Research of Clinical Pathophysiology
Faculty of Medical Sciences, Fujita Health University

Introduction

We aim to elucidate the pathophysiology of various diseases by utilizing imaging data and blood or urine samples provided by patients, and to apply the results to clinical practice. We are conducting a lot of clinical research in collaboration with the departments of pediatrics, cardiology and clinical laboratory.

Members

Faculty members

Medical Technology

Graduate student

Master’s course: Ami Suzuki (M1)

Research Theme

Research on Acute Kidney Injury (AKI) in Patients Treated at Medical Cardiac Intensive Care Units

Brain tumors have many histological types in the WHO classification, and it is not uncommon for histopathological diagnosis to be complicated. In addition, malignant brain tumors such as glioblastoma are difficult to remove by surgery, are resistant to radiochemotherapy, and often have a poor prognosis. Analyzing brain tumors' growth potential, drug resistance, and genetic alteration will provide beneficial information indispensable for treating patients. For these analyzes, we are carrying out the following studies, mainly using immunohistochemical techniques.
  • Early Detection of AKI

    Incidence of AKI when combining
    L-FABP and NT-proBNP tertiles.
    (Naruse H et al. Crit Care. 2018 22(1):197)

  • Prognostic Values of AKI

    Kaplan–Meier curves for the primary endpoint according to L-FABP increment (≥9 ng/mL) or serum creatinine-defined AKI status.
    (Naruse H et al. J. Clin. Med. 2020, 9, 482)

Risk Stratification using Biomarkers for Heart Failure

Combined assessment of D-Dimer with GWTG-HF Risk Score and NT-proBNP in all populations, HFpEF patients, and HFrEF patients. (Naruse H et al. J. Clin. Med. 2021, 10, 3564)

Risk Stratification using Biomarkers for Coronary Artery Disease

All-cause (A) and cardiovascular mortality rates (B) according to combination of D-dimer tertile and chronic kidney disease.
(Naruse H et al. Circ J 2017; 81: 1506–1513)

Research on Heart Disease and COVID-19

Academic Activities

Manuscripts

2021

  • Naruse H, Ishii J, Takahashi H, Kitagawa F, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Fujiwara W, Hayashi M, Motoyama S, Sarai M, Watanabe E, Izawa H, Ozaki Y. Urinary Liver-Type Fatty-Acid-Binding Protein Predicts Long-Term Adverse Outcomes in Medical Cardiac Intensive Care Units. J Clin Med. 2020 Feb 10;9(2):482.
  • Kawai H, Sarai M, Kato Y, Naruse H, Watanabe A, Matsuyama T, Takahashi H, Motoyama S, Ishii J, Morimoto SI, Toyama H, Ozaki Y. Diagnosis of isolated cardiac sarcoidosis based on new guidelines. ESC Heart Fail. 2020 Oct;7(5):2662-2671.
  • Miyajima K, Motoyama S, Sarai M, Kawai H, Nagahara Y, Matsumoto R, Fujiwara W, Muramatsu T, Takahashi H, Naruse H, Ishii J, Kondo T, Narula J, Izawa H, Ozaki Y. On-site assessment of computed tomography-derived fractional flow reserve in comparison with myocardial perfusion imaging and invasive fractional flow reserve. Heart Vessels. 2020 Oct;35(10):1331-1340.
  • Kusuki H , Tsuchiya Y, Mizutani Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Kojima A, Uchida H, Kojima N, Saito K, Sadanaga T, Hata T.
    QT Variability Index is Correlated with Autonomic Nerve Activity in Healthy Children.
    Pediatric Cardiology. 2020 Oct;41(7):1432-1437.
  • Hirono K, Miyao N, Yoshinaga M, Nishihara E, Yasuda K, Tateno S, Ayusawa M, Sumitomo N, Horigome H, Iwamoto M, Takahashi H, Sato S, Kogaki S, Ohno S, Hata T, Hazeki D, Izumida N, Nagashima M, Ohta K, Tauchi N, Ushinohama H, Doi S, Ichida F; Study group on childhood cardiomyopathy in Japan. A significance of school screening electrocardiogram in the patients with ventricular noncompaction.
    Heart Vessels. 2020 Jul;35(7):985-995
  • Suzuki T, Michihata T, Yoshikawa T, Hata T, Matsui H, Fushimi K, Yasunaga H. High-dose versus low-dose intravenous immunoglobulin for treatment of children with Kawasaki disease weighing 25 kg or more. Eur J Pediatr. 2020 Dec;179(12):1901-1907.
  • Fujigaki H, Takemura M, Osawa M, Sakurai A, Nakamoto K, Seto K, Fujita T, Hata T, Akiyama H, Doi Y, Saito K. Reliability of serological tests for COVID-19: comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. Heliyon. 2020 Sep 10;6(9):e04929.

2020

  • Shigeo Ohba, MD, PhD, Kazuhiro Murayama, MD, PhD, Kiyonori Kuwahara, MD, Eriel Sandika Pareira, MD, Shunsuke Nakae, MD, PhD, Yuya Nishiyama, MD, PhD, Kazuhide Adachi, MD, PhD, Seiji Yamada, MD, PhD, Hikaru Sasaki, MD, PhD, Naoki Yamamoto, MD, PhD, Masato Abe, MD, PhD, Joydeep Mukherjee, PhD, Mitsuhiro Hasegawa, MD, PhD, Russell O Pieper, PhD, Yuichi Hirose, MD, PhD, The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas, Neurosurgery, Volume 87, Issue 2, August 2020, Pages 408–417, https://doi.org/10.1093/neuros/nyz524
  • Takahashi, Y., Tsutsumi, Y., Takeuchi, C., Shiogama, K., Mizutani, Y., Inada, K. I., Yamamichi, N., & Koike, K. (2020). Nuclear staining of claudin-18 is a new immunohistochemical marker for diagnosing intramucosal well-differentiated gastric adenocarcinoma. Pathology international, 70(9), 644–652. https://doi.org/10.1111/pin.12978
  • Hiramatsu, N., Yamamoto, N., Isogai, S., Onouchi, T., Hirayama, M., Maeda, S., Ina, T., Kondo, M., & Imaizumi, K. (2020). An analysis of monocytes and dendritic cells differentiated from human peripheral blood monocyte-derived induced pluripotent stem cells. Medical molecular morphology, 53(2), 63–72. https://doi.org/10.1007/s00795-019-00231-8

2019

  • Naruse H, Takahashi H, Ishii J. Authors' response to letter "Prediction of acute kidney injury in intensive care unit patients". Crit Care. 2019 Feb 19;23(1):58.
  • Ishikawa M, Muramatsu T, Nanasato M, Nagasaka R, Takatsu H, Yoshiki Y, Hashimoto Y, Ohota M, Okumura M, Naruse H, Ishii J, Ito K, Takahashi H, Kamiya H, Yoshida Y, Ozaki Y. Associations of coronary plaque characteristics by integrated backscatter intravascular ultrasound with detectability of vessel external elastic lamina using optical frequency domain imaging in human coronary arteries: A sub-analysis of the MISTIC-1 trial. Catheter Cardiovasc Interv. 2019 Dec 1;94(7):947-955.

Conference

2021

  • Naruse H, Ishii J, Nishimura H, Ohta M, Sakaguchi E, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M, Tanizawa S, Sarai M, Watanabe E, Ozaki Y, Izawa H. Prognostic Value of Combination of Urinary Liver-Type Fatty Acid-Binding Protein and Plasma B-Type Natriuretic Peptide for Predicting Long-Term Adverse Outcomes. Annual Scientific Meeting of the Japanese Circulation Society 2021.
  • Naruse H, Ishii J, Nishimura H, Ohta M, Sakaguchi E, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M, Tanizawa S, Sarai M, Watanabe E, Ozaki Y, Izawa H. Combination of GWTG-HF Risk Score with D-Dimer and NT-proBNP in Patients Hospitalized for Worsening Heart Failure with Preserved Ejection Fraction. Annual Scientific Meeting of the Japanese Circulation Society 2021.

2020

  • Naruse H, Ishii J, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Watanabe E, Ozaki Y, Izawa H. Combined Assessment of American Heart Association Get With the Guidelines–Heart Failure Risk Score with Plasma D-Dimer and N-Terminal Pro-B-Type Natriuretic Peptide Levels Improves Prediction of Mortality in Patients Hospitalized for Worsening Heart Failure. AHA 2020.
  • Naruse H, Ishii J, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Watanabe E, Ozaki Y, Izawa H. Combined Assessment of GWTG-HF Risk Score and Plasma D-Dimer Levels in Patients Hospitalized for Heart Failure with Preserved Ejection Fraction. Annual Scientific Meeting of the Japanese Heart Failure Society 2020.

2019

  • Naruse H, Ishii J, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Watanabe E, Izawa H, Ozaki Y. Combined Assessment of Urinary Liver-type Fatty-acid Binding Protein and Plasma B-type Natriuretic Peptide Improves Prediction of Long-term Outcomes in Patients Treated at Medical Cardiac Intensive Care Units.AHA2019, Philadelphia, U.S.A., 2019.
  • Nishimura H, Ishii J, Takahashi H, Kitagawa F, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M,Tanizawa A, Naruse H, Sarai M, Watanabe E, Izawa H, Ozaki Y. Urinary Liver-Type Fatty Acid-Binding Protein is More Useful Than Neutrophil Gelatinase-Associated Lipocalin for Predicting Acute Kidney Injury. AHA2019, Philadelphia, U.S.A., 2019.
  • Ishii J, Kashiwabara K, Takahashi H, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M, Naruse H, Motoyama S, Sarai M, Watanabe E, Matsuyama Y, Izawa H, Ozaki Y, Nagai R. Circulating Levels of Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Event Risk in Patients With Stable Coronary Artery Disease Treated With High- versus Low-Dose Pitavastatin in the Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy With Pitavastatin in Coronary Artery Disease Trial AHA2019, Philadelphia, U.S.A., 2019.

Access

  • Access to regulatory science 206, 2nd  ⇒ University Building 3