医療科学部 研究推進ユニット
医療検査学科 予防医科学分野

ニュース&トピックス

• 2024年3月7日-9日

• 2024年1月31日-2月1日

• 2024年1月18日

分野紹介

予防医科学分野では、ヒト集団を対象にした生活習慣病発症に関わる分子疫学研究をおこなっています。例えば、遺伝子情報を活用した疾病発症リスクモデルの構築や、原因（生活習慣）と結果（疾患）の間に介在する生体内のバイオマーカーの分析を行っています。そして、各種疾病の発症リスク予測および発症メカニズム解明に寄与し予防医学への貢献を目指します。
“疾病の発症予防”、”バイオマーカー分析”、”疫学研究”、”統計解析”などに興味のある方お待ちしてます。

メンバー

教員

医療検査学科

• 多施設共同コホート研究（JACC Study）こちら
• 岩手県における東日本大震災被災者の支援を目的とした大規模コホート研究（RIAS Study）こちら

• Fujii R, Nakatochi M, Del Greco M F. Coffee Intake, Plasma Caffeine Levels, and Kidney Function: Two-Sample Mendelian Randomization Among East Asian and European Ancestries. Kidney Int Rep. 2024 Jan; in press.
• Mizuno G, Yamada H, Tsuboi Y, Munetsuna E, Yamazaki M, Ando Y, Kageyama I, Nouchi Y, Teshigawara A, Hattori Y, Fujii R, Ishikawa H, Hashimoto S, Ohashi K, Hamajima N, Suzuki K. Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan. J Nutr Health Aging. 2024 Jan;28(1):100013.
•  Sakaguchi E, Naruse H, Ishihara Y, Hattori H, Yamada A, Kawai H, Muramatsu T, Tsuboi Y, Fujii R, Suzuki K, Ishii J, Saito K, Sarai M, Yanase M, Ozaki Y, Izawa H. Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit. Sci Rep. 2024 Jan 2;14(1):75.
• Ando Y, Munetsuna E, Yamada H, Ikeya M, Teshigawara A, Kageyama I, Nouchi Y, Wakasugi T, Yamazaki M, Mizuno G, Tsuboi Y, Ishikawa H, Ohgami N, Suzuki K, Ohashi K. Impact of maternal fructose intake on liver stem/progenitor cells in offspring: Insights into developmental origins of health and disease. Life Sci. 2024 Jan 1;336:122315.

• Fujii R. Visualization of Relative Measures of Association: Points and Error Bars With an Appropriate Axis Scale. J Epidemiol. 2023 Sep 5;33(9):487-488.
• Funahashi H, Takegami Y, Osawa Y, Nakashima H, Ishizuka S, Fujii R, Yamada H, Suzuki K, Hasegawa Y, Imagama S. Circulating miRNA-122 is associated with knee osteoarthritis progression: A 6-year longitudinal cohort study in the Yakumo study. J Orthop Sci. 2023 Nov 7:S0949-2658(23)00276-2.
• Hattori Y, Yamada H, Munetsuna E, Fujii R, Ando Y, Yamazaki M, Mizuno G, Tsuboi Y, Ishihara Y, Ichino N, Sugimoto K, Osakabe K, Ishikawa H, Ohashi K, Suzuki K. The Ratio of miR-122 to miR-20a (miR-122/miR-20a) Is a Useful Minimally Invasive Biomarker for Non-Alcoholic Fatty Liver Disease Detection. Genet Test Mol Biomarkers. 2023 Aug;27(8):239-247.
• Mizuno G, Yamada H, Munetsuna E, Ando Y, Teshigawara A, Ito M, Kageyama I, Nouchi Y, Wakasugi T, Sakakibara T, Yamazaki M, Ishikawa H, Suzuki K, Hashimoto S, Ohashi K. High-fructose corn syrup intake increases hepatic mitochondrial DNA copy number and methylation in adolescent rats. Nutr Res. 2023 Feb;110:57-65.
• Fujii R, Pattaro C, Tsuboi Y, Ishihara Y, Melotti R, Yamada H, Ando Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Barbieri G, Ghasemi-Semeskandeh D, Suzuki K. Comparison of glomerular filtration rate estimating formulas among Japanese adults without kidney disease. Clin Biochem. 2023 Jan;111:54-59.

• Fujii R, Pattaro C. Genetically-instrumented public health: facing obesity to prevent chronic kidney disease. Cardiovasc Res. 2022 Dec 9;118(15):3013-3015.
• Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Intake of vegetables and fruits rich in provitamin A is positively associated with aryl hydrocarbon receptor repressor DNA methylation in a Japanese population. Nutrition Res. 107:206-217. 2022
• Fujii R, Suzuki K, Yamada H, Kawado M, Hashimoto S, Tsuboi Y, Wakai K, Iso H, Watanabe Y, Fujino Y, Tamakoshi A; JACC Study Group. Association between serum carotenoids and premature mortality in a population-based case-control study. Nagoya J Med Sci. 84(3):607-620. 2022
• Suzuki K, Yamada H, Fujii R, Munetsuna E, Yamazaki M, Ando Y, Ohashi K, Ishikawa H, Mizuno G, Tsuboi Y, Hashimoto S, Hamajima N. Circulating microRNA-27a and -133a are negatively associated with incident hypertension: a five-year longitudinal population-based study. Biomarkers. 27(5):496-502. 2022
• Fujii R, Hishida A, Nakatochi M, Tsuboi Y, Suzuki K, Kondo T, Ikezaki H, Hara M, Okada R, Tamura T, Shimoshikiryo I, Suzuki S, Koyama T, Kuriki K, Takashima N, Arisawa K, Momozawa Y, Kubo M, Takeuchi K, Wakai K; J-MICC Study Group. Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population. Circ Genom Precis Med. 15(4):e003612. 2022
• Tsuboi Y, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Hattori Y, Ishikawa H, Ohashi K, Hashimoto S, Hamajima N, Suzuki K. Increased risk of cancer mortality by smoking-induced aryl hydrocarbon receptor repressor DNA hypomethylation in Japanese population: A long-term cohort study. Cancer Epidemiol. 78:102162. 2022

• Ryosuke Fujii, Shuntaro Sato, Yoshiki Tsuboi, Andres Cardenas, Koji Suzuki. DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of causal mediation analysis. Epigenetics. 2021;1-27. doi: 10.1080/15592294.2021.1959736.
• Ryosuke Fujii, Hiroya Yamada, Yoshiki Tsuboi, Yoshitaka Ando, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Yuya Ishihara, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Association between circulating microRNAs and changes in kidney function: a five-year prospective study among Japanese adults without CKD. Clin Chim Acta. 201;521:97-103.
• Ryosuke Fujii, Yoshiki Tsuboi, Keisuke Maeda, Yuya Ishihara, Koji Suzuki. Analysis of Repeated Measurements of Serum Carotenoid Levels and All-Cause and Cause-Specific Mortality in Japan. JAMA Network Open. 2021;4:e2113369.
• Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Global DNA hypermethylation in peripheral blood mononuclear cells and cardiovascular disease risk: a population-based propensity score-matched cohort study. J Epidemiol Community Health. 2021;75:890-895.
• Koji Suzuki, Hiroya Yamada, Ryosuke Fujii, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Mirai Yamazaki, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima. Association between circulating vascular-related microRNAs and an increase in blood pressure: A five-year longitudinal population-based study. Journal of Hypertension. 2021;39:84-89.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yoshitaka Ando, Keisuke Maeda, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Chiharu Hagiwara, Kenji Wakai, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Dietary fish and n-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels. Nutrition. 2021;81:110951.

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他10報

• Keisuke Maeda, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population. PloS One 2020;15:e0235486.
• Koji Suzuki, Nitin Shivappa, Miyuki Kawado, Hiroya Yamada, Shuji Hashimoto, Kenji Wakai, Hiroyasu Iso, Emiko Okada, Ryosuke Fujii, James R. Hébert, Akiko Tamakoshi. Association between dietary inflammatory index and serum C-reactive protein 1 concentrations in the Japan Collaborative Cohort Study. Nagoya J Med Sci. 2020;82:237–249.
• Mirai Yamazaki, Eiji Munetsuna, Hiroya Yamada, Yoshitaka Ando, Genki Mizuno, Ryosuke Fujii, Hiroaki Ishikawa, Koji Suzuki, Yohei Shimono, Shuji Hashimoto, Koji Ohashi. Maternal fructose consumption downregulates Lxra expression via miR-206-mediated regulation. J Nutr Biochem. 2020; 82:108386.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Koji Ohashi, Hiroaki Ishikawa, Keisuke Maeda, Chiharu Hagiwara, Yoshitaka Ando, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Associations of circulating microRNAs (miR-17, miR-21, and miR-150) and chronic kidney disease in a Japanese population. J Epidemiol. 2020;30:177-182.

• Ryosuke Fujii, Hiroya Yamada, Mirai Yamazaki, Eiji Munetsuna, Yoshitaka Ando, Koji Ohashi, Hiroaki Ishikawa, Haruki Shimoda, Kiyomi Sakata, Akira Ogawa, Seiichiro Kobayashi, Koji Suzuki. Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake. BMC Nephrol. 2019;20:474.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Chiharu Hagiwara, Keisuke Maeda, Shuji Hashimoto, Koji Suzuki. Associations between dietary vitamin intake, ABCA1 gene promoter DNA methylation, and lipid profiles in a Japanese population. Am J Clin Nutr. 2019;110:1213-1219.
• Ryosuke Fujii, Asahi Hishida, Koji Suzuki, Nahomi Imaeda, Chiho Goto, Nobuyuki Hamajima, Kenji Wakai, Takaaki Kondo. CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population. Br J Nutr. 2019;121:1215-1222.
• Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yoshiki Tsuboi, Koji Ohashi, Hiroaki Ishikawa, Yoshitaka Ando, Chiharu Hagiwara, Keisuke Maeda, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki. Dietary vegetable intake is inversely associated with ATP-binding cassette protein A1 (ABCA1) DNA methylation levels among Japanese women. Nutrition. 2019;65:1-5.
• Mari Kondo, Hiroya Yamada, Munetsuna Eiji, Mirai Yamazaki, Takeshi Hatta, Akihiko Iwahara, Koji Ohashi, Hiroaki Ishikawa, Yoshiki Tsuboi, Takashi Inoue, Ryosuke Fujii, Koji Suzuki. Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: the Yakumo Study. Arch Gerontol Geriatr. 2019;82:155-160.

• 坪井良樹　第80回日本公衆衛生学会総会（2021年12月）優秀演題賞　「AHRR遺伝子のDNAメチル化率と死亡リスクとの関連を調査した縦断研究-Yakumo study-」
• 藤井亮輔　第91回日本衛生学会学術総会（2021年3月）若手優秀演題賞　「血清カロテノイドの反復測定値と死亡との関連：時間依存性Cox比例ハザードモデル」
• 鈴木康司　第30回日本疫学会学術総会（2020年2月）疫学セミナー「多施設共同コホート研究の運営と成果発表：JACC Studyの経験に学ぶ」
• 前田圭介　第78回日本公衆衛生学会総会（2019年10月）優秀ポスター賞　「住民健診受診者における喫煙習慣と白血球中TXNIP遺伝子のDNAメチル化率との関連」

• 藤井亮輔，鈴木康司著「超入門！　Rでできるビジュアル統計学　学会・論文発表に役立つデータ可視化マニュアル」（金芳堂），2021年10月（LINK）
• 藤井亮輔，坪井良樹著「超入門！　Rでできるビジュアル統計学　解析編　学会・論文発表に役立つデータ可視化マニュアル」（金芳堂），2023年4月（LINK）

• 藤田医科大学までのアクセス ⇒ 藤田学園ホームページ

• 予防医科学分野へのアクセス ⇒ 大学3号館2階216