Division of Human Imaging
Projects
The goal of the Human Imaging Division is to elucidate the multilevel pathogenesis of neurodegenerative diseases based on brain imaging. We are conducting cutting-edge multimodal brain imaging research in close collaboration with the Department of Radiology, aiming at the development of ultra-early diagnosis methods and innovative biomarkers. We also collect brain images and biological samples, and use AI and mathematical models to assess the relationship between brain imaging findings and multi-level pathophysiological conditions to discover new therapeutic targets.
Members
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Watanabe Hirohisa Neurology Professor
We have been building a large-scale registry of high-quality clinical data, brain images, and biological samples for neurodegenerative diseases, and using this registry to conduct network analysis, mathematical modeling, and consortium-based studies of molecular pathology.
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Yasuaki Mizutani Lecturer, Department of Neurology
I am promoting research on biomarkers involved in the pathogenesis of neurodegenerative diseases through the high-quality storage of biological samples and new methods of measurement/analysis in cooperation with investigators in our university and other institutions, and I am engaged in the establishment/management of a registry system for patients with neurodegenerative diseases and healthy adults.
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Ryunosuke Nagao Assistant Professor, Department of Neurology
I am analyzing clinical data on neurodegenerative diseases, represented by multiple system atrophy, and brain function images to clarify the pathogenesis of these diseases for early diagnosis/therapeutic intervention and the development of specific biomarkers.
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Toshiki Maeda Assistant Professor, Department of Neurology
I am promoting research to clarify the pathogenesis of Parkinson’s disease using procedures, such as cerebral blood flow SPECT, adopting the latest statistical analysis methods. Results regarding the etiology of a reduction in primary visual cortex blood flow in the presence of this disease have been obtained.
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Fumihiko Banno Assistant Professor, Department of Neurology
I am promoting research for the early diagnosis of neurodegenerative diseases, such as progressive supranuclear palsy and Parkinson’s disease, using the latest MRI methods, including quantitative susceptibility imaging.
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Kazutaka Hayashi Assistant Professor, Department of Neurology
I am investigating the clinical and image characteristics of diseases, including posterior spinal artery syndrome, useful for diagnosis and treatment by comparing/analyzing MRI findings of the spinal cord and their serial changes.
Main publications
- Kawabata K, Bagarina E, Watanabe H, et al. Bridging Large-Scale Cortical Networks: Integrative and Function-Specific Hubs in the Thalamus. iScience. 2021, https://doi.org/10.1016/j.isci.2021.103106
- Bagarinao E, Watanabe H, Maesawa S, et al. Identifying the brain’s connector hubs at the voxel level using functional connectivity overlap ratio. Neuroimage 2020;222:117241.
- Choy SW, Bagarinao E, Watanabe H, et al. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. Hum Brain Mapp 2020;41(12):3198-3211
- Ogura A, Watanabe H, Kawabata K, et al. Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement. EBioMedicine. 2019;47:506-517.
- Bagarinao E, Watanabe H, Maesawa S, et al. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. Neuroimage. 2018;169:134-144.
Information
Division of Human Imaging(Neurology, School of Medicine)
【Address】
Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
【Contact】
E-mail:sinkeinaika(at)yahoo.co.jp
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