Division of Neurochemistry

Projects

Preemptive medicine is a novel model of personalized medicine in which the factor of a disease is predicted at an earlier stage and regulated by therapeutic interventions. To develop preemptive medicine for neuropsychiatric diseases, our department aims at discovering the molecular targets for neuropsychiatric diseases, such as stress-induced depression and tau lesion-induced Alzheimer's disease, using animal models and clinical research in order to develop diagnostic and therapeutic agents.

Members

Prof. Kuniaki Saito

Prof. Kuniaki Saito Director of Faculty of Medical Sciences and Professor of Department of Advanced Diagnostic System Development, Units on Research Promotion, Faculty of Medical Sciences, Fujita Health University

Objective diagnosis and assessment of psychiatric disorders are difficult because they are based on interviews and questionnaires. Our goal is to establish new biomarkers for psychiatric disorders from blood and other sources that can be used to assess the onset and severity of symptoms, and the efficacy of medications.

Prof. Toshitaka Nabeshima

Prof. Toshitaka Nabeshima Professor of Advanced Diagnostic System Research Laboratory, Fujita Health University, Graduate School of Health Sciences

The pathogenesis and etiology of neuropsychiatric disorders are complicated and diverse. We aim to overcome neuropsychiatric disorders by integrating clinical research analyzing the biomarkers of diseases with basic research using animal models and cell culture.

Dr. Akihiro Mouri

Dr. Akihiro Mouri Professor of Department of Regulatory Science, Interdepartmental Collaboration Unit, Faculties of Medical Technology and Radiological technology, Fujita Health University

Our goal is to develop novel therapeutic agents, phytochemicals, and diagnostic biomarkers. This will be achieved by analyzing pathological and pathogenic mechanisms of psychiatric disorders in mouse models that we develop based on epidemiological and genetic findings in patients.

Dr. Yasuko Yamamoto

Dr. Yasuko Yamamoto Associate Professor of Department of Advanced Diagnostic System Development, Units on Research Promotion, Faculty of Medical Sciences, Fujita Health University

In collaboration with the Resource Center for Health Science (RECHS), we aim to develop a diagnostic agent for neuropsychiatric disorders and to perform preemptive medicine by detecting changes before onset through analyzing annual serum samples and questionnaire data.

Dr. Hidetsugu Fujigaki

Dr. Hidetsugu Fujigaki Associate Professor of Department of Advanced Diagnostic System Development, Units on Research Promotion, Faculty of Medical Sciences, Fujita Health University

Kynurenine and other metabolites in the tryptophan metabolic pathway are related to the pathogenesis of neuropsychiatric disorders by acting as agonists or antagonists of neurotransmitter receptors. Our goal is to develop novel therapeutic agents by screening chemical compound libraries to find inhibitors of enzymes in tryptophan metabolism.

Dr. Kazuo Kunisawa

Dr. Kazuo Kunisawa Senior Assistant Professor of Department of Regulatory Science, Interdepartmental Collaboration Unit, Faculties of Medical Technology and Radiological technology, Fujita Health University

To elucidate the pathogenesis of neuropsychiatric disorders, we are analyzing 1) peripheral-central interactions through the composition of the intestinal microflora and function of peripheral immune cells, and 2) glial-neural interactions through glial cell-specific genetic interventions.

Main publications

  1. Kosuge A, Kunisawa K, Arai S, Sugawara Y, Shinohara K, Iida T, Wulaer B, Kawai T, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress. Brain Behav Immun. 2021 Aug;96:200-211. 
  2. Nakayama T, Okimura K, Shen J, Guh YJ, Tamai TK, Shimada A, Minou S, Okushi Y, Shimmura T, Furukawa Y, Kadofusa N, Sato A, Nishimura T, Tanaka M, Nakayama K, Shiina N, Yamamoto N, Loudon AS, Nishiwaki-Ohkawa T, Shinomiya A, Nabeshima T, Nakane Y, Yoshimura T. Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9594-9603.
  3. Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, Morikawa M, Nabeshima T, Ozaki N, Yamamoto Y, Saito K. Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. J Affect Disord. 2019 Aug 1;255:168-176. 
  4. Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science. 2013 Jan 18;339(6117):335-9. 
  5. Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya T, Miyamoto Y, Yamada K, Noda Y, Nabeshima T. MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. J Neurosci. 2012 Mar 28;32(13):4562-80. 

Information

Division of Neurochemistry(Disease Control and Prevention, Medical Sciences)

【Address】
#331#332, 3st building, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
【Contact】
E-mail:mouri(at)fujita-hu.ac.jp / Tel:+81-562-93-2520
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