医療科学部　臨床教育連携ユニット
臨床病態解析学分野

ニュース&トピックス

• 2024年3月10日

• 2024年3月9日

• 2023年11月17日

• 2023年6月12日

• 2023年4月9日

• 2023年3月12日

• 2023年3月10・11日

• 2023年1月20日

• 2022年6月13日

• 2022年4月1日

• 2022年3月13日

• 2021年8月18日

• 2021年8月1日

• 2021年6月14日

• 2021年4月1日

分野紹介

臨床病態解析学分野では、患者様からご提供頂いた画像データや検体(試料)を活用し、さまざまな疾患の病態解明を行い、その成果を臨床に応用することを目標にしています。小児科、循環器内科および臨床検査科などさまざまな診療科と連携して研究を進めています。

修士課程：下前 幸輝（M2）、上原 孔明（M2）、伊藤　将希(M1)

• Kawai H, Naruse H , Sarai M, Kato Y, Sato Y, Takahashi H, Ishii J, Ito H, Morimoto S,Izawa H. Serum angiotensin-converting enzyme levels indicating early sarcoidosis diagnosis and immunosuppressive therapy efficacy. ESC Heart Fail. 2023 Mar 9. 
• Sakaguchi E, Yamada A, Naruse H, Hattori H, Nishimura H, Kawai H, Muramatsu T, Ishii J, Hata T, Saito K, Izawa H. Long-term prognostic value of changes in left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction. Heart Vessels. 2023 May;38(5):645-652.

•  Yamabe S, Yamada A, Kawada Y, Ueda S, Hoshino N, Hoshino M, Takada K, Sakaguchi E, Ito R, Kakuno M, Sakakibara T, Ohshima S, Sarai M, Izawa H. Association of resting left ventricular global longitudinal strain with myocardial perfusion abnormalities evaluated by 13 N-ammonia positron emission tomography in patients with stable angina pectoris and normal left ventricular ejection fraction. Echocardiography. 2022 Dec;39(12):1555-1562.
• Ishii J, Kashiwabara K, Ozaki Y, Takahashi H, Kitagawa F, Nisihimura H, Ishii H, Iimuro S, Kawai H, Muramatsu T, Naruse H, Iwata H, Tanizawa-Motoyama S, Ito H, Watanabe E, Matsuyama Y, Fukumoto Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Hokimoto S, Miyauchi K, Ohtsu H, Izawa H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Matsuzaki M, Nagai R. Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Risk in Statin-Treated Patients with Coronary Artery Disease. J Atheroscler Thromb. 2022 Oct 1;29(10):1458-1474.
• Fujigaki H, Yamamoto Y, Koseki T, Banno S, Ando T, Ito H, Fujita T, Naruse H, Hata T, Moriyama S, Takahashi Y, Suzuki T, Murakami T, Yoshida Y, Yagura Y, Oyamada T, Takemura M, Kondo M, Iwata M, Saito K. Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2. Microbiol Spectr. 2022 Feb 23;10(1):e0118121

• Naruse H, Ishii J, Takahashi H, Kitagawa F, Sakaguchi E, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Fujiwara W, Hayashi M, Motoyama S, Sarai M, Watanabe E, Ito H, Ozaki Y, Izawa H. Combined Assessment of D-Dimer with Get With the Guidelines–Heart Failure Risk Score and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Acute Decompensated Heart Failure with Preserved and Reduced Ejection Fraction. J. Clin. Med. 2021, 10, 3564.
• Kawai H, Motoyama S, Sarai M, Nagahara Y, Hattori K, Sato Y, Miyajima K, Hoshino M, Matsuyama T, Ohta M, Takahashi H, Shiino K, Sugiura A, Muramatsu T, Naruse H, Ishii J, Toyama H, Ozaki Y, Izawa H. Association of computed tomography-derived myocardial mass with fractional flow reserve-verified ischemia or subsequent therapeutic strategy. Heart Vessels. 2021 Aug;36(8):1099-1108.
• Kusuki H , Mizutani Y, Tsuchiya Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Hosoi M, Matsuura H, Sadanaga T, Hata T. Myocardial repolarization time, J-point to T-peak and T-peak to T-end intervals, have different heart rate dependency and autonomic nerve interference in healthy prepubertal children. J Electrocardiol. Jul-Aug 2021;67:119-123
• Imamura T, Sumitomo N, Muraji S, Yasuda K, Nishihara E, Iwamoto M, Hata T, Horigome H,Ohno S, Ichida F, Nagashima M, Makiyama T, Yoshinaga M. Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children. Int J Cardiol. 2021 Jan 15;323:168-174.
• Muraji S, Sumitomo N, Imamura T, Yasuda K, Nishihara E, Iwamoto M, Tateno S, Doi S, Hata T, Kogaki S, Horigome H, Ohno S, Ichida F, Nagashima M, Yoshinaga M, Nakano S. Diagnostic value of P-waves in children with idiopathic restrictive cardiomyopathy. Heart Vessels. 2021 Aug;36(8):1141-1150.
• Kato A, Sato J, Yoshii K, Yoshida S, Nishikawa H, Ohashi N, Sakurai H, Hata T, Yoshikawa T. The mid-term outcome of Fontan conversion compared with primary total cavopulmonary connection. J Cardiol. 2021 Sep;78(3):213-218.
• Naruse H, Ito H, Izawa H,Sarai M, Ishii J, Sakaguchi E, Murakami R, Ando T, Fujigaki H, Saito K. Immunogenicity of BNT162b2 mRNA COVID-19 Vaccine in Patients with Cardiovascular Disease. J Clin Med. 2021 Nov 24;10(23):5498.

• Naruse H, Ishii J, Takahashi H, Kitagawa F, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Fujiwara W, Hayashi M, Motoyama S, Sarai M, Watanabe E, Izawa H, Ozaki Y. Urinary Liver-Type Fatty-Acid-Binding Protein Predicts Long-Term Adverse Outcomes in Medical Cardiac Intensive Care Units. J Clin Med. 2020 Feb 10;9(2):482.
• Kawai H, Sarai M, Kato Y, Naruse H, Watanabe A, Matsuyama T, Takahashi H, Motoyama S, Ishii J, Morimoto SI, Toyama H, Ozaki Y. Diagnosis of isolated cardiac sarcoidosis based on new guidelines. ESC Heart Fail. 2020 Oct;7(5):2662-2671.
• Miyajima K, Motoyama S, Sarai M, Kawai H, Nagahara Y, Matsumoto R, Fujiwara W, Muramatsu T, Takahashi H, Naruse H, Ishii J, Kondo T, Narula J, Izawa H, Ozaki Y. On-site assessment of computed tomography-derived fractional flow reserve in comparison with myocardial perfusion imaging and invasive fractional flow reserve. Heart Vessels. 2020 Oct;35(10):1331-1340.
• Kusuki H , Tsuchiya Y, Mizutani Y, Nishio M, Oikawa S, Nagata R, Kiriyanagi Y, Horio K, Kojima A, Uchida H, Kojima N, Saito K, Sadanaga T, Hata T.
  QT Variability Index is Correlated with Autonomic Nerve Activity in Healthy Children. Pediatric Cardiology. 2020 Oct;41(7):1432-1437.
• Hirono K, Miyao N, Yoshinaga M, Nishihara E, Yasuda K, Tateno S, Ayusawa M, Sumitomo N, Horigome H, Iwamoto M, Takahashi H, Sato S, Kogaki S, Ohno S, Hata T, Hazeki D, Izumida N, Nagashima M, Ohta K, Tauchi N, Ushinohama H, Doi S, Ichida F; Study group on childhood cardiomyopathy in Japan. A significance of school screening electrocardiogram in the patients with ventricular noncompaction.
  Heart Vessels. 2020 Jul;35(7):985-995
• Suzuki T, Michihata T, Yoshikawa T, Hata T, Matsui H, Fushimi K, Yasunaga H. High-dose versus low-dose intravenous immunoglobulin for treatment of children with Kawasaki disease weighing 25 kg or more. Eur J Pediatr. 2020 Dec;179(12):1901-1907.
• Fujigaki H, Takemura M, Osawa M, Sakurai A, Nakamoto K, Seto K, Fujita T, Hata T, Akiyama H, Doi Y, Saito K. Reliability of serological tests for COVID-19: comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. Heliyon. 2020 Sep 10;6(9):e04929.

• Naruse H, Takahashi H, Ishii J. Authors' response to letter "Prediction of acute kidney injury in intensive care unit patients". Crit Care. 2019 Feb 19;23(1):58.
• Ishikawa M, Muramatsu T, Nanasato M, Nagasaka R, Takatsu H, Yoshiki Y, Hashimoto Y, Ohota M, Okumura M, Naruse H, Ishii J, Ito K, Takahashi H, Kamiya H, Yoshida Y, Ozaki Y. Associations of coronary plaque characteristics by integrated backscatter intravascular ultrasound with detectability of vessel external elastic lamina using optical frequency domain imaging in human coronary arteries: A sub-analysis of the MISTIC-1 trial. Catheter Cardiovasc Interv. 2019 Dec 1;94(7):947-955.

•  服部秀計,池田裕隆,花松智武, 高木悠衣, 島村宥里佳, 熊澤佑之介,中垣勇平, 石田小百合, 高橋知樹, 坂東周治, 大島夕佳, 古田みなみ, 高橋和也,浜渕菜邑, 久永隆治, 坂口英林, 成瀬寛之, 大野良治, 外山宏, 学生健康診断における胸部X線写真診断の人工知能技術を応用したコンピュータ支援検出/診断システムに伴う偽陽性率の検討, 第52回日本総合健診医学会,倉敷 2024年1月26日（金）～27日（土）
• Sakaguchi E, Naruse H, Yamada A, Kawai H, Muramatsu T, Harada H, Ishii J, Sarai M, Yanase M, Izawa H. Prognostic Value of CHA2DS2-VASc score in Patients Hospitalized at Coronary Care Units with Preserved Renal Function. 日本循環器学会総会 2024.
• Visualization of Bronchospasm in Anaphylaxis Induced by Non-Ionic Iodinated Contrast Media via CT Imaging H. Hattori1, Y. Ohno1, A. Teramoto2, S. Ota1, H. Azuma1, E. Sakaguchi1, S. Kobayashi1, H. Toyama1, H. Naruse1; 1Toyoake/JP, 2Nagoya/JP, ECR 2024

•  服部秀計、中村菜穂子、高木玲香、大下悠樹、寺本篤司、坂口 英林、大野良治、成瀬 寛之、小林茂樹、外山宏、ヨード造影剤によるアナフィラキシー発症検出のための予備的検討、第14回　呼吸機能イメージング研究会、2023年1月27日（金）～28日（土）
• Hidekazu Hattori, Yoshiharu Ohno, Seiichiro Ota, Ayumi Watanabe, Eirin Sakaguchi, Hiroyuki Naruse, Reika Takagi, Hiroyuki Azuma, Atsushi Teramoto, Hiroshi Toyama, Shigeki Kobayashi, Imaging Findings for Early Detection of Iodinated Contrast-Induced Anaphylaxis, ECR 2023,Vienna March 1-5, 2023
• Sakaguchi E, Naruse H, Yamada A, Kawai H, Muramatsu T, Harada H, Ishii J, Sarai M, Yanase M, Izawa H. Prognostic value of modified renal angina index in patients hospitalized at Coronary Care Units. 日本循環器学会総会 2023.
• 服部秀計、高木玲香、大下悠樹、寺本篤司、坂口英林、太田誠一郎、花松智武、渡邉あゆみ、山上潤一、安田あゆ子、大野良治、成瀬寛之、小林茂樹、外山宏、ヨード造影剤によるアナフィラキシー発症検出のための予備的検討 - 肺野(細気管支)での検討 、日本医学放射線学会第172回中部地方会、2023.2.11～12
• H. Hattori, Y. Oshita, A. Teramoto, R. Takagi , T. Hanamatsu, H. azuma, S. Ota, A. Watanabe, E. Sakaguchi , Y. Ohno, H. Naruse, S. Kobayashi, H. Toyama.Classification Trial of Anaphylaxis Caused by Nonionic Iodine Contrast Agents Using Machine Learning.  CARS 2023
•  H. Hattori, Y. Ohno, S. Ota, A. Watanabe, E. Sakaguchi, H. Naruse, R. Takagi , H. Azuma, A. Teramoto, H. Toyama, S. Kobayashi.Imaging Findings for Early Detection of Iodinated Contrast-Induced Anaphylaxis.  ACTI 2023

• Sakaguchi E, Naruse H, Yamada A, Kawai H, Muramatsu T, Harada H, Ishii J, Sarai M, Yanase M, Izawa H. Usefulness of modified renal angina index for severe acute kidney injury prediction in patients hospitalized at Coronary Care Units. 日本循環器学会総会 2023. 
•   高橋 知樹, 小澤良之, 服部秀計, 大島夕佳, 濱渕 菜邑, 外山宏, 大野良治、前縦隔腫瘤にて発見された縦隔型悪性中皮腫の一例、徳島、第37回胸部放射線研究会、2023年9月15日(金) 
•  Sakaguchi E, Naruse H, Yamada A, Kawai H, Muramatsu T, Harada H, Ishii J, Sarai M, Yanase M, Izawa H. Usefulness of renal angina index for severe acute kidney injury prediction in patients hospitalized for heart failure. 日本心不全学会 2023.

•  Sakaguchi E, Yamada A, Naruse H, Nishimura H, Kawai H, Muramatsu T, Harada H, Tanizawa S, Ishii J, Izawa H. Impact of changes in left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction. 日本心不全学会 2022.
• H. Hattori, Y. Oshima, N. Hamabuchi, A. Watanabe, M. Nomura, Y. Obama, H. Ikeda, Y. Ohno, H. Toyama; Deep Learning Algorithm for Chest Radiograph: Improvement of Abnormal Lesion Detection Capability in Medical Staffs with Various Experiences,ECR 2022. Vienna July 13-17, 2022
• Sakaguchi E, Yamada A, Naruse H, Nishimura H, Kawai H, Muramatsu T, Harada H, Tanizawa S, Ishii J, Izawa H. Cardiac Myosin-binding Protein C, a New Marker of Cardiac Injury, Predicts One-year Mortality in Patients Hospitalized for Worsening Heart Failure. 日本循環器学会総会 2022.
• Sakaguchi E, Yamada A, Naruse H, Nishimura H, Kawai H, Muramatsu T, Harada H, Tanizawa S, Ishii J, Izawa H. Cardiac Myosin-binding Protein C, a New Marker of Cardiac Injury, Predicts Six-Month Mortality in Patients Hospitalized for Acute Coronary Syndrome. 日本循環器学会総会 2022.

• Sakaguchi E, Yamada A, Naruse H, Nishimura H, Kawai H, Muramatsu T, Harada H, Tanizawa S, Ishii J, Izawa H. Long-term Prognostic Value of Change in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure With Preserved Ejection Fraction. 日本循環器学会総会 2022.

• Naruse H, Ishii J, Nishimura H, Ohta M, Sakaguchi E, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M, Tanizawa S, Sarai M, Watanabe E, Ozaki Y, Izawa H. Prognostic Value of Combination of Urinary Liver-Type Fatty Acid-Binding Protein and Plasma B-Type Natriuretic Peptide for Predicting Long-Term Adverse Outcomes. 日本循環器学会総会 2021.
• Naruse H, Ishii J, Nishimura H, Ohta M, Sakaguchi E, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M, Tanizawa S, Sarai M, Watanabe E, Ozaki Y, Izawa H. Combination of GWTG-HF Risk Score with D-Dimer and NT-proBNP in Patients Hospitalized for Worsening Heart Failure with Preserved Ejection Fraction.日本循環器学会総会 2021.
• Sakaguchi E, Yamada A, Kawada Y, Hoshino N, Hoshino M, Takada K, Yamabe S, Ozaki Y. No improvement in left ventricular GLS after acute heart failure admission suggests worse prognosis in patients with preserved ejection fraction.　日本循環器学会総会2021.

• Naruse H, Ishii J, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Watanabe E, Ozaki Y, Izawa H. Combined Assessment of American Heart Association Get With the Guidelines–Heart Failure Risk Score with Plasma D-Dimer and N-Terminal Pro-B-Type Natriuretic Peptide Levels Improves Prediction of Mortality in Patients Hospitalized for Worsening Heart Failure. AHA 2020.
• 成瀬寛之.救急初期対応を学ぶ-2. 救急現場で知っておくと役立つバイオマーカー.日本循環器学会総会モーニングセミナー2020 .

• Naruse H, Ishii J, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Motoyama S, Hayashi M, Sarai M, Watanabe E, Izawa H, Ozaki Y. Combined Assessment of Urinary Liver-type Fatty-acid Binding Protein and Plasma B-type Natriuretic Peptide Improves Prediction of Long-term Outcomes in Patients Treated at Medical Cardiac Intensive Care Units.AHA2019, Philadelphia, U.S.A., 2019.
• Nishimura　H, Ishii J, Takahashi H, Kitagawa F, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M,Tanizawa A, Naruse H, Sarai M, Watanabe E, Izawa H, Ozaki Y. Urinary Liver-Type Fatty Acid-Binding Protein is More Useful Than Neutrophil Gelatinase-Associated Lipocalin for Predicting Acute Kidney Injury. AHA2019, Philadelphia, U.S.A., 2019.
• Ishii J, Kashiwabara K, Takahashi H, Nishimura H, Kawai H, Muramatsu T, Harada M, Yamada A, Hayashi M, Naruse H, Motoyama S, Sarai M, Watanabe E, Matsuyama Y, Izawa H, Ozaki Y, Nagai R. Circulating Levels of Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Event Risk in Patients With Stable Coronary Artery Disease Treated With High- versus Low-Dose Pitavastatin in the Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy With Pitavastatin in Coronary Artery Disease Trial AHA2019, Philadelphia, U.S.A., 2019.

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• 臨床病態解析学分野へのアクセス ⇒ 大学3号館3階206