International Center for Brain Science, FUJITA HEALTH UNIVERSITY

Division of Human Genetics and Genetic Research

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Projects

Using DNA samples collected from patients with psychiatric disorders, we will examine whether there is a difference in the frequency of genetic polymorphisms between patients with and without psychiatric disorders. Based on this analysis, we can narrow down the susceptibility regions associated with the psychiatric disorders. We can also detect the functional relevancy of susceptibility genes through collaboration with other departments at the International Center for Brain Science.

Members

Nakao Iwata

Nakao Iwata Professor

It is difficult to elucidate the pathogenesis of psychiatric disorders. However, to overcome this challenge, I have been working in the fields of neurobiochemistry, molecular biochemistry, and medical genetics. Medical genetics has made marked progress in the 21st century and has provided clues to solve complex problems in psychiatry. Now is the time for researchers in different fields to come together to make a great leap forward. I will continue to work hard to make this happen at the International Center for Brain Science.

Masashi Ikeda

Masashi Ikeda Visiting Professor

I am working towards detecting the susceptibility genes of psychiatric disorders. My main research area is statistical genetics for schizophrenia, bipolar disorder, and pharmacogenomic traits associated with drug response or adverse effects.

Satoshi Okouchi

Satoshi Okouchi Senior Assistant Professor

While practicing as a psychiatrist, I am also engaged in genetic research on psychiatric disorders. I am conducting pharmacogenomic studies on drug response and plasma concentrations of psychotropic drugs.

Takeo Saito

Takeo Saito Senior Assistant Professor

My research aims are to identify susceptibility genes of psychiatric disorders, mainly schizophrenia and bipolar disorder, using statistical genetics. I am also conducting pharmacogenomic studies on drug response and side effects of psychotropic drugs to generate data for precision medicine.

Kohei Ninomiya

Kohei Ninomiya Visiting Assistant Professor

While practicing as a psychiatrist, I am also engaged in genetic research on psychiatric disorders. I am conducting cost-effectiveness analysis to determine whether treatments using genetic testing are more cost-effective than conventional treatments.

Main publications

  1. Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A,
    Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T, Kikuchi M, Kanahara N,
    Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki
    M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R,
    Yoshikawa T, Kubo M, Iwata N. Genome-Wide Association Study Detected Novel
    Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases
    Genetic Effect. Schizophr Bull. 2019 Jun 18;45(4):824-834. doi:
    10.1093/schbul/sby140. PMID: 30285260; PMCID: PMC6581133.
  2. Ikeda M, Tanaka S, Saito T, Ozaki N, Kamatani Y, Iwata N. Re-evaluating
    classical body type theories: genetic correlation between psychiatric disorders
    and body mass index. Psychol Med. 2018 Jul;48(10):1745-1748. doi:
    10.1017/S0033291718000685. Epub 2018 Apr 13. PMID: 29651975; PMCID: PMC6088781.
  3. Ikeda M, Takahashi A, Kamatani Y, Okahisa Y, Kunugi H, Mori N, Sasaki T,
    Ohmori T, Okamoto Y, Kawasaki H, Shimodera S, Kato T, Yoneda H, Yoshimura R, Iyo
    M, Matsuda K, Akiyama M, Ashikawa K, Kashiwase K, Tokunaga K, Kondo K, Saito T,
    Shimasaki A, Kawase K, Kitajima T, Matsuo K, Itokawa M, Someya T, Inada T,
    Hashimoto R, Inoue T, Akiyama K, Tanii H, Arai H, Kanba S, Ozaki N, Kusumi I,
    Yoshikawa T, Kubo M, Iwata N. A genome-wide association study identifies two
    novel susceptibility loci and trans population polygenicity associated with
    bipolar disorder. Mol Psychiatry. 2018 Mar;23(3):639-647. doi:
    10.1038/mp.2016.259. Epub 2017 Jan 24. PMID: 28115744; PMCID: PMC5822448.
  4. Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K,
    Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M, Ohi K, Takeda M, Kamatani Y,
    Numata S, Ohmori T, Ueno S, Makinodan M, Nishihata Y, Kubota M, Kimura T,
    Kanahara N, Hashimoto N, Fujita K, Nemoto K, Fukao T, Suwa T, Noda T, Yada Y,
    Takaki M, Kida N, Otsuru T, Murakami M, Takahashi A, Kubo M, Hashimoto R, Iwata
    N. Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia
    in a Japanese Population. Biol Psychiatry. 2016 Oct 15;80(8):636-42. doi:
    10.1016/j.biopsych.2015.12.006. Epub 2016 Feb 11. PMID: 26876947.
  5. Ikeda M, Shimasaki A, Takahashi A, Kondo K, Saito T, Kawase K, Esaki K,
    Otsuka Y, Mano K, Kubo M, Iwata N. Genome-wide environment interaction between
    depressive state and stressful life events. J Clin Psychiatry. 2016
    Jan;77(1):e29-30. doi: 10.4088/JCP.15l10127. PMID: 26845276.

Information

Division of Human Genetics and Genetic Research（Psychiatry, School of Medicine）

Psychiatry, School of Medicine

【Address】
#517, 1st building, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan
【Contact】
E-mail：nakao(at)fujita-hu.ac.jp
※ Please replace “(at)” with “@”.

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