藤田医科大学 医学部

Department of Microbiology / Department of Infectious Diseases,
Fujita Health University School of Medicine



  • Suzuki M, Nagano Y, Arakawa Y, Doi Y
  • "ORF-based binarized structure network analysis of plasmids (OSNAp), a novel approach to core gene-independent plasmid phylogeny."
  • Plasmid, 108, 102477 [PubMed]


  • Shields R, Doi Y
  • "Aztreonam Combination Therapy: A Long-Awaited Answer to Metallo-β-Lactamase-Producing Gram-Negatives?"
  • Clin. Infect. Dis., in press [PubMed]
  • Harada S, Ohkushi D, Nakano K, Mitani H, Yamamoto Y, Kamei K, Hayama B
  • "Fatal invasive pulmonary aspergillosis caused by voriconazole-resistant Aspergillus tubingensis in a patient with solid tumor."
  • J. Infect. Chemother., in press [PubMed]
  • Taniguchi Y, Koide S, Maeyama Y, Tamai K, Hayashi W, Tanaka H, Iimura M, Suzuki M, Nagano Y, Arakawa Y, Nagano N.
  • "Predominance of methicillin-resistant Staphylococcus aureus SCCmec type II-CC5 and SCCmec type IV-CC1/CC8 among companion animal clinical isolates in Japan; findings from phylogenetic comparison with human clinical isolates."
  • J. Glob. Antimicrob. Resist., in press [PubMed]
  • Hinenoya A, Ichimura H, Yasuda N, Harada S, Yamada K, Suzuki M, Iijima Y, Nagita A, Albert MJ, Hatanaka N, Awasthi SP, Yamasaki S.
  • "Development of a specific cytolethal distending toxin (cdt) gene (Eacdt)-based PCR assay for the detection of Escherichia albertii."
  • Diagn. Microbiol. Infect. Dis., 95, 119-124 [PubMed]
  • Harada S, Aoki K, Yamamoto S, Ishii Y, Sekiya N, Kurai H, Furukawa K, Doi A, Tochitani K, Kubo K, Yamaguchi Y, Narita M, Kamiyama S, Suzuki J, Fukuchi T, Gu Y, Okinaka K, Shiiki S, Hayakawa K, Tachikawa N, Kasahara K, Nakamura T, Yokota K, Komatsu M, Takamiya M, Tateda K, Doi Y.
  • "Clinical and molecular characteristics of Klebsiella pneumoniae causing bloodstream infections in Japan: occurrence of hypervirulent infections in healthcare."
  • J. Clin. Microbiol., 57, e01206-19 [PubMed]
  • Hoashi K, Harada S, Ishii Y, Aoki K, Ishikawa S, Oshiro Y, Shinzato T.
  • "Community-acquired liver abscess caused by capsular genotype K2-ST375 hypervirulent Klebsiella pneumoniae isolates."
  • IDCases, 17, e00577 [PubMed]
  • Harada S, Aoki K, Okamoto K, Kinoshita O, Nawata K, Ishii Y, Tateda K, Sasaki M, Saga T, Doi Y, Yotsuyanagi H, Moriya K, Ono M.
  • "Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns."
  • Int. J. Infect. Dis., 84, 44-47 [PubMed]
  • Harada S, Aoki K, Ishii Y, Ohno Y, Nakamura A, Komatsu M, Tateda K.
  • "Emergence of IMP-producing hypervirulent Klebsiella pneumoniae carrying pLVPK-like virulence plasmid."
  • Int. J. Antimicrob. Agents, 53, 873-875 [PubMed]
  • Nagano N, Koide S, Hayashi W, Taniguchi Y, Tanaka H, Maeyama Y, Suzuki M, Kimura K, Arakawa Y, Nagano Y.
  • "Population-level transition of capsular polysaccharide types among sequence type 1 group B Streptococcus isolates with reduced penicillin susceptibility during a long-term hospital epidemic."
  • Int. J. Antimicrob. Agents, 53, 203-210 [PubMed]
  • 河合 聡人、山崎 啓之、小田切 優樹
  • "ヒト血清アルブミンとアリピプラゾール複合体のX線結晶構造解析"
  • Photon Factory Activity Report 2018 #36 No. 66 [KEK]


  • Hayashi W, Ohsaki Y, Taniguchi Y, Koide S, Kawamura K, Suzuki M, Kimura K, Wachino JI, Nagano Y, Arakawa Y, Nagano N.
  • "High prevalence of blaCTX-M-14 among genetically diverse Escherichia coli recovered from retail raw chicken meat portions in Japan."
  • Int. J. Food Microbiol., 284, 98-104 [PubMed]
  • Sakurama K, Kawai A, Chuang VTG, Kanamori Y, Osa M, Taguchi K, Seo H, Maruyama T, Imoto S, Yamasaki K, Otagíiri M
  • "Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure"
  • ACS Omega, 3, 13790-13797 [PubMed]
  • PDB ID: 6a7p
  • Harada S, Doi Y
  • "Hypervirulent Klebsiella pneumoniae: a call for consensus definition and international collaboration."
  • J. Clin. Microbiol., 56, e00959-18 [PubMed]
  • Harada S, Ishii Y, Saga T, Aoki K, Tateda K
  • "Molecular epidemiology of Klebsiella pneumoniae K1 and K2 isolates in Japan."
  • Diagn. Microbiol. Infect. Dis., 91, 354-359 [PubMed]
  • Takatani Y, Ono K, Suzuki H, Inaba M, Sawada M, Matsuda N.
  • "Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration."
  • Lab. Invest., 98, 629-639 [PubMed]
  • Osaka S, Okuzumi K, Koide S, Tamai K, Sato T, Tanimoto K, Tomita H, Suzuki M, Nagano Y, Shibayama K, Arakawa Y, Nagano N
  • "Genetic shifts in methicillin-resistant Staphylococcus aureus epidemic clones and toxin gene profiles in Japan: comparative analysis among pre-epidemic, epidemic and post-epidemic phases."
  • J. Med. Microbiol., 67, 392-399 [PubMed]
  • Aoki K, Harada S, Yahara K, Ishii Y, Motooka D, Nakamura S, Akeda Y, Iida T, Tomono K, Iwata S, Moriya K, Tateda K.
  • "Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo."
  • Antimicrob. Agents Chemother., 62, e02091-17 [PubMed]
  • Ito R, Pacey MP, Mettus RT, Sluis-Cremer N, Doi Y
  • "Origin of the plasmid-mediated fosfomycin resistance gene fosA3"
  • J. Antimicrob. Chemother., 73, 373-376 [PubMed]
  • Kawai A, Yamasaki K, Enokida T, Miyamoto S, Otagiri M
  • "Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate"
  • Biochem. Biophys. Rep., 13, 78-82 [PubMed]
  • PDB ID: 5yoq
  • Matsui M, Suzuki M, Suzuki M,, Yatsuyanagi J, Watahiki M, Hiraki Y, Kawano F, Tsutsui A, Shibayama K, Suzuki S.
  • "Distribution and Molecular Characterization of Acinetobacter baumannii International Clone II Lineage in Japan"
  • Antimicrob. Agents Chemother., 62, e02190-17 [PubMed]
  • Norizuki C, Kawamura K, Wachino JI, Suzuki M, Nagano N, Kondo T, Arakawa Y
  • "Detection of Escherichia coli Producing CTX-M-1-Group Extended-Spectrum β-Lactamases from Pigs in Aichi Prefecture, Japan, between 2015 and 2016."
  • Jpn. J. Infect. Dis., 23, 33-38 [PubMed]
  • 河合 聡人、山崎 啓之、小田切 優樹
  • "ヒト血清アルブミンと4フェニル酪酸ナトリウム複合体のX線結晶構造解析"
  • Photon Factory Activity Report 2017 #35 No. 35 [KEK]


  • Ito R, Tomich AD, McElheny CL, Mettus R, Sluis-Cremer N, Doi Y
  • "Inhibition of fosfomycin resistance protein FosA by phosphonoformate (foscarnet) in multidrug-resistant Gram-negative pathogens"
  • Antimicrob. Agents Chemother., 61, e01424-17 [PubMed]
  • Lucas A, Ito R, Mustapha MM, McElheny CL, Mettus RT, Bowler SL, Kantz SF, Pacey MP, Pasculle AW, Cooper VS, Doi Y
  • "Frequency and Mechanisms of Spontaneous Fosfomycin Nonsusceptibility Observed upon Disk Diffusion Testing of Escherichia coli"
  • J. Clin. Microbiol., 55, e01368-17 [PubMed]
  • Ito R, Mustapha MM, Tomich AD, Callaghan JD, McElheny CL, Mettus RT, Shanks RMQ, Sluis-Cremer N, Doi Y
  • "Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene."
  • MBio., 8, e00749-17 [PubMed]
  • Chusri S, Chongsuvivatwong V, Rivera JI, Silpapojakul K, Singkhamanan K, McNeil E, Doi Y
  • "Molecular epidemiology and spatiotemporal analysis of hospital-acquired Acinetobacter baumannii infection in a tertiary care hospital in southern Thailand"
  • J. Hosp. Infect., 95, 53-58 [PubMed]
  • Jiménez A, Castro JG, Munoz-Price LS, de Pascale D, Shimose L, Mustapha MM, Spychala CN, Mettus RT, Cooper VS, Doi Y
  • "Outbreak of KPC-producing Citrobacter freundii at a tertiary acute care facility in Miami, Florida"
  • Infect. Control Hosp. Epidemiol., 38, 320-326 [PubMed]
  • Yassin MH, Hariri R, Hamad Y, Ferrelli J, McKibben Leeanna, Doi Y
  • "Disposable bronchoscope model for simulating endoscopic reprocessing and surveillance cultures"
  • Infect. Control Hosp. Epidemiol., 38, 136-142 [PubMed]
  • Liu YY, Chandler CE, Leung LM, McElheny CL, Mettus RT, Shanks RM, Liu JH, Goodlett DR, Ernst RK, Doi Y
  • "Structural modification of lipopolysaccharide conferred by mcr-1 in Gram-negative ESKAPE pathogens"
  • Antimicrob. Agents Chemother., 61, e00580-17 [PubMed]
  • Iwasaki Y, Inokuchi R, Harada S, Aoki K, Ishii Y, Shinohara K.
  • "Bacterial Meningitis Caused by Hypervirulent Klebsiella pneumoniae Capsular Genotype K54 with Development of Granuloma-like Nodal Enhancement in the Brain during the Subacute Phase"
  • Intern. Med., 56, 373-376 [PubMed]
  • Norizuki C, Wachino JI, Suzuki M, Kawamura K, Nagano N, Kimura K, and Arakawa Y
  • "Specific blaCTX-M-8/IncI1 Plasmid Transfer among Genetically Diverse Escherichia coli Isolates between Humans and Chickens."
  • Antimicrob. Agents Chemother., 61, e00663-17 [PubMed]
  • Kawai A, Chuang TGV, Kouno Y, Yamasaki K, Miyamoto S, Anraku M, Otagiri M
  • "Crystallographic analysis of the Ternary Complex of Octanoate and N-acetyl-L-methionine with Human Serum Albumin Reveals the Mode of their Stabilizing Interactions"
  • BBA - Proteins and Proteomics, 1865, 979-984 [PubMed]
  • PDB ID: 5x52
  • Yamasaki K, Enokida T, Taguchi K, Miyamura S, Kawai A, Miyamoto S, Maruyama T, Seo H, Otagiri M
  • "Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin"
  • J. Pharm. Sci., 106, 2860-2867 [PubMed]
  • Inaba M, Matsuda N, Banno H, Jin W, Wachino JI, Yamada K, Kimura K, Arakawa Y.
  • "In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine."
  • Int. J. Antimicrob. Agents, 48, 680-689 [PubMed]
  • Takimoto K, Wang Q, Suzuki D, Katayama M, Hayashi Y.
  • "Clinical efficacy of piperacillin/tazobactam in the treatment of complicated skin and soft tissue infections."
  • Expert Opin. Pharmacother., 18, 1027-1034 [PubMed]
  • 稲葉 正人, 髙谷 悠大, 東 倫子, 江嶋 正志, 沼口 敦, 松田 直之
  • "MicroScan WalkAway® prompt法で測定した最小阻止濃度がバンコマイシン治療に与える影響の検討"
  • 日本集中治療医学会雑誌, 24, 417-420 [DOI]
  • 河村 一郎,関谷 紀貴,荒岡 秀樹,根井 貴仁,原田 壮平,倉井 華子,片浪 雄一,杦木 優子,坂本 史衣, 大曲 貴夫
  • "7施設におけるメチシリン耐性黄色ブドウ球菌サーベイランス(2015年度)"
  • 日本環境感染学会誌, 32, 135-140 [DOI]
  • 佐々木 俊治, 山下 裕之, 三森 明夫
  • "多発性筋炎に対する治療経過中に播種性糞線虫症を発症し消化管出血を起こした1例"
  • 感染症誌, 91, 420-424 [感染症誌]
  • 鈴木 大介, 馳 亮太, 橋本 幸平, 山田 智, 戸口 明宏, 大塚 喜人, 細川 直登
  • "Bacteroides属およびParabacteroides属菌血症―亀田総合病院における7年間138症例の臨床的特徴―"
  • 臨床微生物, 27, 168-176 [日本臨床微生物学雑誌]
  • 河合 聡人、小田切 優樹
  • "立体構造に基づくオクタン酸ナトリウム及び N-アセチル-L-メチオニンのヒト血清アルブミン安定化効果に関する考察"
  • Photon Factory Activity Report 2016 #34 No. 52 [KEK]