The central nervous system (CNS) is modulated by peripheral factors, including blood metabolites and gut microbiota. Recent research has emphasized the concept of peripheral–central communication as a novel and promising framework for understanding brain function. Our division focuses on the peripheral immune system and how its dysregulation contributes to the pathophysiology of neuropsychiatric disorders with high unmet medical needs such as major depressive disorder, schizophrenia, and multiple sclerosis. Our research encompasses the full spectrum from mechanistic studies to the identification of biomarkers and therapeutic targets, with a strong emphasis on translational approaches. Based on our findings, we have secured multiple intellectual property rights and aim to leverage these discoveries for the development of innovative therapeutics and university-based startups—ultimately striving to deliver tangible benefits to patients.

Kazuo Kunisawa Associate Professor

Dr. Kunisawa investigates the molecular mechanisms of peripheral–central communication, with a focus on the functional analysis of peripheral immune cells and gut microbiota. His research centers on the discovery of therapeutic targets and biomarkers for neuropsychiatric disorders, and contributing to intellectual property development for the advancement of academic entrepreneurship.