Division of Neurophysiology

Projects

Our laboratory uses mice to study the neural mechanisms underlying animal behavior based on sensory preferences by means of electrophysiological measurements and optogenetics. In particular, we focus on the neural pathways that convert tactile sensations into tactile preferences and the neural circuit mechanisms of social behaviors in which social touches play an essential role.

Members

Takayuki Yamashita

Takayuki Yamashita Professor

The goal of my lab is to understand the mechanisms of perception and cognition at the synaptic, cellular, and circuit levels in animal models. We conduct research by actively incorporating new technologies for electrophysiology, imaging and behavioral analysis.

Takeshi Kanda

Takeshi Kanda Senior Assistant Professor

I investigate how information processing in the brain changes when we alter our behaviors and thoughts. My research employs electrophysiological and imaging techniques. In particular, I hope to contribute to understanding neurological disease and new treatments.

Kansai Fukumitsu

Kansai Fukumitsu Assistant Professor

My research seeks to elucidate the molecular and cellular mechanisms underlying social and emotional behavior in mammals. Using molecular biology and behavioral neuroscience, I hope to uncover the molecular and neural basis of behaviors like aggression, loneliness and affiliation.

Main publications

  1.  Li W-R, Nakano T, Mizutani K, Matsubara T, Kawatani M, Mukai Y, Danjo T, Ito H, Aizawa H, Yamanaka A, Petersen CCH, Yoshimoto J, Yamashita T. Neural mechanisms underlying uninstructed orofacial movements during reward-based learning behaviors. Current Biology 33, 3436–3451, 2023.
  2. Fukumitsu K, Kaneko M, Maruyama T, Yoshihara C, Huang AJ, McHugh TJ, Itohara S, Tanaka M, Kuroda KO. Amylin-Calcitonin receptor signaling in the medial   preoptic area mediates affiliative social behaviors in female mice. Nature Communications 13, 709, 2022. 
  3. Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takizawa H, Tsunoda SP, Horigane S, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, Yamashita T. Remote control of neural function by X-ray-induced scintillation. Nature Communications 12, 4478, 2021.
  4. Yamashita T, Petersen CCH. Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior. eLife 5, e15798, 2016.
  5. Yamashita T, Pala A, Pedrido L, Kremer Y, Welker E, Petersen CCH. Membrane potential dynamics of neocortical projection neurons driving target-specific signals. Neuron 80, 1477-1490, 2013. 
  6. Yamashita T, Eguchi K, Saitoh N, von Gersdorff H, Takahashi T. Developmental shift to a mechanism of synaptic vesicle endocytosis requiring Ca2+ nanodomain. Nature Neuroscience 13, 838-844, 2010.
  7. Yamashita T, Hige T, Takahashi T. Vesicle endocytosis requires dynamin-dependent GTP hydrolysis at a fast CNS synapse. Science 307, 124-127, 2005.

Information

Division of Neurophysiology(Physiology II, School of Medicine)

【Address】
#604, 1st building, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
【Contact】
E-mail:takayuki.yamashita(at)fujita-hu.ac.jp / Tel:+81-562-93-2465
※ Please replace “(at)” with “@”.