Department of Regulatory Science, Interdepartmental Collaboration Unit,
Faculties of Medical Technology and Radiological technology,
Fujita Health University

News & Topics

  • August 23, 2021
 Our research on brain-gut correlation is introduced in the Fuji Evening News (https://www.zakzak.co.jp/lif/news/210823/hea2108230001-n1.html)
  • August 19, 2021
 Dr. Kunisawa won the BPNP2021 Featured Presentation Award at the 43rd Joint Annual Meeting of the Japanese Society of Biological Psychiatry and the 51st Annual Meeting of the Japanese Society of Neuropsychopharmacology.
  • June 26, 2021
 Ms. Kurahashi, a graduate student, won the Best Presentation Award at the 139th Annual Meeting of the Kinki Division of the Japanese Pharmacological Society.

Introduction

Regulatory science is defined as "science for adapting the achievements of technology to social and human needs in the most optimal way, by making precise prediction, evaluation, and judgment based on evidence." This field develops basic and clinical research as a regulatory science in medical care and aims to apply it to professionals including clinical laboratory technicians, clinical engineers, radiologists, and medical radiologists. In addition, graduate schools train drug development researchers, clinical research coordinators, genetic counselors, and embryo culture technicians by conducting research and education that takes advantage of the characteristics of each medical job.

Members

Faculty members

Medical Technology

Radiological Technology

Graduate students

Doctor’s course: Aika Kosuge (D2), Hisayoshi Kubota (D2)
Master’s course: Masaya Hasegawa (M2), Hitomi Kurahashi (M2), Yumika Sugawara (M2), Mitsuki Hara (M2), Shuhei Yamagishi (M1), Tomoki Kawai (M1), Yoshiyuki Kariya (M1), Moeka Tanabe (M1), Kazuyoshi Ohtoshi (M1), 10 other working graduate students.

Research Theme

・Elucidation of the pathophysiology of chromosomal structural abnormalities
・Genetic counseling for Emanuel syndrome

Transsopid crossovers, as assessed by FISH

Chromosome changes vary widely and may go unnoticed without symptoms, but they can be serious if they affect the function or excess or deficiency of genes. t(11;22)(q23;q11) chromosome translocation carriers have no symptoms, but when they have children, they may be born with an excess of chromosome 22 derivative. This is known as Emanuel syndrome. We are investigating the mechanism and pathogenesis of this chromosome change, as well as the support system for patients and their families. (Tamae Ohye)

・Elucidation of the pathology and etiology of psycho-neurological diseases
・Development of biomarkers and therapeutic agents based on pathophysiology

Behavioral tests to evaluate cognitive functions

We are conducting brain and nervous system research in the fields of molecular biology and neuropsychobehavioral pharmacology for psychiatric disorders, such as Alzheimer's disease, schizophrenia, drug dependence, bipolar disorder, ADHD, depression, and autism. We also carry out translational research to develop novel therapeutic agents, phytochemicals, and diagnostic biomarkers based on our findings. We conduct translational research. (Akihiro Mouri)

・Elucidation of the pathogenesis of neuropsychiatric disorders focused on neuron-glial network.
・Effects of abnormalities in peripheral–central connections on brain functions

In situ hybridization to investigate gene expression

The central nervous system is composed of not only neurons but also glial cells. Recently, it has been reported that not only abnormalities in neurons but also glial function are implicated in the development of neuropsychiatric disorders. We examine how abnormalities in glial cells influence on neuronal functions and development of neuropsychiatric disorders, using glial cell-specific genetic manipulation.
In recent years, it has been reported that abnormalities in the peripheral nervous system, such as the intestinal microbiota and peripheral immunity, also play a role in the development of neuropsychiatric disorders. By analyzing the composition of microbiota and peripheral immune cells, we study how abnormalities in the peripheral-central nervous system affect brain function. (Kazuo Kunisawa)

・Rehabilitation Effect Based on Alteration of Brain Molecules and Improvement of Paralysis in Rats with Cerebral Infarction.<br>・Development of Rehabilitation Training and Drug Combination Therapy for Rats with Cerebral Infarction

Rotarod test to evaluate the degree of paralysis after cerebral infarction

The purpose of this study is to identify the factors that determine the rehabilitation effect in a rat model of cerebral infarction through basic research. In this study, we compared the effects of spontaneous motor training using a running wheel cage on cerebral infarction model rats with and without motor training using the Nanakuri Forepaw stage (NAF stage), which we developed as an evaluation method for forelimb paralysis applicable to rats, and the rotarod test, which evaluates motor coordination and balance sensation in a combined manner. As a result, significant improvement in paralysis and motor function was observed. In addition, we are currently analyzing the changes in bioactive substances in the cerebral cortex and basal ganglia during the recovery process of paralysis. If the mechanisms and functional molecules involved in the recovery process of paralysis after stroke are clarified, it is expected that efficient and effective treatment methods for rehabilitation to improve paralysis will become clearer. (Kenmei Mizutani)

・Analysis of Environmental Effect of Radiations and Dosimetry<br>・Analysis of Radiation Risk Communication

Dose estimation by experimental

There are various natural and artificial radiation sources around us.
For example, radiation is effectively used for therapy and diagnosis in the medical field. It is important to analyze the behavior of radiation and dosimetry by experiment and calculation to ensure the safety of the facilities and to develop safety regulatory criteria.
In addition, there has been increasing interest in radiation risk communication among radiation experts. It is a big challenge for radiation experts and the public to learn and believe in each other. (Sumi Yokoyama)

Annual Events

Journal club

Once a week, faculty members and graduate students introduce and discuss the most recent and excellent articles using slides.

Research progress meeting

Research progress Meeting

Once a month, graduate students present the progress of their research projects using slides. Once every three months, we hold a joint meeting with the Advanced Diagnostic System team.

FUJITA Neuroscience Seminar

Once a month, laboratories in the neuroscience field at Fujita Health University hold a joint meeting to improve the research level by fostering young researchers at the university and strengthen collaborations between on-site organizations.

Academic conference presentations

Faculty members and graduate students, including the Pharmacological Society and the Neurochemistry Society, present at the conference. At the Fujita Medical Society, undergraduate students present the contents of graduation research.

Laboratory trip

Laboratory trip

Once a year, we travel together with the Advanced Diagnostic System development team.

Recreation

We hold wine parties, year-end parties, sports events, etc.

Photo Gallery

  • Birthday celebrations

  • Laboratory trips

  • FUJITA neuroscience seminar

  • Academic meeting
    (Fujita medical society)

  • Academic meeting (BPNP2021)

  • Graduation Ceremony

Academic Activities

Publications

2021

  • Kosuge A, Kunisawa K, Arai S, Sugawara Y, Shinohara K, Iida T, Wulaer B, Kawai T, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress. Brain Behav Immun. 2021 Aug;96:200-211.
  • Noda Y, Soeda K, Uchida M, Goto S, Ito T, Kitagaki S, Mamiya T, Yoshimi A, Ozaki N, Mouri A. Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine. Behav Brain Res. 2021 Jun 25;408:113284.
  • Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H. Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways. J Biol Chem. 2021 Jan-Jun;296:100544.
  • Wulaer B, Kunisawa K, Tanabe M, Yanagawa A, Saito K, Mouri A, Nabeshima T. Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice. Mol Brain. 2021 Feb 28;14(1):43.
  • Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Fujigaki S, Fujigaki H, Yamamoto Y, Nabeshima T, Saito K. Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid. Behav Brain Res. 2021 May 7;405:113191.
  • Ito T, Hiramatsu Y, Mouri A, Yoshigai T, Takahashi A, Yoshimi A, Mamiya T, Ozaki N, Noda Y. Involvement of PKCβI-SERT activity in stress vulnerability of mice exposed to twice-swim stress. Neurosci Res. 2021 Oct;171:83-91.
  • Suento WJ, Kunisawa K, Wulaer B, Kosuge A, Iida T, Fujigaki S, Fujigaki H, Yamamoto Y, Tanra AJ, Saito K, Mouri A, Nabeshima T. Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced depression-like behavior through inhibition of indoleamine 2,3-dioxygenase 1 expression in mice. J Neurochem. 2021 Jun;157(6):1963-1978.
  • Miura H, Kawamura Y, Ohye T, Hattori F, Kozawa K, Ihira M, Yatsuya H, Nishizawa H, Kurahashi H, Yoshikawa T. Inherited Chromosomally Integrated Human Herpesvirus 6 Is a Risk Factor for Spontaneous Abortion. J Infect Dis. 2021 May 28;223(10):1717-1723.

2020

  • Wulaer B, Kunisawa K, Kubota H, Suento WJ, Saito K, Mouri A, Nabeshima T. Prefrontal cortex, dorsomedial striatum, and dentate gyrus are necessary in the object-based attention test in mice. Mol Brain. 2020 Dec 14;13(1):171.
  • Koizumi H, Hiraga T, Oharomari LK, Hata T, Shima T, Yook JS, Okamoto M, Mouri A, Nabeshima T, Soya H. Preventive role of regular low-intensity exercise during adolescence in schizophrenia model mice with abnormal behaviors. Biochem Biophys Res Commun. 2021 Jan 1;534:610-616.
  • Kunisawa K, Hatanaka N, Shimizu T, Kobayashi K, Osanai Y, Mouri A, Shi Q, Bhat MA, Nambu A, Ikenaka K. Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscleactivity in vivo. Mol Brain. 2020 Nov 23;13(1):159.
  • Cantone MC, Ginjaume M, Martin CJ, Hamada N, Yokoyama S, Bordy JM, Dauer L, Durán A, Jeffries C, Harris W, Kashirina O, Koteng AO, Michelin S, Sudchai W. Report of IRPA task group on issues and actions taken in response to the change in eye lens dose limit. J Radiol Prot. 2020 Nov 21;40(4):1508-1533.
  • Noda Y, Uchida M, Mouri A, Yamada S, Goto S, Kitagaki S, Mamiya T, Kushima I, Arioka Y, Ozaki N, Yoshimi A. Involvement of nicotinic acetylcholine receptors in behavioral abnormalities and psychological dependence in schizophrenia-like model mice. Eur Neuropsychopharmacol. 2020 Dec;41:92-105.
  • Li J, Durose WW, Ito J, Kakita A, Iguchi Y, Katsuno M, Kunisawa K, Shimizu T, Ikenaka K. Exploring the factors underlying remyelination arrest by studying the post-transcriptional regulatory mechanisms of cystatin F gene. J Neurochem. 2021 Jun;157(6):2070-2090.
  • Ito T, Hiramatsu Y, Uchida M, Yoshimi A, Mamiya T, Mouri A, Ozaki N, Noda Y. Involvement of protein kinase C beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice. Neurochem Int. 2020 Nov;140:104826.
  • Inoue K, Miura H, Hoshino A, Kamiya T, Tanita K, Ohye T, Park MJ, Yanagimachi M, Takagi M, Imai K, Morio T, Yoshikawa T, Kanegane H. Inherited chromosomally integrated human herpesvirus-6 in a patient with XIAP deficiency. Transpl Infect Dis. 2020 Oct;22(5):e13331.
  • Wulaer B, Kunisawa K, Hada K, Jaya Suento W, Kubota H, Iida T, Kosuge A, Nagai T, Yamada K, Nitta A, Yamamoto Y, Saito K, Mouri A, Nabeshima T. Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus. J Neurochem. 2021 May;157(3):642-655.
  • Mouri A, Lee HJ, Mamiya T, Aoyama Y, Matsumoto Y, Kubota H, Huang WJ, Chiou LC, Nabeshima T. Hispidulin attenuates the social withdrawal in isolated disrupted-in-schizophrenia-1 mutant and chronic phencyclidine-treated mice. Br J Pharmacol. 2020 Jul;177(14):3210-3224.
  • Sakurai M, Yamamoto Y, Kanayama N, Hasegawa M, Mouri A, Takemura M, Matsunami H, Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Boku AS, Nagashima W, Tonoike T, Kurita K, Ozaki N, Nabeshima T, Saito K. Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder. Sci Rep. 2020 Feb 6;10(1):1961.
  • Miura H, Ohye T, Kozawa K, Hattori F, Kawamura Y, Ihira M, Kurahashi H, Yoshikawa T. Coinfection With Human Herpesvirus (HHV)-6B in Immunocompetent, Healthy Individuals With Chromosomally Integrated HHV-6A. J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):175-178.
  • Takahashi Y, Wakita H, Mizutani K, Watanabe A, Sonoda S, Tomimoto H. Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat. Neuroreport. 2020 Jan 27;31(2):148-155.

2019

  • Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K. Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma. Cancer Sci. 2019 Oct;110(10):3061-3067.
  • Yoshida Y, Fujigaki H, Kato K, Yamazaki K, Fujigaki S, Kunisawa K, Yamamoto Y, Mouri A, Oda A, Nabeshima T, Saito K. Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues. Sci Rep. 2019 Jul 15;9(1):10243.
  • Lu Q, Mouri A, Yang Y, Kunisawa K, Teshigawara T, Hirakawa M, Mori Y, Yamamoto Y, Libo Z, Nabeshima T, Saito K. Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. Behav Brain Res. 2019 Oct 17;372:112053.
  • Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, Morikawa M, Nabeshima T, Ozaki N, Yamamoto Y, Saito K. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. J Affect Disord. 2019 Aug 1;255:168-176
  • Yokoyama S, Hamada N, Tsujimura N. Recent discussions toward regulatory implementation of the new occupational equivalent dose limit for the lens of the eye and related studies in Japan. Int J Radiat Biol. 2019 Aug;95(8):1103-1112.
  • Fujigaki H, Mouri A, Yamamoto Y, Nabeshima T, Saito K. Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia. Neurochem Int. 2019 May;125:1-6.
  • Hasegawa S, Yoshimi A, Mouri A, Uchida Y, Hida H, Mishina M, Yamada K, Ozaki N, Nabeshima T, Noda Y. Acute administration of ketamine attenuates the impairment of social behaviors induced by social defeat stress exposure as juveniles via activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Neuropharmacology. 2019 Apr;148:107-116.
  • Yamamoto Y, Yamasuge W, Imai S, Kunisawa K, Hoshi M, Fujigaki H, Mouri A, Nabeshima T, Saito K. Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling. Sci Rep. 2018 Oct 29;8(1):15917.
  • Tran HQ, Shin EJ, Hoai Nguyen BC, Phan DH, Kang MJ, Jang CG, Jeong JH, Nah SY, Mouri A, Saito K, Nabeshima T, Kim HC. 5-HT<sub>1A</sub> receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKCδ and p47phox. Food Chem Toxicol. 2019 Jan;123:125-141.

Access

  • Access to Regulatory Science ⇒ FHU 3rd Building 332