業績 | 藤田医科大学精神・神経病態解明センター　老化制御学部門

業績

2025

Kim D, Morikawa S, Miyawaki M, Nakagawa T, Ogawa S, Kase Y*. Sarcopenia prevention in older adults: Effectiveness and limitations of non-pharmacological interventions. Osteoporos Sarcopenia. 2025 Jun;11(2 Suppl):65-72. *Corresponding author

Hashimoto S, Hosoi T, Yakabe M, Yunoki M, Matsumoto S, Kase Y, Miyawaki M, Ishii M, Ogawa S. Preventative approaches to falls and frailty. Osteoporos Sarcopenia. 2025 Jun;11(2 Suppl):50-53.

Kim D, Morikawa S, Nakagawa T, Okano H, Kase Y*. Advances in brain ischemia mechanisms and treatment approaches: Recent insights and inflammation-driven risks. Exp Neurol. 2025 Apr;386:115177. *Corresponding author

Kase Y, Morikawa S, Okano Y, Hosoi T, Yasui T, Taki-Miyashita Y, Yakabe M, Goto M, Ishihara K, Ogawa S, Nakagawa T, Okano H. Multi-organ frailty is enhanced by periodontitis-induced inflammaging. Inflamm Regen. 2025 Feb 3;45(1):3.

Okano Y, Okano H, Kase Y*. Spinal cord injury regenerative therapy development: integration of design of experiments. Neural Regen Res. 2025 Sep 1;20(9):2571-2573. *Corresponding author

Matsuda KM, Umeda-Kameyama Y, Iwadoh K, Miyawaki M, Yakabe M, Ishii M, Ogawa S, Akishita M, Sato S, Yoshizaki A. Artificial intelligence and omics-based autoantibody profiling in dementia. Front Immunol. 2025 May 8;16:1537659.

Hoshi K, Shibasaki K, Yakabe M, Hosoi T, Matsumoto S, Yamada S, Hashimoto S, Akishita M, Ogawa S. Relationship between decreased activities of daily living, decreased physical strength and future weight loss in community-dwelling older adults. Geriatr Gerontol Int. 2025 Mar;25(3):418-424.

2024

Sato N, Goyama S, Chang YH, Miyawaki M, Fujino T, Koide S, Denda T, Liu X, Ueda K, Yamamoto K, Asada S, Takeda R, Yonezawa T, Tanaka Y, Honda H, Ota Y, Shibata T, Sekiya M, Isobe T, Lamagna C, Masuda E, Iwama A, Shimano H, Inoue JI, Miyake K, Kitamura T. Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity. Nat Cardiovasc Res. 2024 Dec;3(12):1568-1583. doi: 10.1038/s44161-024-00579-w.

Okano Y, Kase Y*, Suematsu Y, Nakamura M, Okano H. Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflamm Regen. 2024 Mar 13;44(1):10. * Senior author. * Senior author

Hino U, Tamura R, Yo M, Kase Y, Tsuda N, Miyauchi T, Sogano J, Karatsu K, Miwa T, Toda M. Case report: meningeal lymphangiogenesis around ependymoma forming along the dura matter. Front Oncol. 2024 Jan 12;13:1340167.

Hosoi T, Yakabe M, Hashimoto S, Akishita M, Ogawa S. The roles of sex hormones in the pathophysiology of age-related sarcopenia and frailty. Reprod Med Biol. 2024 Mar 11;23(1):e12569.

Hashimoto S, Hosoi T, Yakabe M, Matsumoto S, Hashimoto M, Akishita M, Ogawa S. Exercise-induced vitamin D receptor and androgen receptor mediate inhibition of IL-6 and STAT3 in muscle. Biochem Biophys Rep. 2023 Dec 21;37:101621.

2023

Suematsu Y, Nagoshi N, Shinozaki M, Kase Y, Saijo Y, Hashimoto S, Shibata T, Kajikawa K, Kamata Y, Ozaki M, Yasutake K, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H. Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation. Inflamm Regen. 2023 Oct 16;43(1):50.

Tamura R, Miyoshi H, Imaizumi K, Yo M, Kase Y, Sato T, Sato M, Morimoto Y, Sampetrean O, Kohyama J, Shinozaki M, Miyawaki A, Yoshida K, Saya H, Okano H, Toda M. Gene therapy using genome-edited iPS cells for targeting malignant glioma. Bioeng Transl Med. 2022 Sep 10;8(5):e10406.

Imai R, Tamura R, Yo M, Sato M, Fukumura M, Takahara K, Kase Y, Okano H, Toda M. Neuroprotective Effects of Genome-Edited Human iPS Cell-Derived Neural Stem/Progenitor Cells on Traumatic Brain Injury. Stem Cells. 2023 Jun 15;41(6):603-616.

Kase Y, Sonn I, Goto M, Murakami R, Sato T, Okano H. The original strain of SARS-CoV-2, the Delta variant, and the Omicron variant infect microglia efficiently, in contrast to their inability to infect neurons: Analysis using 2D and 3D cultures. Exp Neurol. 2023 May;363:114379.

2022

Yamada H, Kase Y*, Okano Y, Kim D, Goto M, Takahashi S, Okano H, Toda M. Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death. Inflamm Regen. 2022 Dec 14;42(1):61. doi: 10.1186/s41232-022-00236-4. * Senior author

Okano Y, Kase Y*, Okano H. A set-theoretic definition of cell types with an algebraic structure on gene regulatory networks and application in annotation of RNA-seq data. Stem Cell Reports. 2023 Jan 10;18(1):113-130. doi: 10.1016/j.stemcr.2022.10.015. * Senior author

Kase Y, Sato T, Okano Y, Okano H.The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization. iScience. 25.104089.2022.

Kitago M, Kase Y *, Iwata Y, Suwa Y, Tsuchiya H, Hanata N, Kojima T, Ogawa S, Fujio K, Akishita M. Deteriorating anemia in an 86-year-old man was improved by prednisolone. Geriatr Gerontol Int., 20(11), 1091–1092. 2022. *Corresponding author

Sugimoto H, Yumura W, Yamaguchi Y, Yamanaka N, Hashimoto S, Arai M, Matsuno S, Shimizu A, Arai T, Itabashi M, Takei T. Identification of histopathological and clinical spectrum of diabetic kidney disease based on an unsupervised hierarchical clustering analysis of elderly autopsy specimens. Nephrology (Carlton). 2022 Aug;27(8):701-711.

2021

Kase Y & Okano H.Neurological pathogenesis of SARS-CoV-2 (COVID-19): from virological features to clinical symptoms. Inflamm Regen. 41(1), 15.2021.

Miyawaki M, Aoyama R, Ishikawa J, Harada K. Primary cardiac B cell lymphoma in an immunocompetent patient. BMJ Case Rep. 2021 Jul 26;14(7):e243068.

2020

Kase Y, & Okano H. Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders. Inflamm Regen. 40, 32. 2020.

Kase Y, Shimazaki T, Okano H. Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age? Inflamm Regen. 40, 10. 2020

2019

Kase Y, Otsu K, Shimazaki T, & Okano H. Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling. Stem cell reports, 12(6), 1313–1328. 2019.

Kase Y, Hattori Y, Umeda-Kameyama Y, Kojima T, Ogawa S, Akishita M.Improvement in polypharmacy and medication regimen complexity among older inpatients with dementia in a geriatric ward. Geriatr Gerontol Int., 19(5), 461–462. 2019.

2018

Okubo T, Nagoshi N, Kohyama J, Tsuji O, Shinozaki M, Shibata S, Kase Y Matsumoto M, Nakamura M, & Okano H. Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury. Stem cell reports, 11(6), 1416–1432. 2018.