sci. 2024 Jan 1;336:122315.

• Fujii R. Visualization of Relative Measures of Association: Points and Error Bars With an Appropriate Axis Scale. J Epidemiol. 2023 Sep 5;33(9):487-488.
• Funahashi H, Takegami Y, Osawa Y, Nakashima H, Ishizuka S, Fujii R, Yamada H, Suzuki K, Hasegawa Y, Imagama S. Circulating miRNA-122 is associated with knee osteoarthritis progression: A 6-year longitudinal cohort study in the Yakumo study. J Orthop Sci. 2023 Nov 7:S0949-2658(23)00276-2.
• Hattori Y, Yamada H, Munetsuna E, Fujii R, Ando Y, Yamazaki M, Mizuno G, Tsuboi Y, Ishihara Y, Ichino N, Sugimoto K, Osakabe K, Ishikawa H, Ohashi K, Suzuki K. The Ratio of miR-122 to miR-20a (miR-122/miR-20a) Is a Useful Minimally Invasive Biomarker for Non-Alcoholic Fatty Liver Disease Detection. Genet Test Mol Biomarkers. 2023 Aug;27(8):239-247.
• Mizuno G, Yamada H, Munetsuna E, Ando Y, Teshigawara A, Ito M, Kageyama I, Nouchi Y, Wakasugi T, Sakakibara T, Yamazaki M, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K. High-fructose corn syrup intake increases hepatic mitochondrial DNA copy number and methylation in adolescent rats. Nutr Res. 2023 Feb;110:57-65.
• Fujii R, Pattaro C, Tsuboi Y, Ishihara Y, Melotti R, Yamada H, Ando Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Barbieri G, Ghasemi-Semeskandeh D, Suzuki K. Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease. Clin Biochem. 2023 Jan;111:54-59.
...
他4報

• Fujii R, Pattaro C. Genetically-instrumented public health: facing obesity to prevent chronic kidney disease. Cardiovasc Res. 2022 Dec 9;118(15):3013-3015.
• Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Intake of vegetables and fruits rich in provitamin A is positively associated with aryl hydrocarbon receptor repressor DNA methylation in a Japanese population. Nutrition Res. 107:206-217. 2022
• Fujii R, Suzuki K, Yamada H, Kawado M, Hashimoto S, Tsuboi Y, Wakai K, Iso H, Watanabe Y, Fujino Y, Tamakoshi A; JACC Study Group. Association between serum carotenoids and premature mortality in a population-based case-control study. Nagoya J Med Sci. 84(3):607-620. 2022
• Suzuki K, Yamada H, Fujii R, Munetsuna E, Yamazaki M, Ando Y, Ohashi K, Ishikawa H, Mizuno G, Tsuboi Y, Hashimoto S, Hamajima N. Circulating microRNA-27a and -133a are negatively associated with incident hypertension: a five-year longitudinal population-based study. Biomarkers. 27(5):496-502. 2022
• Fujii R, Hishida A, Nakatochi M, Tsuboi Y, Suzuki K, Kondo T, Ikezaki H, Hara M, Okada R, Tamura T, Shimoshikiryo I, Suzuki S, Koyama T, Kuriki K, Takashima N, Arisawa K, Momozawa Y, Kubo M, Takeuchi K, Wakai K; J-MICC Study Group. Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. Circ Genom Precis Med. 15(4):e003612. 2022
• Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Increased risk of cancer mortality by smoking-induced aryl hydrocarbon receptor repressor DNA hypomethylation in Japanese population: A long-term cohort study. Cancer Epidemiol. 78:102162. 2022

• Ryosuke Fujii, Shuntaro Sato, Yoshiki Tsuboi, Andres Cardenas, Koji Suzuki. DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of causal mediation analysis. Epigenetics. 2021;1-27. doi: 10.1080/15592294.2021.1959736.
• Ryosuke Fujii, Hiroya Yamada, Yoshiki Tsuboi, Yoshitaka Ando, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Yuya Ishihara, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Association between circulating microRNAs and changes in kidney function: a five-year prospective study among Japanese adults without CKD. Clin Chim Acta. 201;521:97-103.
• Ryosuke Fujii, Yoshiki Tsuboi, Keisuke Maeda, Yuya Ishihara, Koji Suzuki. Analysis of Repeated Measurements of Serum Carotenoid Levels and All-Cause and Cause-Specific Mortality in Japan. JAMA Network Open. 2021;4:e2113369.
• Hiroya Yamada, Koji Suzuki, Ryosuke Fujii, Miyuki Kawado, Shuji Hashimoto, Yoshiyuki Watanabe, Hiroyasu Iso, Yoshihisa Fujino, Kenji Wakai, Akiko Tamakoshi, and the JACC Study Group.Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study. Sci Rep. 2021;11:5298.
• Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Global DNA hypermethylation in peripheral blood mononuclear cells and cardiovascular disease risk: a population-based propensity score-matched cohort study. J Epidemiol Community Health. 2021;75:890-895.
• Sadayuki Ito, Hiroaki Nakashima, Kei Ando, Kazuyoshi Kobayashi, Masaaki Machino, Taisuke Seki, Shinya Ishizuka, Ryosuke Fujii, Yasuhiko Takegami, Hiroya Yamada, Yoshitaka Ando, Koji Suzuki, Yukiharu Hasegawa, Shiro Imagama. Association between Low Muscle Mass and Inflammatory Cytokines. Biomed Res Int. 2021;2021:5572742.
• Koji Suzuki, Hiroya Yamada, Ryosuke Fujii, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Mirai Yamazaki, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima. Association between circulating vascular-related microRNAs and an increase in blood pressure: A five-year longitudinal population-based study. Journal of Hypertension. 2021;39:84-89.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Chiharu Hagiwara, Kenji Wakai, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Dietary fish and n-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels. Nutrition. 2021;81:110951.

…
Eight other reports

• Keisuke Maeda, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population. PloS One 2020;15:e0235486.
• Koji Suzuki, Nitin Shivappa, Miyuki Kawado, Hiroya Yamada, Shuji Hashimoto, Kenji Wakai, Hiroyasu Iso, Emiko Okada, Ryosuke Fujii, James R. Hébert, Akiko Tamakoshi. Association between dietary inflammatory index and serum C-reactive protein 1 concentrations in the Japan Collaborative Cohort Study. Nagoya J Med Sci. 2020;82:237–249.
• Mirai Yamazaki, Eiji Munetsuna, Hiroya Yamada, Yoshitaka Ando, Genki Mizuno, Ryosuke Fujii, Hiroaki Ishikawa, Koji Suzuki, Yohei Shimono, Shuji Hashimoto, Koji Ohashi. Maternal fructose consumption downregulates Lxra expression via miR-206-mediated regulation. J Nutr Biochem. 2020; 82:108386.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Keisuke Maeda, Chiharu Hagiwara, Yoshitaka Ando, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Associations of circulating microRNAs (miR-17, miR-21, and miR-150) and chronic kidney disease in a Japanese population. J Epidemiol. 2020;30:177-182.

• Ryosuke Fujii, Hiroya Yamada, Mirai Yamazaki, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Haruki Shimoda, Kiyomi Sakata, Akira Ogawa, Seiichiro Kobayashi, Koji Suzuki. Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake. BMC Nephrol. 2019;20:474.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Chiharu Hagiwara, Keisuke Maeda, Shuji Hashimoto, Koji Suzuki. Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population. Am J Clin Nutr. 2019;110:1213-1219.
• Ryosuke Fujii, Asahi Hishida, Koji Suzuki, Nahomi Imaeda, Chiho Goto, Nobuyuki Hamajima, Kenji Wakai, Takaaki Kondo. CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population. Br J Nutr. 2019;121:1215-1222.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Yoshitaka Ando, Chiharu Hagiwara, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women. Nutrition. 2019;65:1-5.
• Mari Kondo, Hiroya Yamada, Munetsuna Eiji, Mirai Yamazaki, Takeshi Hatta, Akihiko Iwahara, Koji Ohashi, Hiroaki Ishikawa, Yoshiki Tsuboi, Takashi Inoue, Ryosuke Fujii, Koji Suzuki. Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: the Yakumo Study. Arch Gerontol Geriatr. 2019;82:155-160.

• Yoshiki Tsuboi　The 80th Annual Meeting of Japanese Society of Public Health (Dec, 2021), Excellent Presentation Award
• Ryosuke Fujii　The 91st Annual Meeting of the Japanese Society for Hygiene (Mar, 2021), Young Excellent Presentation Award
• Koji Suzuki　The 30th Annual Meeting of the Japan Epidemiological Association (Feb, 2020), Epidemiology seminar (Presenter)
• Keisuke Maeda　The 78th Annual Meeting of Japanese Society of Public Health (Oct, 2019), Excellent Poster Award

• 藤井亮輔，鈴木康司著「超入門！　Rでできるビジュアル統計学　学会・論文発表に役立つデータ可視化マニュアル」（金芳堂），2021年10月（LINK）
• 藤井亮輔，鈴木康司著「超入門！　Rでできるビジュアル統計学　解析編　学会・論文発表に役立つデータ可視化マニュアル」（金芳堂），2023年4月（LINK）

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